Matches in SemOpenAlex for { <https://semopenalex.org/work/W2975790812> ?p ?o ?g. }
- W2975790812 abstract "Summary Tumor heterogeneity and cisplatin resistance are a major cause of tumor relapse and poor survival. Here we show that in lung adenocarcinoma (LUAD), paxillin (PXN) and integrin beta 4 (ITGB4) are associated with tumor progression, and cisplatin resistance. Silencing PXN and ITGB4 render cisplatin tolerant cells sensitive, and immunologically neutralizing ITGB4 improves sensitivity. The N-terminal half of PXN is intrinsically disordered and interacts with ITGB4 to regulate expression of USP1 and VDAC1 which are required for maintaining genomic stability and mitochondrial function in LUAD. By virtual screening an FDA-approved compound library, we identified compounds that interact with PXN in silico and attenuate cisplatin resistance in LUAD cells. RNAseq analysis identified a double negative feedback loop between ITGB4 and microRNA miR-1-3p, suggesting that bistability could lead to stochastic switching between cisplatin-sensitive and resistant states in these cells. The data highlight an alternate, non-genetic, mechanism underlying chemoresistance in lung cancer." @default.
- W2975790812 created "2019-10-03" @default.
- W2975790812 creator A5006254248 @default.
- W2975790812 creator A5006711911 @default.
- W2975790812 creator A5007937560 @default.
- W2975790812 creator A5009470333 @default.
- W2975790812 creator A5012380163 @default.
- W2975790812 creator A5017980532 @default.
- W2975790812 creator A5018001380 @default.
- W2975790812 creator A5019101391 @default.
- W2975790812 creator A5020914791 @default.
- W2975790812 creator A5023989141 @default.
- W2975790812 creator A5025544408 @default.
- W2975790812 creator A5027357642 @default.
- W2975790812 creator A5028021994 @default.
- W2975790812 creator A5028715423 @default.
- W2975790812 creator A5040658425 @default.
- W2975790812 creator A5051698935 @default.
- W2975790812 creator A5051970161 @default.
- W2975790812 creator A5054370453 @default.
- W2975790812 creator A5059052987 @default.
- W2975790812 creator A5063896178 @default.
- W2975790812 creator A5064759824 @default.
- W2975790812 creator A5068232426 @default.
- W2975790812 creator A5083772852 @default.
- W2975790812 creator A5085256777 @default.
- W2975790812 date "2019-09-25" @default.
- W2975790812 modified "2023-10-16" @default.
- W2975790812 title "A Non-genetic Mechanism for Chemoresistance in Lung Cancer: The Role of Integrin β4/Paxillin Axis" @default.
- W2975790812 cites W1488252042 @default.
- W2975790812 cites W1525629072 @default.
- W2975790812 cites W1859579038 @default.
- W2975790812 cites W1906177977 @default.
- W2975790812 cites W1950118853 @default.
- W2975790812 cites W1967402966 @default.
- W2975790812 cites W1969867377 @default.
- W2975790812 cites W1970708036 @default.
- W2975790812 cites W1980830316 @default.
- W2975790812 cites W1994032485 @default.
- W2975790812 cites W1995213405 @default.
- W2975790812 cites W2001403509 @default.
- W2975790812 cites W2008620264 @default.
- W2975790812 cites W2011848873 @default.
- W2975790812 cites W2015115860 @default.
- W2975790812 cites W2015802360 @default.
- W2975790812 cites W2018728469 @default.
- W2975790812 cites W2019156893 @default.
- W2975790812 cites W2022881840 @default.
- W2975790812 cites W2026313208 @default.
- W2975790812 cites W2029693715 @default.
- W2975790812 cites W2036808607 @default.
- W2975790812 cites W2042028177 @default.
- W2975790812 cites W2066137841 @default.
- W2975790812 cites W2080815560 @default.
- W2975790812 cites W2107552761 @default.
- W2975790812 cites W2113739044 @default.
- W2975790812 cites W2125505694 @default.
- W2975790812 cites W2125792957 @default.
- W2975790812 cites W2126099124 @default.
- W2975790812 cites W2126410372 @default.
- W2975790812 cites W2127791872 @default.
- W2975790812 cites W2134558237 @default.
- W2975790812 cites W2137088684 @default.
- W2975790812 cites W2137129298 @default.
- W2975790812 cites W2141037581 @default.
- W2975790812 cites W2150322923 @default.
- W2975790812 cites W2156752428 @default.
- W2975790812 cites W2157346939 @default.
- W2975790812 cites W2157923000 @default.
- W2975790812 cites W2158037819 @default.
- W2975790812 cites W2159515687 @default.
- W2975790812 cites W2160803964 @default.
- W2975790812 cites W2162723598 @default.
- W2975790812 cites W2171642372 @default.
- W2975790812 cites W2259656061 @default.
- W2975790812 cites W2265452059 @default.
- W2975790812 cites W2301216929 @default.
- W2975790812 cites W2301705357 @default.
- W2975790812 cites W2301705957 @default.
- W2975790812 cites W2335098315 @default.
- W2975790812 cites W2346906535 @default.
- W2975790812 cites W2398660216 @default.
- W2975790812 cites W2404834517 @default.
- W2975790812 cites W2567785701 @default.
- W2975790812 cites W2600259521 @default.
- W2975790812 cites W2606595919 @default.
- W2975790812 cites W2616721380 @default.
- W2975790812 cites W2735792968 @default.
- W2975790812 cites W2738581806 @default.
- W2975790812 cites W2749616691 @default.
- W2975790812 cites W2766206099 @default.
- W2975790812 cites W2780927228 @default.
- W2975790812 cites W2784371446 @default.
- W2975790812 cites W2797375388 @default.
- W2975790812 cites W2801791765 @default.
- W2975790812 cites W2801896245 @default.
- W2975790812 cites W2889646458 @default.
- W2975790812 cites W2898458903 @default.
- W2975790812 cites W2906671565 @default.
- W2975790812 cites W2940857775 @default.