FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2976153929> ?p ?o ?g. }

• W2976153929 endingPage "1431" @default.
• W2976153929 startingPage "1431" @default.
• W2976153929 abstract "The ICARUS trial is a phase II, open label, multicenter, single arm study conducted to investigate the efficacy, safety, and tolerability of a rechallenge treatment with the first-generation tyrosine kinase inhibitor (TKI) gefitinib in advanced non-small-cell lung cancer (NSCLC) patients carrying activating mutations of the epidermal growth factor receptor (EGFR). The ICARUS trial enrolled 61 patients who were rechallenged with gefitinib at progression after second-line chemotherapy. Serum-derived circulating cell-free DNA (cfDNA) collected before the rechallenge from a cohort of 29 patients, was retrospectively analyzed for the EGFR exon 19 deletions and for the p.L858R and p.T790M single nucleotide variants (SNV). The analysis of cfDNA detected the same EGFR activating mutation reported in the tumor tissue in 20/29 patients, with a sensitivity of 69%. Moreover, a p.T790M variant was found in 14/29 patients (48.3%). The median progression-free survival (PFS) was 2.7 months for p.T790M positive patients (CI 95% 1.4–3.1 months) versus 3.5 months for the p.T790M negative patients (CI 95% 1.6–5.3 months), resulting in a statistically significant difference (Long rank test p = 0.0180). These findings confirmed the role of the p.T790M mutation in the resistance to first-generation TKIs. More importantly, our data suggest that TKI rechallenge should be guided by biomarker testing." @default.
• W2976153929 created "2019-10-03" @default.
• W2976153929 creator A5001928949 @default.
• W2976153929 creator A5003014678 @default.
• W2976153929 creator A5003664573 @default.
• W2976153929 creator A5015633747 @default.
• W2976153929 creator A5017416242 @default.
• W2976153929 creator A5021264126 @default.
• W2976153929 creator A5023227998 @default.
• W2976153929 creator A5024088672 @default.
• W2976153929 creator A5028510503 @default.
• W2976153929 creator A5032887264 @default.
• W2976153929 creator A5045416042 @default.
• W2976153929 creator A5051933262 @default.
• W2976153929 creator A5052190218 @default.
• W2976153929 creator A5058327281 @default.
• W2976153929 creator A5062149201 @default.
• W2976153929 creator A5068497911 @default.
• W2976153929 creator A5071783009 @default.
• W2976153929 creator A5074010450 @default.
• W2976153929 creator A5085109152 @default.
• W2976153929 creator A5089891961 @default.
• W2976153929 date "2019-09-25" @default.
• W2976153929 modified "2023-09-26" @default.
• W2976153929 title "Liquid Biopsy Testing Can Improve Selection of Advanced Non-Small-Cell Lung Cancer Patients to Rechallenge With Gefitinib" @default.
• W2976153929 cites W1607191560 @default.
• W2976153929 cites W1920420394 @default.
• W2976153929 cites W1970538542 @default.
• W2976153929 cites W1980497534 @default.
• W2976153929 cites W2100409358 @default.
• W2976153929 cites W2163351155 @default.
• W2976153929 cites W2167948710 @default.
• W2976153929 cites W2425508265 @default.
• W2976153929 cites W2468983064 @default.
• W2976153929 cites W2489373060 @default.
• W2976153929 cites W2529451992 @default.
• W2976153929 cites W2561565091 @default.
• W2976153929 cites W2563674445 @default.
• W2976153929 cites W2567467789 @default.
• W2976153929 cites W2619372531 @default.
• W2976153929 cites W2718156733 @default.
• W2976153929 cites W2761792472 @default.
• W2976153929 cites W2762423488 @default.
• W2976153929 cites W2810788886 @default.
• W2976153929 cites W2901652911 @default.
• W2976153929 cites W2920175805 @default.
• W2976153929 cites W2941031840 @default.
• W2976153929 cites W4210992155 @default.
• W2976153929 doi "https://doi.org/10.3390/cancers11101431" @default.
• W2976153929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6826724" @default.
• W2976153929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31557965" @default.
• W2976153929 hasPublicationYear "2019" @default.
• W2976153929 type Work @default.
• W2976153929 sameAs 2976153929 @default.
• W2976153929 citedByCount "6" @default.
• W2976153929 countsByYear W29761539292020 @default.
• W2976153929 countsByYear W29761539292021 @default.
• W2976153929 countsByYear W29761539292022 @default.
• W2976153929 crossrefType "journal-article" @default.
• W2976153929 hasAuthorship W2976153929A5001928949 @default.
• W2976153929 hasAuthorship W2976153929A5003014678 @default.
• W2976153929 hasAuthorship W2976153929A5003664573 @default.
• W2976153929 hasAuthorship W2976153929A5015633747 @default.
• W2976153929 hasAuthorship W2976153929A5017416242 @default.
• W2976153929 hasAuthorship W2976153929A5021264126 @default.
• W2976153929 hasAuthorship W2976153929A5023227998 @default.
• W2976153929 hasAuthorship W2976153929A5024088672 @default.
• W2976153929 hasAuthorship W2976153929A5028510503 @default.
• W2976153929 hasAuthorship W2976153929A5032887264 @default.
• W2976153929 hasAuthorship W2976153929A5045416042 @default.
• W2976153929 hasAuthorship W2976153929A5051933262 @default.
• W2976153929 hasAuthorship W2976153929A5052190218 @default.
• W2976153929 hasAuthorship W2976153929A5058327281 @default.
• W2976153929 hasAuthorship W2976153929A5062149201 @default.
• W2976153929 hasAuthorship W2976153929A5068497911 @default.
• W2976153929 hasAuthorship W2976153929A5071783009 @default.
• W2976153929 hasAuthorship W2976153929A5074010450 @default.
• W2976153929 hasAuthorship W2976153929A5085109152 @default.
• W2976153929 hasAuthorship W2976153929A5089891961 @default.
• W2976153929 hasBestOaLocation W29761539291 @default.
• W2976153929 hasConcept C121608353 @default.
• W2976153929 hasConcept C126322002 @default.
• W2976153929 hasConcept C143998085 @default.
• W2976153929 hasConcept C197934379 @default.
• W2976153929 hasConcept C2776256026 @default.
• W2976153929 hasConcept C2777930144 @default.
• W2976153929 hasConcept C2778375690 @default.
• W2976153929 hasConcept C2779438470 @default.
• W2976153929 hasConcept C2779529041 @default.
• W2976153929 hasConcept C2780580887 @default.
• W2976153929 hasConcept C2781197716 @default.
• W2976153929 hasConcept C55493867 @default.
• W2976153929 hasConcept C71924100 @default.
• W2976153929 hasConcept C86803240 @default.
• W2976153929 hasConceptScore W2976153929C121608353 @default.
• W2976153929 hasConceptScore W2976153929C126322002 @default.
• W2976153929 hasConceptScore W2976153929C143998085 @default.
• W2976153929 hasConceptScore W2976153929C197934379 @default.

• next