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• W2975952610 abstract "We have recently reported about shorter proteolytic peptides termed Catalytide as general name. JAL-TA9 (YKGSGFRMI), a fragment peptide derived from Box A region of Tob1 protein, is the first Catalytide and cleaves Aβ42 and its fragment peptides.Herein, we demonstrate the enzymatic properties of ANA-TA9 corresponding region to JAL-TA9 in ANA/BTG3 protein. ANA-TA9 showed the auto-proteolytic activity and cleaved 3 kinds of synthetic fragment peptides derived from Aβ42, especially on the central region of Aβ42 with a serine protease like activity. Interestingly, 2 kinds of components, ANA-SA5 (SKGQA) and ANA-YA4 (YRMI), also showed similar proteolytic activity. These results indicate that ANA-TA9 is composed of two different Catalytides." @default.
• W2975952610 created "2019-10-03" @default.
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• W2975952610 date "2019-09-01" @default.
• W2975952610 modified "2023-09-30" @default.
• W2975952610 title "Catalytides derived from the Box A region in the ANA/BTG3 protein cleave amyloid-β fragment peptide" @default.
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• W2975952610 doi "https://doi.org/10.1016/j.heliyon.2019.e02454" @default.
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