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- W2975666700 abstract "Many patients suffering late-onset Alzheimer disease show a deficit in respiratory complex IV activity. The de novo pyrimidine biosynthesis pathway connects with the mitochondrial respiratory chain upstream from respiratory complex IV. We hypothesized that these patients would have decreased pyrimidine nucleotide levels. Then, different cell processes for which these compounds are essential, such as neuronal membrane generation and maintenance and synapses production, would be compromised. Using a cell model, we show that inhibiting oxidative phosphorylation function reduces neuronal differentiation. Linking these processes to pyrimidine nucleotides, uridine treatment recovers neuronal differentiation. To unmask the importance of these pathways in Alzheimer disease, we firstly confirm the existence of the de novo pyrimidine biosynthesis pathway in adult human brain. Then, we report altered mRNA levels for genes from both de novo pyrimidine biosynthesis and pyrimidine salvage pathways in brain from patients with Alzheimer disease. Thus, uridine supplementation might be used as a therapy for those Alzheimer disease patients with low respiratory complex IV activity." @default.
- W2975666700 created "2019-10-03" @default.
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- W2975666700 date "2019-09-27" @default.
- W2975666700 modified "2023-10-16" @default.
- W2975666700 title "Brain pyrimidine nucleotide synthesis and Alzheimer disease" @default.
- W2975666700 cites W150728573 @default.
- W2975666700 cites W1532989877 @default.
- W2975666700 cites W1552916016 @default.
- W2975666700 cites W1565810327 @default.
- W2975666700 cites W1604682243 @default.
- W2975666700 cites W1698967089 @default.
- W2975666700 cites W1829374838 @default.
- W2975666700 cites W1866144427 @default.
- W2975666700 cites W1880092164 @default.
- W2975666700 cites W1933771638 @default.
- W2975666700 cites W1959882307 @default.
- W2975666700 cites W1964717435 @default.
- W2975666700 cites W1968188575 @default.
- W2975666700 cites W1983167253 @default.
- W2975666700 cites W1983187284 @default.
- W2975666700 cites W1983895342 @default.
- W2975666700 cites W1984420597 @default.
- W2975666700 cites W1985180392 @default.
- W2975666700 cites W1985667235 @default.
- W2975666700 cites W1987301978 @default.
- W2975666700 cites W1992976919 @default.
- W2975666700 cites W1993023011 @default.
- W2975666700 cites W1996084069 @default.
- W2975666700 cites W2000853431 @default.
- W2975666700 cites W2004384294 @default.
- W2975666700 cites W2006909664 @default.
- W2975666700 cites W2007136766 @default.
- W2975666700 cites W2007466714 @default.
- W2975666700 cites W2009110449 @default.
- W2975666700 cites W2011156519 @default.
- W2975666700 cites W2013915220 @default.
- W2975666700 cites W2014357210 @default.
- W2975666700 cites W2014536853 @default.
- W2975666700 cites W2015079614 @default.
- W2975666700 cites W2015097735 @default.
- W2975666700 cites W2019622095 @default.
- W2975666700 cites W2019899774 @default.
- W2975666700 cites W2021134013 @default.
- W2975666700 cites W2028495589 @default.
- W2975666700 cites W2029053966 @default.
- W2975666700 cites W2029548280 @default.
- W2975666700 cites W2031224352 @default.
- W2975666700 cites W2033548521 @default.
- W2975666700 cites W2037181602 @default.
- W2975666700 cites W2038034523 @default.
- W2975666700 cites W2040258716 @default.
- W2975666700 cites W2040628961 @default.
- W2975666700 cites W2040892857 @default.
- W2975666700 cites W2041625394 @default.
- W2975666700 cites W2045470134 @default.
- W2975666700 cites W2052742260 @default.
- W2975666700 cites W2053745263 @default.
- W2975666700 cites W2053797563 @default.
- W2975666700 cites W2054376484 @default.
- W2975666700 cites W2056895253 @default.
- W2975666700 cites W2062715442 @default.
- W2975666700 cites W2063602420 @default.
- W2975666700 cites W2065478731 @default.
- W2975666700 cites W2067859344 @default.
- W2975666700 cites W2069821327 @default.
- W2975666700 cites W2074390534 @default.
- W2975666700 cites W2074509666 @default.
- W2975666700 cites W2075497929 @default.
- W2975666700 cites W2076241970 @default.
- W2975666700 cites W2079353144 @default.
- W2975666700 cites W2080184198 @default.
- W2975666700 cites W2082429191 @default.
- W2975666700 cites W2090211150 @default.
- W2975666700 cites W2096258784 @default.
- W2975666700 cites W2102117809 @default.
- W2975666700 cites W2103440561 @default.
- W2975666700 cites W2104509418 @default.
- W2975666700 cites W2104598975 @default.
- W2975666700 cites W2124321678 @default.
- W2975666700 cites W2137769340 @default.
- W2975666700 cites W2141091417 @default.
- W2975666700 cites W2141282621 @default.
- W2975666700 cites W2145775543 @default.
- W2975666700 cites W2154417145 @default.
- W2975666700 cites W2157628131 @default.
- W2975666700 cites W2160699404 @default.