FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2976220968> ?p ?o ?g. }

• W2976220968 abstract "Insects can produce various antimicrobial peptides (AMPs) upon immune stimulation. One class of AMPs are characterized by their high proline content in certain fragments. They are generally called proline-rich antimicrobial peptides (PrAMPs). We previously reported the characterization of Spodoptera litura lebocin-1 (SlLeb-1), a PrAMP proprotein. Preliminary studies with synthetic polypeptides showed that among the four deductive active fragments, the C-terminal fragment SlLeb-1 (124-158) showed strong antibacterial activities. Here, we further characterized the antibacterial and antifungal activities of 124-158 and its four subfragments: 124-155, 124-149, 127-158, and 135-158. Only 124-158 and 127-158 could agglutinate bacteria, while 124-158 and four subfragments all could agglutinate Beauveria bassiana spores. Confocal microscopy showed that fluorescent peptides were located on the microbial surface. Fragment 135-158 lost activity completely against Escherichia coli and Staphylococcus aureus, and partially against Bacillus subtilis. Only 124-149 showed low activity against Serratia marcescens. Negative staining, transmission, and scanning electron microscopy of 124-158 treated bacteria showed different morphologies. Flow cytometry analysis of S. aureus showed that 124-158 and four subfragments changed bacterial subpopulations and caused an increase of DNA content. These results indicate that active fragments of SlLeb-1 may have diverse antimicrobial effects against different microbes. This study may provide an insight into the development of novel antimicrobial agents." @default.
• W2976220968 created "2019-10-03" @default.
• W2976220968 creator A5002303418 @default.
• W2976220968 creator A5003377806 @default.
• W2976220968 creator A5034071007 @default.
• W2976220968 creator A5045492403 @default.
• W2976220968 creator A5048564689 @default.
• W2976220968 creator A5066940695 @default.
• W2976220968 creator A5067525880 @default.
• W2976220968 creator A5076133947 @default.
• W2976220968 creator A5090744085 @default.
• W2976220968 date "2019-09-28" @default.
• W2976220968 modified "2023-09-26" @default.
• W2976220968 title "Characterization of the active fragments ofSpodoptera lituraLebocin‐1" @default.
• W2976220968 cites W1520392406 @default.
• W2976220968 cites W1522262409 @default.
• W2976220968 cites W1952159532 @default.
• W2976220968 cites W1963568761 @default.
• W2976220968 cites W197620025 @default.
• W2976220968 cites W1977276752 @default.
• W2976220968 cites W1977286327 @default.
• W2976220968 cites W1982095205 @default.
• W2976220968 cites W1986496696 @default.
• W2976220968 cites W1989998611 @default.
• W2976220968 cites W1996776475 @default.
• W2976220968 cites W2003810642 @default.
• W2976220968 cites W2036215819 @default.
• W2976220968 cites W2038208689 @default.
• W2976220968 cites W2041713760 @default.
• W2976220968 cites W2047256888 @default.
• W2976220968 cites W2049286054 @default.
• W2976220968 cites W2050644782 @default.
• W2976220968 cites W2053896110 @default.
• W2976220968 cites W2054607729 @default.
• W2976220968 cites W2058115755 @default.
• W2976220968 cites W2058429414 @default.
• W2976220968 cites W2060869974 @default.
• W2976220968 cites W2064768831 @default.
• W2976220968 cites W2065194192 @default.
• W2976220968 cites W2065645730 @default.
• W2976220968 cites W2065903733 @default.
• W2976220968 cites W2066785573 @default.
• W2976220968 cites W2068620810 @default.
• W2976220968 cites W2071146214 @default.
• W2976220968 cites W2079082114 @default.
• W2976220968 cites W2082270598 @default.
• W2976220968 cites W2086484104 @default.
• W2976220968 cites W2104189207 @default.
• W2976220968 cites W2106452753 @default.
• W2976220968 cites W2116963349 @default.
• W2976220968 cites W2119834790 @default.
• W2976220968 cites W2142168525 @default.
• W2976220968 cites W2147574532 @default.
• W2976220968 cites W2167302836 @default.
• W2976220968 cites W2193992800 @default.
• W2976220968 cites W2217873281 @default.
• W2976220968 cites W2244307256 @default.
• W2976220968 cites W2257180174 @default.
• W2976220968 cites W2297420302 @default.
• W2976220968 cites W2410974586 @default.
• W2976220968 cites W2519208473 @default.
• W2976220968 cites W2580811139 @default.
• W2976220968 cites W2586156886 @default.
• W2976220968 cites W2593255057 @default.
• W2976220968 cites W2619787325 @default.
• W2976220968 cites W2773986836 @default.
• W2976220968 cites W2808984886 @default.
• W2976220968 cites W2809478061 @default.
• W2976220968 cites W2897117998 @default.
• W2976220968 cites W2900617177 @default.
• W2976220968 cites W2912990441 @default.
• W2976220968 cites W2936102562 @default.
• W2976220968 cites W2938574745 @default.
• W2976220968 cites W2946654535 @default.
• W2976220968 doi "https://doi.org/10.1002/arch.21626" @default.
• W2976220968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31562754" @default.
• W2976220968 hasPublicationYear "2019" @default.
• W2976220968 type Work @default.
• W2976220968 sameAs 2976220968 @default.
• W2976220968 citedByCount "6" @default.
• W2976220968 countsByYear W29762209682020 @default.
• W2976220968 countsByYear W29762209682021 @default.
• W2976220968 countsByYear W29762209682022 @default.
• W2976220968 countsByYear W29762209682023 @default.
• W2976220968 crossrefType "journal-article" @default.
• W2976220968 hasAuthorship W2976220968A5002303418 @default.
• W2976220968 hasAuthorship W2976220968A5003377806 @default.
• W2976220968 hasAuthorship W2976220968A5034071007 @default.
• W2976220968 hasAuthorship W2976220968A5045492403 @default.
• W2976220968 hasAuthorship W2976220968A5048564689 @default.
• W2976220968 hasAuthorship W2976220968A5066940695 @default.
• W2976220968 hasAuthorship W2976220968A5067525880 @default.
• W2976220968 hasAuthorship W2976220968A5076133947 @default.
• W2976220968 hasAuthorship W2976220968A5090744085 @default.
• W2976220968 hasConcept C104317684 @default.
• W2976220968 hasConcept C153911025 @default.
• W2976220968 hasConcept C2776309202 @default.
• W2976220968 hasConcept C2776683811 @default.
• W2976220968 hasConcept C2777272437 @default.
• W2976220968 hasConcept C2779489039 @default.

• next