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- W2975588752 abstract "Abstract Osteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi‐injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme, hyaluronan synthase type 2 (HAS2), into synoviocytes from the temporomandibular joint (TMJ) and generate endogenous HA with high molecular weights. In a rat TMJ osteoarthritis inflammation model, this strategy promotes endogenous HA production and inhibits the synovial inflammation of OA for more than 3 weeks with one‐shot administration. Such nanotherapy also helps repairing the bone defects in a rat OA bone defect model." @default.
- W2975588752 created "2019-10-03" @default.
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- W2975588752 date "2019-09-24" @default.
- W2975588752 modified "2023-10-16" @default.
- W2975588752 title "Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2" @default.
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- W2975588752 doi "https://doi.org/10.1002/adma.201904535" @default.
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