FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2976078337> ?p ?o ?g. }

• W2976078337 endingPage "688" @default.
• W2976078337 startingPage "685" @default.
• W2976078337 abstract "Atorvastatin combined with amlodipine (ALDP) can efficiently treat the hypertension with coronary heart disease. However, the drug-drug interaction between atorvastatin and ALDP are still unknown.This study investigates the effects of atorvastatin on the pharmacokinetics of ALDP in rats and clarifies its main mechanism.The pharmacokinetic profiles of oral administration of ALDP (1 mg/kg) in Sprague-Dawley rats, with or without pretreatment of atorvastatin (1.5 mg/kg/d for 7 d) were investigated. The effects of atorvastatin on the metabolism of ALDP were also investigated using rat liver microsomes.The results showed that atorvastatin could significantly increase the peak plasma concentration (from 18.28 ± 2.65 to 24.13 ± 1.96 ng/mL) and decrease the oral clearance (from 4.57 ± 1.15 to 1.79 ± 0.28 L/h/kg) of ALDP. In the rat liver microsome systems, the intrinsic clearance rate of ALDP was decreased by the pretreatment with atorvastatin (39.26 ± 2.1 vs. 33.24 ± 3.3 μL/min/mg protein).Those results indicated that atorvastatin could significantly affect the pharmacokinetic of ALDP, via inhibiting the metabolism of ALDP in rats." @default.
• W2976078337 created "2019-10-03" @default.
• W2976078337 creator A5009487022 @default.
• W2976078337 creator A5023034801 @default.
• W2976078337 creator A5030686595 @default.
• W2976078337 creator A5066334922 @default.
• W2976078337 creator A5080641302 @default.
• W2976078337 creator A5082102743 @default.
• W2976078337 date "2019-10-09" @default.
• W2976078337 modified "2023-10-17" @default.
• W2976078337 title "Effects of atorvastatin on pharmacokinetics of amlodipine in rats and its potential mechanism" @default.
• W2976078337 cites W1244992994 @default.
• W2976078337 cites W1510298788 @default.
• W2976078337 cites W1974702385 @default.
• W2976078337 cites W1978502180 @default.
• W2976078337 cites W1992065855 @default.
• W2976078337 cites W1996504894 @default.
• W2976078337 cites W2096983446 @default.
• W2976078337 cites W2117325608 @default.
• W2976078337 cites W2132220387 @default.
• W2976078337 cites W2133614345 @default.
• W2976078337 cites W2148658259 @default.
• W2976078337 cites W2158630963 @default.
• W2976078337 cites W2170676717 @default.
• W2976078337 cites W2191489996 @default.
• W2976078337 cites W2344917874 @default.
• W2976078337 cites W2345002959 @default.
• W2976078337 cites W2461042960 @default.
• W2976078337 cites W2474172802 @default.
• W2976078337 cites W2584851888 @default.
• W2976078337 cites W2623463380 @default.
• W2976078337 cites W2771508544 @default.
• W2976078337 cites W2792095368 @default.
• W2976078337 cites W2792371826 @default.
• W2976078337 cites W2891440387 @default.
• W2976078337 cites W2944066923 @default.
• W2976078337 doi "https://doi.org/10.1080/00498254.2019.1673918" @default.
• W2976078337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31556335" @default.
• W2976078337 hasPublicationYear "2019" @default.
• W2976078337 type Work @default.
• W2976078337 sameAs 2976078337 @default.
• W2976078337 citedByCount "3" @default.
• W2976078337 countsByYear W29760783372020 @default.
• W2976078337 countsByYear W29760783372021 @default.
• W2976078337 countsByYear W29760783372023 @default.
• W2976078337 crossrefType "journal-article" @default.
• W2976078337 hasAuthorship W2976078337A5009487022 @default.
• W2976078337 hasAuthorship W2976078337A5023034801 @default.
• W2976078337 hasAuthorship W2976078337A5030686595 @default.
• W2976078337 hasAuthorship W2976078337A5066334922 @default.
• W2976078337 hasAuthorship W2976078337A5080641302 @default.
• W2976078337 hasAuthorship W2976078337A5082102743 @default.
• W2976078337 hasConcept C112705442 @default.
• W2976078337 hasConcept C126322002 @default.
• W2976078337 hasConcept C181199279 @default.
• W2976078337 hasConcept C185592680 @default.
• W2976078337 hasConcept C2777056448 @default.
• W2976078337 hasConcept C2777482532 @default.
• W2976078337 hasConcept C2779646130 @default.
• W2976078337 hasConcept C2992379925 @default.
• W2976078337 hasConcept C55493867 @default.
• W2976078337 hasConcept C71924100 @default.
• W2976078337 hasConcept C84393581 @default.
• W2976078337 hasConcept C87644729 @default.
• W2976078337 hasConcept C97320921 @default.
• W2976078337 hasConcept C98274493 @default.
• W2976078337 hasConceptScore W2976078337C112705442 @default.
• W2976078337 hasConceptScore W2976078337C126322002 @default.
• W2976078337 hasConceptScore W2976078337C181199279 @default.
• W2976078337 hasConceptScore W2976078337C185592680 @default.
• W2976078337 hasConceptScore W2976078337C2777056448 @default.
• W2976078337 hasConceptScore W2976078337C2777482532 @default.
• W2976078337 hasConceptScore W2976078337C2779646130 @default.
• W2976078337 hasConceptScore W2976078337C2992379925 @default.
• W2976078337 hasConceptScore W2976078337C55493867 @default.
• W2976078337 hasConceptScore W2976078337C71924100 @default.
• W2976078337 hasConceptScore W2976078337C84393581 @default.
• W2976078337 hasConceptScore W2976078337C87644729 @default.
• W2976078337 hasConceptScore W2976078337C97320921 @default.
• W2976078337 hasConceptScore W2976078337C98274493 @default.
• W2976078337 hasIssue "6" @default.
• W2976078337 hasLocation W29760783371 @default.
• W2976078337 hasLocation W29760783372 @default.
• W2976078337 hasOpenAccess W2976078337 @default.
• W2976078337 hasPrimaryLocation W29760783371 @default.
• W2976078337 hasRelatedWork W1566015146 @default.
• W2976078337 hasRelatedWork W1978502180 @default.
• W2976078337 hasRelatedWork W2036343764 @default.
• W2976078337 hasRelatedWork W2124775757 @default.
• W2976078337 hasRelatedWork W2146507402 @default.
• W2976078337 hasRelatedWork W2312768630 @default.
• W2976078337 hasRelatedWork W2385472588 @default.
• W2976078337 hasRelatedWork W2605594768 @default.
• W2976078337 hasRelatedWork W2923907295 @default.
• W2976078337 hasRelatedWork W2976078337 @default.
• W2976078337 hasVolume "50" @default.
• W2976078337 isParatext "false" @default.
• W2976078337 isRetracted "false" @default.

• next