Matches in SemOpenAlex for { <https://semopenalex.org/work/W2976187234> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2976187234 endingPage "117" @default.
- W2976187234 startingPage "111" @default.
- W2976187234 abstract "Abstract Background Autophagy is known as an intracellular cleanup system necessary to maintain homeostasis of the skin. Many studies have pointed out the relationship between aging and the inactivation of autophagy function, which suggests that the inactivation of autophagy occurs in aged skin. However, the aging process of the skin is complicated compared with other organs, because the skin is localized at the border between the inside of the body and the environment. Thus, skin aging is strongly affected by environmental factors, and it is well recognized that ultraviolet (UV) radiation is an important environmental factor that promotes skin aging. Therefore, characterizing the autophagic phenotypes induced by environmental factors is important to understand the process of skin aging. Methods In order to demonstrate the status of autophagy during environment‐induced aging of the skin, we investigated the autophagy profiles of normal human dermal fibroblasts (NHDFs) treated with repetitive UVA irradiation as model fibroblasts in photoaged skin. Results Repetitively UVA‐irradiated NHDFs showed increased numbers of autophagosomes, which coincided with the accumulation of p62 and increased levels of LAMP‐1 and lysosomes. The behavior of repetitively UVA‐irradiated NHDFs on autophagy was similar to that of NHDFs treated with hydroxychloroquine (HCQ), which is an inhibitor of lysosomal proteinase. Conclusion In summary, these results demonstrate that repetitively UVA‐irradiated fibroblasts have reduced autophagy function due to the dysfunction of lysosomes." @default.
- W2976187234 created "2019-10-03" @default.
- W2976187234 creator A5003721547 @default.
- W2976187234 creator A5021570930 @default.
- W2976187234 creator A5026938633 @default.
- W2976187234 creator A5074285103 @default.
- W2976187234 creator A5078181912 @default.
- W2976187234 creator A5081855393 @default.
- W2976187234 date "2019-10-16" @default.
- W2976187234 modified "2023-09-30" @default.
- W2976187234 title "Impairment of the autophagy system in repetitively UVA‐irradiated fibroblasts" @default.
- W2976187234 cites W1971782825 @default.
- W2976187234 cites W1975915706 @default.
- W2976187234 cites W1977767269 @default.
- W2976187234 cites W1993431505 @default.
- W2976187234 cites W1996537328 @default.
- W2976187234 cites W2001239820 @default.
- W2976187234 cites W2001591494 @default.
- W2976187234 cites W2038592957 @default.
- W2976187234 cites W2047316426 @default.
- W2976187234 cites W2048657237 @default.
- W2976187234 cites W2062028090 @default.
- W2976187234 cites W2083538530 @default.
- W2976187234 cites W2104908670 @default.
- W2976187234 cites W2128101513 @default.
- W2976187234 cites W2146124002 @default.
- W2976187234 cites W2166053364 @default.
- W2976187234 cites W2749067209 @default.
- W2976187234 doi "https://doi.org/10.1111/phpp.12516" @default.
- W2976187234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31553079" @default.
- W2976187234 hasPublicationYear "2019" @default.
- W2976187234 type Work @default.
- W2976187234 sameAs 2976187234 @default.
- W2976187234 citedByCount "6" @default.
- W2976187234 countsByYear W29761872342020 @default.
- W2976187234 countsByYear W29761872342021 @default.
- W2976187234 countsByYear W29761872342022 @default.
- W2976187234 countsByYear W29761872342023 @default.
- W2976187234 crossrefType "journal-article" @default.
- W2976187234 hasAuthorship W2976187234A5003721547 @default.
- W2976187234 hasAuthorship W2976187234A5021570930 @default.
- W2976187234 hasAuthorship W2976187234A5026938633 @default.
- W2976187234 hasAuthorship W2976187234A5074285103 @default.
- W2976187234 hasAuthorship W2976187234A5078181912 @default.
- W2976187234 hasAuthorship W2976187234A5081855393 @default.
- W2976187234 hasConcept C16005928 @default.
- W2976187234 hasConcept C185592680 @default.
- W2976187234 hasConcept C190283241 @default.
- W2976187234 hasConcept C203522944 @default.
- W2976187234 hasConcept C2777459323 @default.
- W2976187234 hasConcept C2909910311 @default.
- W2976187234 hasConcept C502942594 @default.
- W2976187234 hasConcept C54355233 @default.
- W2976187234 hasConcept C55493867 @default.
- W2976187234 hasConcept C71924100 @default.
- W2976187234 hasConcept C79879829 @default.
- W2976187234 hasConcept C86803240 @default.
- W2976187234 hasConcept C95444343 @default.
- W2976187234 hasConceptScore W2976187234C16005928 @default.
- W2976187234 hasConceptScore W2976187234C185592680 @default.
- W2976187234 hasConceptScore W2976187234C190283241 @default.
- W2976187234 hasConceptScore W2976187234C203522944 @default.
- W2976187234 hasConceptScore W2976187234C2777459323 @default.
- W2976187234 hasConceptScore W2976187234C2909910311 @default.
- W2976187234 hasConceptScore W2976187234C502942594 @default.
- W2976187234 hasConceptScore W2976187234C54355233 @default.
- W2976187234 hasConceptScore W2976187234C55493867 @default.
- W2976187234 hasConceptScore W2976187234C71924100 @default.
- W2976187234 hasConceptScore W2976187234C79879829 @default.
- W2976187234 hasConceptScore W2976187234C86803240 @default.
- W2976187234 hasConceptScore W2976187234C95444343 @default.
- W2976187234 hasIssue "2" @default.
- W2976187234 hasLocation W29761872341 @default.
- W2976187234 hasLocation W29761872342 @default.
- W2976187234 hasOpenAccess W2976187234 @default.
- W2976187234 hasPrimaryLocation W29761872341 @default.
- W2976187234 hasRelatedWork W1549554643 @default.
- W2976187234 hasRelatedWork W1976302891 @default.
- W2976187234 hasRelatedWork W2001675597 @default.
- W2976187234 hasRelatedWork W2042260827 @default.
- W2976187234 hasRelatedWork W2114330152 @default.
- W2976187234 hasRelatedWork W214686084 @default.
- W2976187234 hasRelatedWork W2177503603 @default.
- W2976187234 hasRelatedWork W2369447788 @default.
- W2976187234 hasRelatedWork W2371213103 @default.
- W2976187234 hasRelatedWork W4283822279 @default.
- W2976187234 hasVolume "36" @default.
- W2976187234 isParatext "false" @default.
- W2976187234 isRetracted "false" @default.
- W2976187234 magId "2976187234" @default.
- W2976187234 workType "article" @default.