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• W2975763109 abstract "To compare pregnancy rate, clinical pregnancy rate and implantation rate of frozen-thawed embryo transfer (FET) cycles of donors and recipients. A prospective randomized controlled trial. Between November 2017 to December 2018, we select 49 oocyte donors that would be submitted to ovarian stimulation in a shared egg donor cycle. All donors were younger than 35 years-old. Computerized randomization was conducted to assign participants into two treatment groups: hMG + dydrogesterone 10 mg 12/12h (DYG) (24 patients) or hMG + ganirelix acetate (25 patients). Oocyte maturation was triggered by administration of triptorelin. The collected mature eggs of each donor were divided half-way with a recipient and fertilized. All viable blastocysts were cryopreserved for later transfer. Only the first FET cycle was included in our study. We compared the number of oocytes and mature oocytes retrieved in the two groups. Fertilization rate (FR), number of blastocysts, pregnancy rate (PR), clinical pregnancy rate (CPR) and implantation rate (IR) of donors were compared separately from recipients . The mean age of donors was 29.0 (DYG group) and 28.6 (ganirelix group). No cycle was cancelled because of premature LH surge. The mean number of oocytes and methaphase II (MII) were not different: 26.75 and 19.83 with DYG and 28.3 and 21.5 with ganirelix. For donors using DYG, FR was 74.1% and the mean number of blastocyts was 3.42. In ganirelix group, FR was 79.55% and 3.36 blastocysts were formed (not significant). There was also no difference in PR, CPR and IR: 79.2%, 62.5% and 63.4% for DYG and 76%, 58.3% and 55.8% for ganirelix. Analyzing recipients that received oocytes from DYG group donors, the FR was 84.3%, the mean number of blastocyts was 3.61, PR was 63.6%, CPR was 59.1% and IR, 46.5%. For recipients using oocytes from ganirelix group donors, FR was 85.9%, mean number of blastocysts was 3.6, PR was 66.7%, CPR was 54% and IR, 17%. There was no statistical significant difference between the groups for any outcomes of donors or recipients. Ovarian stimulation using DYG for prevention of LH surge yields similar outcomes compared to ganirelix in shared oocyte donor cycle with subsequent FET in donors and recipients." @default.
• W2975763109 created "2019-10-03" @default.
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• W2975763109 date "2019-09-01" @default.
• W2975763109 modified "2023-10-18" @default.
• W2975763109 title "Dydrogesterone for prevent LH surge yields similar outcomes to ganirelix in a shared oocyte donor cycle with subsequent frozen-thawed embryo transfer: comparison of donors and recipients" @default.
• W2975763109 doi "https://doi.org/10.1016/j.fertnstert.2019.07.628" @default.
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