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• W2975996880 abstract "Ageing is the result of changes in biochemical and biophysical processes at the cellular level that lead to progressive organ decline. Here we focus on the biophysical changes that impair cellular function of human dermal fibroblasts using donors of increasing age. We find that cell motility is impaired in cells from older donors, which is associated with increased Young’s modulus, viscosity, and adhesion. Cellular morphology also displays parallel increases in spread area and cytoskeletal assembly, with a threefold increase in vimentin filaments alongside a decrease in its remodelling rate. Treatments with withaferin A or acrylamide show that cell motility can be modulated by regulating vimentin assembly. Crucially, decreasing vimentin amount in cells from older individuals to levels displayed by the neonatal donor rescues their motility. Our results suggest that increased vimentin assembly may underlay the aberrant biophysical properties progressively observed at the cellular level in the course of human ageing and propose vimentin as a potential therapeutic target for ageing-related diseases." @default.
• W2975996880 created "2019-10-03" @default.
• W2975996880 creator A5012789494 @default.
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• W2975996880 date "2019-09-27" @default.
• W2975996880 modified "2023-10-18" @default.
• W2975996880 title "Vimentin Plays a Crucial Role in Fibroblast Ageing by Regulating Biophysical Properties and Cell Migration" @default.
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• W2975996880 doi "https://doi.org/10.3390/cells8101164" @default.
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• W2975996880 hasPublicationYear "2019" @default.
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