FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2975664495> ?p ?o ?g. }

• W2975664495 abstract "Abstract Sleep and sleep loss are affecting protein synthesis in the brain, but the contribution of translational control to wakefulness and sleep regulation remains poorly understood. Here, we studied the role of two suppressors of protein synthesis, the eukaryotic translation initiation factor 4E-binding proteins 1 and 2 (4E-BP1 and 4E-BP2), in sleep architecture and electroencephalographic (EEG) activity as well as in the EEG and molecular responses to acute sleep loss. The EEG of mice mutant for the genes encoding 4E-BP1 or 4E-BP2 (Eif4ebp1 and Eif4ebp2 knockout [KO] mice) was recorded under undisturbed conditions and following a 6-hour sleep deprivation (SD). The effect of SD on the expression of genes known to respond to SD was also measured in the prefrontal cortex of Eif4ebp1 and Eif4ebp2 KO mice. Eif4ebp1 KO mice differed from wild-type mice in parameters of wakefulness and sleep quantity and quality, and more subtly in the gene expression response to SD. For instance, Eif4ebp1 KO mice spent more time in slow-wave sleep (SWS) and showed altered baseline 24-h time courses of SWS delta (1–4 Hz) activity and sigma (10–13 Hz) activity. Eif4ebp2 KO mice differed from wild-type mice only for wakefulness and sleep quality, expressing changes in EEG spectral activity generally revealed during and after SD. These findings suggest different roles of effectors of translational control in the regulation of wakefulness and sleep and of synchronized cortical activity." @default.
• W2975664495 created "2019-10-03" @default.
• W2975664495 creator A5019902768 @default.
• W2975664495 creator A5019957951 @default.
• W2975664495 creator A5020937025 @default.
• W2975664495 creator A5034875914 @default.
• W2975664495 date "2019-09-25" @default.
• W2975664495 modified "2023-10-12" @default.
• W2975664495 title "Wakefulness/sleep architecture and electroencephalographic activity in mice lacking the translational repressor 4E-BP1 or 4E-BP2" @default.
• W2975664495 cites W1488974332 @default.
• W2975664495 cites W1495096570 @default.
• W2975664495 cites W1537142000 @default.
• W2975664495 cites W1973336419 @default.
• W2975664495 cites W1985093780 @default.
• W2975664495 cites W1988345639 @default.
• W2975664495 cites W1991142989 @default.
• W2975664495 cites W2016469892 @default.
• W2975664495 cites W2017764061 @default.
• W2975664495 cites W2026226894 @default.
• W2975664495 cites W2035016947 @default.
• W2975664495 cites W2035097065 @default.
• W2975664495 cites W2035149992 @default.
• W2975664495 cites W2037313242 @default.
• W2975664495 cites W2048862315 @default.
• W2975664495 cites W2052324806 @default.
• W2975664495 cites W2056994440 @default.
• W2975664495 cites W2059081424 @default.
• W2975664495 cites W2063210874 @default.
• W2975664495 cites W2071215075 @default.
• W2975664495 cites W2094234618 @default.
• W2975664495 cites W2108539898 @default.
• W2975664495 cites W2111975330 @default.
• W2975664495 cites W2124552207 @default.
• W2975664495 cites W2126268875 @default.
• W2975664495 cites W2128797181 @default.
• W2975664495 cites W2132968822 @default.
• W2975664495 cites W2135148159 @default.
• W2975664495 cites W2136921993 @default.
• W2975664495 cites W2137769667 @default.
• W2975664495 cites W2142099782 @default.
• W2975664495 cites W2157497892 @default.
• W2975664495 cites W2176786577 @default.
• W2975664495 cites W2206012323 @default.
• W2975664495 cites W2236052756 @default.
• W2975664495 cites W2255117473 @default.
• W2975664495 cites W2343190800 @default.
• W2975664495 cites W2411687688 @default.
• W2975664495 cites W2418497190 @default.
• W2975664495 cites W2522175331 @default.
• W2975664495 cites W2563950915 @default.
• W2975664495 cites W2576126713 @default.
• W2975664495 cites W2585275288 @default.
• W2975664495 cites W2620968806 @default.
• W2975664495 cites W2718983846 @default.
• W2975664495 cites W2891078453 @default.
• W2975664495 cites W2894711994 @default.
• W2975664495 doi "https://doi.org/10.1093/sleep/zsz210" @default.
• W2975664495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31553042" @default.
• W2975664495 hasPublicationYear "2019" @default.
• W2975664495 type Work @default.
• W2975664495 sameAs 2975664495 @default.
• W2975664495 citedByCount "3" @default.
• W2975664495 countsByYear W29756644952019 @default.
• W2975664495 countsByYear W29756644952022 @default.
• W2975664495 countsByYear W29756644952023 @default.
• W2975664495 crossrefType "journal-article" @default.
• W2975664495 hasAuthorship W2975664495A5019902768 @default.
• W2975664495 hasAuthorship W2975664495A5019957951 @default.
• W2975664495 hasAuthorship W2975664495A5020937025 @default.
• W2975664495 hasAuthorship W2975664495A5034875914 @default.
• W2975664495 hasBestOaLocation W29756644951 @default.
• W2975664495 hasConcept C110539466 @default.
• W2975664495 hasConcept C111919701 @default.
• W2975664495 hasConcept C121446783 @default.
• W2975664495 hasConcept C126322002 @default.
• W2975664495 hasConcept C134018914 @default.
• W2975664495 hasConcept C15744967 @default.
• W2975664495 hasConcept C169760540 @default.
• W2975664495 hasConcept C2775841894 @default.
• W2975664495 hasConcept C2778329153 @default.
• W2975664495 hasConcept C2779320081 @default.
• W2975664495 hasConcept C41008148 @default.
• W2975664495 hasConcept C522805319 @default.
• W2975664495 hasConcept C71924100 @default.
• W2975664495 hasConcept C86803240 @default.
• W2975664495 hasConceptScore W2975664495C110539466 @default.
• W2975664495 hasConceptScore W2975664495C111919701 @default.
• W2975664495 hasConceptScore W2975664495C121446783 @default.
• W2975664495 hasConceptScore W2975664495C126322002 @default.
• W2975664495 hasConceptScore W2975664495C134018914 @default.
• W2975664495 hasConceptScore W2975664495C15744967 @default.
• W2975664495 hasConceptScore W2975664495C169760540 @default.
• W2975664495 hasConceptScore W2975664495C2775841894 @default.
• W2975664495 hasConceptScore W2975664495C2778329153 @default.
• W2975664495 hasConceptScore W2975664495C2779320081 @default.
• W2975664495 hasConceptScore W2975664495C41008148 @default.
• W2975664495 hasConceptScore W2975664495C522805319 @default.
• W2975664495 hasConceptScore W2975664495C71924100 @default.
• W2975664495 hasConceptScore W2975664495C86803240 @default.
• W2975664495 hasFunder F4320323175 @default.

• next