FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2976098312> ?p ?o ?g. }

• W2976098312 endingPage "e0222697" @default.
• W2976098312 startingPage "e0222697" @default.
• W2976098312 abstract "Dendritic cells (DCs) are professional antigen presenting cells involved in the induction of T cell-mediated adaptive immunity. Plasmacytoid DCs (pDCs) originate from lymphoid precursors and produce type I interferons (IFNs) in response to pathogens. A20 is considered as a negative regulator of toll-like receptor (TLR) signaling pathways, in which Toxoplasma gondii- derived profilin (TgPRF) is a TLR11/12 ligand recognised by DCs to stimulate their maturation/activation. Little is known about contributions of A20 to changes in biological properties of pDCs. The present study, therefore, explored whether pDC functions are influenced by A20. To this end, bone marrow cells were isolated and cultured with Flt3L to attain CD8DCs, CD11bDCs and pDCs and followed by challenge with TgPRP in the presence or absence of A20 siRNA. Expression of maturation markers were analysed by flow cytometry, and secretion of inflammatory cytokines by ELISA, cell migration by a transwell migration assay and expression of signalling molecules by western blotting. As a result, treatment with A20 siRNA enhanced activations of IκB-α and STAT-1, leading to increases in expressions of maturation markers and cytokine productions as well as migration of TgPRP-treated pDCs, while mature CD11bDCs produced at higher levels of TNF-α and IL-6 only. In addition, functions of CD8DCs remained unaltered following A20 silencing. The effects of A20 on pDC maturation and activation were completely abolished by IKK inhibitor and partially blunted by fludarabine. In conclusion, the inhibitory effects of A20 on pDC functions are expected to affect the immune response in T. gondii infection." @default.
• W2976098312 created "2019-10-03" @default.
• W2976098312 creator A5013152946 @default.
• W2976098312 creator A5020142607 @default.
• W2976098312 creator A5031128196 @default.
• W2976098312 creator A5043601320 @default.
• W2976098312 creator A5044887879 @default.
• W2976098312 creator A5051705611 @default.
• W2976098312 date "2019-09-23" @default.
• W2976098312 modified "2023-09-27" @default.
• W2976098312 title "Regulation of NF-κB- and STAT1-mediated plasmacytoid dendritic cell functions by A20" @default.
• W2976098312 cites W1493618707 @default.
• W2976098312 cites W1580262749 @default.
• W2976098312 cites W1592667222 @default.
• W2976098312 cites W1646363625 @default.
• W2976098312 cites W1793115003 @default.
• W2976098312 cites W1794982713 @default.
• W2976098312 cites W1911438026 @default.
• W2976098312 cites W1987371296 @default.
• W2976098312 cites W1993936200 @default.
• W2976098312 cites W1999227957 @default.
• W2976098312 cites W2009521410 @default.
• W2976098312 cites W2045303929 @default.
• W2976098312 cites W2049657896 @default.
• W2976098312 cites W2066013154 @default.
• W2976098312 cites W2079580116 @default.
• W2976098312 cites W2081982376 @default.
• W2976098312 cites W2090194051 @default.
• W2976098312 cites W2111200149 @default.
• W2976098312 cites W2111220263 @default.
• W2976098312 cites W2111260918 @default.
• W2976098312 cites W2112709575 @default.
• W2976098312 cites W2127035623 @default.
• W2976098312 cites W2130985618 @default.
• W2976098312 cites W2138298091 @default.
• W2976098312 cites W2158722408 @default.
• W2976098312 cites W2161472648 @default.
• W2976098312 cites W2186810526 @default.
• W2976098312 cites W2333852990 @default.
• W2976098312 cites W2511331982 @default.
• W2976098312 cites W2517849800 @default.
• W2976098312 cites W2740325876 @default.
• W2976098312 cites W2758914096 @default.
• W2976098312 doi "https://doi.org/10.1371/journal.pone.0222697" @default.
• W2976098312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6756537" @default.
• W2976098312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31545817" @default.
• W2976098312 hasPublicationYear "2019" @default.
• W2976098312 type Work @default.
• W2976098312 sameAs 2976098312 @default.
• W2976098312 citedByCount "5" @default.
• W2976098312 countsByYear W29760983122019 @default.
• W2976098312 countsByYear W29760983122020 @default.
• W2976098312 countsByYear W29760983122021 @default.
• W2976098312 countsByYear W29760983122022 @default.
• W2976098312 countsByYear W29760983122023 @default.
• W2976098312 crossrefType "journal-article" @default.
• W2976098312 hasAuthorship W2976098312A5013152946 @default.
• W2976098312 hasAuthorship W2976098312A5020142607 @default.
• W2976098312 hasAuthorship W2976098312A5031128196 @default.
• W2976098312 hasAuthorship W2976098312A5043601320 @default.
• W2976098312 hasAuthorship W2976098312A5044887879 @default.
• W2976098312 hasAuthorship W2976098312A5051705611 @default.
• W2976098312 hasBestOaLocation W29760983121 @default.
• W2976098312 hasConcept C104317684 @default.
• W2976098312 hasConcept C119056186 @default.
• W2976098312 hasConcept C193419808 @default.
• W2976098312 hasConcept C203014093 @default.
• W2976098312 hasConcept C2778170410 @default.
• W2976098312 hasConcept C2778690821 @default.
• W2976098312 hasConcept C49039625 @default.
• W2976098312 hasConcept C553184892 @default.
• W2976098312 hasConcept C55493867 @default.
• W2976098312 hasConcept C86803240 @default.
• W2976098312 hasConcept C8891405 @default.
• W2976098312 hasConcept C95444343 @default.
• W2976098312 hasConceptScore W2976098312C104317684 @default.
• W2976098312 hasConceptScore W2976098312C119056186 @default.
• W2976098312 hasConceptScore W2976098312C193419808 @default.
• W2976098312 hasConceptScore W2976098312C203014093 @default.
• W2976098312 hasConceptScore W2976098312C2778170410 @default.
• W2976098312 hasConceptScore W2976098312C2778690821 @default.
• W2976098312 hasConceptScore W2976098312C49039625 @default.
• W2976098312 hasConceptScore W2976098312C553184892 @default.
• W2976098312 hasConceptScore W2976098312C55493867 @default.
• W2976098312 hasConceptScore W2976098312C86803240 @default.
• W2976098312 hasConceptScore W2976098312C8891405 @default.
• W2976098312 hasConceptScore W2976098312C95444343 @default.
• W2976098312 hasFunder F4320309617 @default.
• W2976098312 hasIssue "9" @default.
• W2976098312 hasLocation W29760983121 @default.
• W2976098312 hasLocation W29760983122 @default.
• W2976098312 hasLocation W29760983123 @default.
• W2976098312 hasLocation W29760983124 @default.
• W2976098312 hasLocation W29760983125 @default.
• W2976098312 hasOpenAccess W2976098312 @default.
• W2976098312 hasPrimaryLocation W29760983121 @default.
• W2976098312 hasRelatedWork W181678093 @default.
• W2976098312 hasRelatedWork W2005666125 @default.

• next