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- W2975955690 abstract "The small leucine-rich proteoglycan (SLRP) family consists of 18 members categorized into five distinct classes, the traditional classes I–III and the non-canonical classes IV–V. Unlike the other class I SLRPs (decorin and biglycan), asporin contains a unique and conserved stretch of aspartate (D) residues in its N terminus, and germline polymorphisms in the D-repeat-length are associated with osteoarthritis and prostate cancer progression. Since the first discovery of asporin in 2001, previous studies have focused mainly on its roles in bone and joint diseases, including osteoarthritis, intervertebral disc degeneration, and periodontal ligament mineralization. Recently, asporin gene expression was also reported to be dysregulated in tumor tissues of different types of cancer, and to act as an oncogene in pancreatic, colorectal, gastric, and prostate cancers, and some types of breast cancer, although it is also reported to function as a tumor suppressor gene in triple-negative breast cancer. Furthermore, asporin is also positively or negatively correlated with tumor proliferation, migration, invasion, and patient prognosis through its regulation of different signaling pathways, including the TGF-beta, EGFR, and CD44 pathways. In this review, we seek to elucidate the signaling pathways and functions regulated by asporin in different types of cancer and to highlight some important issues that require investigation in future research." @default.
- W2975955690 created "2019-10-03" @default.
- W2975955690 creator A5024725065 @default.
- W2975955690 creator A5038934949 @default.
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- W2975955690 date "2019-09-24" @default.
- W2975955690 modified "2023-10-02" @default.
- W2975955690 title "Multifaceted Roles of Asporin in Cancer: Current Understanding" @default.
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- W2975955690 doi "https://doi.org/10.3389/fonc.2019.00948" @default.
- W2975955690 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6771297" @default.
- W2975955690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31608236" @default.
- W2975955690 hasPublicationYear "2019" @default.
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