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- W2975972480 endingPage "100964" @default.
- W2975972480 startingPage "100964" @default.
- W2975972480 abstract "Specific hallmarks are thought to underlie the ageing process and age-related functional decline. In this viewpoint, we put forward the hypothesis that disturbances in the process of tissue maintenance are an important common denominator that may lie in between specific hallmarks of ageing (i.e. damage and responses to damage) and their ultimate (patho)physiological consequences (i.e. functional decline and age-related disease). As a first step towards verifying or falsifying this hypothesis, it will be important to measure biomarkers of tissue maintenance in future studies in different study populations. The main aim of the current paper is to discuss potential biomarkers of tissue maintenance that could be used in such future studies. Among the many tissues that could have been chosen to explore our hypothesis, to keep the paper manageable, we chose to focus on a selected number of tissues, namely bone, cartilage, muscle, and the brain, which are important for mobility and cognition and affected in several common age-related diseases, including osteoporosis, osteoarthritis, sarcopenia, and neurodegenerative diseases. Furthermore, we discuss the advantages and limitations of potential biomarkers for use in (pre)clinical studies. The proposed biomarkers should be validated in future research, for example by measuring these in humans with different rates of ageing." @default.
- W2975972480 created "2019-10-03" @default.
- W2975972480 creator A5004038774 @default.
- W2975972480 creator A5035860380 @default.
- W2975972480 creator A5049945628 @default.
- W2975972480 date "2019-12-01" @default.
- W2975972480 modified "2023-09-30" @default.
- W2975972480 title "Viewpoint on the role of tissue maintenance in ageing: focus on biomarkers of bone, cartilage, muscle, and brain tissue maintenance" @default.
- W2975972480 cites W1504661786 @default.
- W2975972480 cites W1524549603 @default.
- W2975972480 cites W1542740939 @default.
- W2975972480 cites W1557541313 @default.
- W2975972480 cites W1597412170 @default.
- W2975972480 cites W1658682427 @default.
- W2975972480 cites W1783814439 @default.
- W2975972480 cites W1784988360 @default.
- W2975972480 cites W1821132190 @default.
- W2975972480 cites W1892299904 @default.
- W2975972480 cites W1900158970 @default.
- W2975972480 cites W1929193411 @default.
- W2975972480 cites W1963916234 @default.
- W2975972480 cites W1965927192 @default.
- W2975972480 cites W1967057044 @default.
- W2975972480 cites W1967644150 @default.
- W2975972480 cites W1970823846 @default.
- W2975972480 cites W1971208141 @default.
- W2975972480 cites W1971262381 @default.
- W2975972480 cites W1975766549 @default.
- W2975972480 cites W1977737799 @default.
- W2975972480 cites W1978927200 @default.
- W2975972480 cites W1980499453 @default.
- W2975972480 cites W1982481909 @default.
- W2975972480 cites W1983955843 @default.
- W2975972480 cites W1985058290 @default.
- W2975972480 cites W1986550196 @default.
- W2975972480 cites W1986674928 @default.
- W2975972480 cites W1989070021 @default.
- W2975972480 cites W1992695399 @default.
- W2975972480 cites W1993571512 @default.
- W2975972480 cites W1996080203 @default.
- W2975972480 cites W2005779589 @default.
- W2975972480 cites W2006325146 @default.
- W2975972480 cites W2006858320 @default.
- W2975972480 cites W2009429260 @default.
- W2975972480 cites W2014566205 @default.
- W2975972480 cites W2014732422 @default.
- W2975972480 cites W2015573921 @default.
- W2975972480 cites W2015997553 @default.
- W2975972480 cites W2019214663 @default.
- W2975972480 cites W2020212606 @default.
- W2975972480 cites W2020498098 @default.
- W2975972480 cites W2021832011 @default.
- W2975972480 cites W2022510390 @default.
- W2975972480 cites W2023156173 @default.
- W2975972480 cites W2026123588 @default.
- W2975972480 cites W2026574460 @default.
- W2975972480 cites W2029935277 @default.
- W2975972480 cites W2030453203 @default.
- W2975972480 cites W2033713750 @default.
- W2975972480 cites W2034286717 @default.
- W2975972480 cites W2037421670 @default.
- W2975972480 cites W2043326667 @default.
- W2975972480 cites W2045631728 @default.
- W2975972480 cites W2049842278 @default.
- W2975972480 cites W2051273684 @default.
- W2975972480 cites W2052132290 @default.
- W2975972480 cites W2052534203 @default.
- W2975972480 cites W2052774376 @default.
- W2975972480 cites W2053352519 @default.
- W2975972480 cites W2054007740 @default.
- W2975972480 cites W2054221638 @default.
- W2975972480 cites W2055776141 @default.
- W2975972480 cites W2056950172 @default.
- W2975972480 cites W2057896169 @default.
- W2975972480 cites W2058647265 @default.
- W2975972480 cites W2067668638 @default.
- W2975972480 cites W2068298721 @default.
- W2975972480 cites W2069353802 @default.
- W2975972480 cites W2072399660 @default.
- W2975972480 cites W2072473425 @default.
- W2975972480 cites W2074286280 @default.
- W2975972480 cites W2074427084 @default.
- W2975972480 cites W2074556387 @default.
- W2975972480 cites W2075193321 @default.
- W2975972480 cites W2075575934 @default.
- W2975972480 cites W2082402714 @default.
- W2975972480 cites W2082520269 @default.
- W2975972480 cites W2083279848 @default.
- W2975972480 cites W2085525271 @default.
- W2975972480 cites W2087029475 @default.
- W2975972480 cites W2087560312 @default.
- W2975972480 cites W2089357045 @default.
- W2975972480 cites W2090433287 @default.
- W2975972480 cites W2091244598 @default.
- W2975972480 cites W2091403268 @default.
- W2975972480 cites W2091418075 @default.
- W2975972480 cites W2095915465 @default.
- W2975972480 cites W2096410114 @default.