Matches in SemOpenAlex for { <https://semopenalex.org/work/W2975999623> ?p ?o ?g. }
- W2975999623 endingPage "494" @default.
- W2975999623 startingPage "485" @default.
- W2975999623 abstract "Abstract Ethyl2‐acetylamino‐7‐hydroxy‐4‐pyridin‐3‐yl‐4H‐chromene‐3‐carboxylate (HFI‐419), the benzopyran‐based inhibitor of insulin‐regulated aminopeptidase (IRAP), has previously been shown to improve spatial working and recognition memory in rodents. However, the mechanism of its cognitive‐enhancing effect remains unknown. There is a close correlation between dendritic spine density and learning in vivo and several studies suggest that increases in neuronal glucose uptake and/or alterations to the activity of matrix metalloproteinases (MMPs) may improve memory and increase dendritic spine density. We aimed to identify the potential mechanism by which HFI‐419 enhances memory by utilizing rat primary cultures of hippocampal cells. Alterations to dendritic spine density were assessed in the presence of varying concentrations of HFI‐419 at different stages of hippocampal cell development. In addition, glucose uptake and changes to spine density were assessed in the presence of indinavir, an inhibitor of the glucose transporter 4 (GLUT 4 ), or the matrix metalloprotease inhibitor CAS 204140‐01‐2. We confirmed that inhibition of IRAP activity with HFI‐419 enhanced spatial working memory in rats, and determined that this enhancement may be driven by GLUT 4 ‐mediated changes to dendritic spine density. We observed that IRAP inhibition increased dendritic spine density prior to peak dendritic growth in hippocampal neurons, and that spine formation was inhibited when GLUT 4 ‐mediated glucose uptake was blocked. In addition, during the peak phase of dendritic spine growth, the effect of IRAP inhibition on enhancement of dendritic spine density resulted specifically in an increase in the proportion of mushroom/stubby‐like spines, a morphology associated with memory and learning. Moreover, these spines were deemed to be functional based on their expression of the pre‐synaptic markers vesicular glutamate transporter 1 and synapsin. Overall, or findings suggest that IRAP inhibitors may facilitate memory by increasing hippocampal dendritic spine density via a GLUT 4 ‐mediated mechanism. image Cover Image for this issue: doi: 10.1111/jnc.14745 ." @default.
- W2975999623 created "2019-10-03" @default.
- W2975999623 creator A5018924999 @default.
- W2975999623 creator A5024050557 @default.
- W2975999623 creator A5032994975 @default.
- W2975999623 creator A5038720064 @default.
- W2975999623 creator A5069977977 @default.
- W2975999623 creator A5073167752 @default.
- W2975999623 creator A5091135752 @default.
- W2975999623 date "2019-10-16" @default.
- W2975999623 modified "2023-09-27" @default.
- W2975999623 title "Insulin‐regulated aminopeptidase inhibitor‐mediated increases in dendritic spine density are facilitated by glucose uptake" @default.
- W2975999623 cites W1512110535 @default.
- W2975999623 cites W1564626456 @default.
- W2975999623 cites W1979040830 @default.
- W2975999623 cites W1980452424 @default.
- W2975999623 cites W1988994847 @default.
- W2975999623 cites W2003432290 @default.
- W2975999623 cites W2005585462 @default.
- W2975999623 cites W2010627562 @default.
- W2975999623 cites W2012332990 @default.
- W2975999623 cites W2013492967 @default.
- W2975999623 cites W2015361812 @default.
- W2975999623 cites W2015472050 @default.
- W2975999623 cites W2019523818 @default.
- W2975999623 cites W2021036812 @default.
- W2975999623 cites W2025605916 @default.
- W2975999623 cites W2027424219 @default.
- W2975999623 cites W2032310176 @default.
- W2975999623 cites W2039969351 @default.
- W2975999623 cites W2044409604 @default.
- W2975999623 cites W2049904238 @default.
- W2975999623 cites W2058255055 @default.
- W2975999623 cites W2058990911 @default.
- W2975999623 cites W2061482726 @default.
- W2975999623 cites W2062635423 @default.
- W2975999623 cites W2068848753 @default.
- W2975999623 cites W2069987788 @default.
- W2975999623 cites W2073341848 @default.
- W2975999623 cites W2079709354 @default.
- W2975999623 cites W2088240537 @default.
- W2975999623 cites W2095128938 @default.
- W2975999623 cites W2118037728 @default.
- W2975999623 cites W2138910339 @default.
- W2975999623 cites W2140202716 @default.
- W2975999623 cites W2143549199 @default.
- W2975999623 cites W2254827003 @default.
- W2975999623 cites W2321486909 @default.
- W2975999623 cites W2537313620 @default.
- W2975999623 cites W2591336757 @default.
- W2975999623 cites W4248221854 @default.
- W2975999623 doi "https://doi.org/10.1111/jnc.14880" @default.
- W2975999623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31556456" @default.
- W2975999623 hasPublicationYear "2019" @default.
- W2975999623 type Work @default.
- W2975999623 sameAs 2975999623 @default.
- W2975999623 citedByCount "10" @default.
- W2975999623 countsByYear W29759996232020 @default.
- W2975999623 countsByYear W29759996232021 @default.
- W2975999623 countsByYear W29759996232022 @default.
- W2975999623 countsByYear W29759996232023 @default.
- W2975999623 crossrefType "journal-article" @default.
- W2975999623 hasAuthorship W2975999623A5018924999 @default.
- W2975999623 hasAuthorship W2975999623A5024050557 @default.
- W2975999623 hasAuthorship W2975999623A5032994975 @default.
- W2975999623 hasAuthorship W2975999623A5038720064 @default.
- W2975999623 hasAuthorship W2975999623A5069977977 @default.
- W2975999623 hasAuthorship W2975999623A5073167752 @default.
- W2975999623 hasAuthorship W2975999623A5091135752 @default.
- W2975999623 hasBestOaLocation W29759996231 @default.
- W2975999623 hasConcept C109523444 @default.
- W2975999623 hasConcept C126322002 @default.
- W2975999623 hasConcept C134018914 @default.
- W2975999623 hasConcept C148762608 @default.
- W2975999623 hasConcept C174884520 @default.
- W2975999623 hasConcept C185592680 @default.
- W2975999623 hasConcept C205383261 @default.
- W2975999623 hasConcept C2777866211 @default.
- W2975999623 hasConcept C2779306644 @default.
- W2975999623 hasConcept C55493867 @default.
- W2975999623 hasConcept C71924100 @default.
- W2975999623 hasConcept C86803240 @default.
- W2975999623 hasConcept C95444343 @default.
- W2975999623 hasConceptScore W2975999623C109523444 @default.
- W2975999623 hasConceptScore W2975999623C126322002 @default.
- W2975999623 hasConceptScore W2975999623C134018914 @default.
- W2975999623 hasConceptScore W2975999623C148762608 @default.
- W2975999623 hasConceptScore W2975999623C174884520 @default.
- W2975999623 hasConceptScore W2975999623C185592680 @default.
- W2975999623 hasConceptScore W2975999623C205383261 @default.
- W2975999623 hasConceptScore W2975999623C2777866211 @default.
- W2975999623 hasConceptScore W2975999623C2779306644 @default.
- W2975999623 hasConceptScore W2975999623C55493867 @default.
- W2975999623 hasConceptScore W2975999623C71924100 @default.
- W2975999623 hasConceptScore W2975999623C86803240 @default.
- W2975999623 hasConceptScore W2975999623C95444343 @default.
- W2975999623 hasFunder F4320322168 @default.
- W2975999623 hasFunder F4320322581 @default.