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• W2975596929 abstract "Background The habit of smoking is a challenging situation, negatively affecting the osseointegration process. Nicotine reduces osteogenic activity and may contribute to impaired bone repair and increased risk of losing implants. The microstructure and surface characteristics of dental implants have a direct influence on bone response. Previous studies have shown that nanostructures applied to titanium surfaces may contribute to a higher bone to implant contact, therefore accelerating bone healing. Aim/Hypothesis This study aimed to analyze, in rats submitted to cigarette smoke inhalation, by Quantitative Real-Time PCR assessment, the biological response to a nano-hydroxyapatite implant surface, compared to double acid etched and machined surfaces, evaluating bone regeneration related gene expression. Materials and Methods Thirty-six rats were submitted to the inhalation of the smoke of 10 cigarettes, 3 times by day, during 60 days. On the thirtieth day of the experiment, mini implants (1.4 mm in diameter and 2.7 mm in length) with 3 types of surface (machined = MAC, double acid etched = DAE and with the addition of nano-hydroxyapatite = NHA + 12 implants of each type) were installed in the tibias of the animals. The rats were divided into three experimental groups (n = 12 each)- G1, MAC implants installed+ G2, DAE implants installed+ G3, NHA implants installed. The animals were euthanized 7 and 30 days (7d and 30d, 6 animals from each group) after implant placement, and bone biopsies around implants were collected and processed. Alkaline phosphatase (ALP), Osteopontin (OP), Runt related 2 transcription factor (RUNX 2), and Osteocalcin (OC) values were determined by quantitative real-time PCR evaluation. Inter-groups differences were assessed using One-way Analysis of Variance + Tukey tests (P < 0.05). Results For ALP, statistically significant differences were found between G1 30d (0.27 ± 0.05) versus G2 30d (0.70 ± 0.03) + between G1 30d versus G3 30d (1.18 ± 0.02) and between G2 30d versus G3 30d. For OP, the values were- G1 7d (1.00 ± 0.05), G2 7d (0.98 ± 0.04), G3 7d (1.77 ± 0.05), G1 30d (0.22 ± 0.05), G2 30d (0.76 ± 0.03), G3 30d (1.62 ± 0.05), with statistically significant differences for G1 7d x G3 7d, G2 7d x G3 7d, G1 30d x G2 30d, G1 30d x G3 30d and G2 30d x G3 30d. RUNX 2 analysis showed- G1 7d (1.00 ± 0.04), G2 7d (0.85 ± 0.03), G3 7d (1.08 ± 0.05), G1 30d (0.40 ± 0.03), G2 30d (0.70 ± 0.04), G3 30d (1.48 ± 0.04), with statistically significant differences between all groups both after 7 and 30 days. For OC evaluation, the values were- G1 7d (1.00 ± 0.19), G2 7d (0.59 ± 0.17), G3 7d (0.81 ± 0.22), G1 30d (0.81 ± 0.19), G2 30d (2.04 ± 0.15), G3 30d (2.91 ± 0.23), with statistically significant differences for G1 7d x G2 7d, G1 30d x G2 30d, G1 30d x G3 30d and G2 30d x G3 30d. Conclusion and Clinical Implications The nano-hydroxyapatite implant surface promoted an up-regulation in the osteogenesis gene expression when compared to machined or double acid etched surfaces, mainly in late (30 days after implant insertion) healing period, in rats submitted to cigarette smoke inhalation, as a model of deficient bone repair. These results suggest that this implant surface should be tested in humans, in trials evaluating challenging clinical situations." @default.
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• W2975596929 date "2019-09-01" @default.
• W2975596929 modified "2023-09-27" @default.
• W2975596929 title "Osteogenesis gene expression of nano‐HA covered implant in rats submitted to cigarette smoke inhalation" @default.
• W2975596929 doi "https://doi.org/10.1111/clr.64_13509" @default.
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