FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2976223855> ?p ?o ?g. }

• W2976223855 endingPage "7973" @default.
• W2976223855 startingPage "7963" @default.
• W2976223855 abstract "This study was designed to expound the underlying mechanism of microtubule-directed chemotherapeutic drugs resistance induced by cancer-associated fibroblasts (CAFs) in breast cancer.We collected 10 microtubule-directed chemotherapeutic drugs resistant breast tumor samples and 10 normal breast tumor samples to analyze the CAFs distribution by immunohistochemistry and flow cytometry. We also detected the collagen expression in CAFs by real-time PCR. We detected the activation of PI3K/AKT signaling pathway in tumor cells by Western blotting and immunofluorescence. The subcutaneous 4T1/MCF-7 bearing mice were used to investigate the anticancer effects of integrin β1 inhibitor combined with microtubule-directed chemotherapeutic drugs.In our studies, accumulation of CAFs was observed in tumor samples from microtubule-directed chemotherapeutic drugs resistant patients. Those isolated CAFs could efficiently induce the acquisition of microtubule-directed chemotherapeutic drugs resistance in breast cancer cells. More importantly, we found that CAFs could regulate the microtubule-directed chemotherapeutic drugs resistance through the secretion of collagen to activate the integrin β1/PI3K/AKT signaling pathway. Combination of integrin α2β1 inhibitor and paclitaxel/vincristine sulfate could efficiently overcome the microtubule-directed chemotherapeutic drugs resistance induced by CAFs and enhanced the anticancer effects of chemotherapy in subcutaneous 4T1/MCF-7 bearing mice.Our results demonstrated that CAFs constitute a supporting niche for cancer drug resistance acquisition. Thus, traditional microtubule-directed chemotherapeutic drugs combined with integrin β1 inhibitor may present an innovative therapeutic strategy for breast cancer therapy." @default.
• W2976223855 created "2019-10-03" @default.
• W2976223855 creator A5006226852 @default.
• W2976223855 creator A5014691173 @default.
• W2976223855 creator A5018221219 @default.
• W2976223855 creator A5035301810 @default.
• W2976223855 creator A5069771802 @default.
• W2976223855 date "2019-09-01" @default.
• W2976223855 modified "2023-10-10" @default.
• W2976223855 title "<p>Reverse of microtubule-directed chemotherapeutic drugs resistance induced by cancer-associated fibroblasts in breast cancer</p>" @default.
• W2976223855 cites W1736125567 @default.
• W2976223855 cites W1971649337 @default.
• W2976223855 cites W2003562401 @default.
• W2976223855 cites W2013381560 @default.
• W2976223855 cites W2048993476 @default.
• W2976223855 cites W2105968397 @default.
• W2976223855 cites W2109995938 @default.
• W2976223855 cites W2110957241 @default.
• W2976223855 cites W2167380395 @default.
• W2976223855 cites W2171549753 @default.
• W2976223855 cites W2269768516 @default.
• W2976223855 cites W2272984102 @default.
• W2976223855 cites W2342880373 @default.
• W2976223855 cites W2396078839 @default.
• W2976223855 cites W2476542314 @default.
• W2976223855 cites W2512899508 @default.
• W2976223855 cites W2547358231 @default.
• W2976223855 cites W2607992798 @default.
• W2976223855 cites W2729424069 @default.
• W2976223855 cites W2742147437 @default.
• W2976223855 cites W2762481118 @default.
• W2976223855 cites W2765877408 @default.
• W2976223855 cites W2769978286 @default.
• W2976223855 cites W2772615438 @default.
• W2976223855 cites W2773338411 @default.
• W2976223855 cites W2791022996 @default.
• W2976223855 cites W2793444560 @default.
• W2976223855 cites W2260502194 @default.
• W2976223855 doi "https://doi.org/10.2147/ott.s211043" @default.
• W2976223855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6773970" @default.
• W2976223855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31579239" @default.
• W2976223855 hasPublicationYear "2019" @default.
• W2976223855 type Work @default.
• W2976223855 sameAs 2976223855 @default.
• W2976223855 citedByCount "7" @default.
• W2976223855 countsByYear W29762238552020 @default.
• W2976223855 countsByYear W29762238552021 @default.
• W2976223855 countsByYear W29762238552022 @default.
• W2976223855 countsByYear W29762238552023 @default.
• W2976223855 crossrefType "journal-article" @default.
• W2976223855 hasAuthorship W2976223855A5006226852 @default.
• W2976223855 hasAuthorship W2976223855A5014691173 @default.
• W2976223855 hasAuthorship W2976223855A5018221219 @default.
• W2976223855 hasAuthorship W2976223855A5035301810 @default.
• W2976223855 hasAuthorship W2976223855A5069771802 @default.
• W2976223855 hasBestOaLocation W29762238551 @default.
• W2976223855 hasConcept C114851261 @default.
• W2976223855 hasConcept C121608353 @default.
• W2976223855 hasConcept C126322002 @default.
• W2976223855 hasConcept C20418707 @default.
• W2976223855 hasConcept C2777292972 @default.
• W2976223855 hasConcept C2909706936 @default.
• W2976223855 hasConcept C502942594 @default.
• W2976223855 hasConcept C530470458 @default.
• W2976223855 hasConcept C62478195 @default.
• W2976223855 hasConcept C71924100 @default.
• W2976223855 hasConcept C75217442 @default.
• W2976223855 hasConcept C86554907 @default.
• W2976223855 hasConcept C86803240 @default.
• W2976223855 hasConcept C89423630 @default.
• W2976223855 hasConcept C95444343 @default.
• W2976223855 hasConcept C96232424 @default.
• W2976223855 hasConcept C98274493 @default.
• W2976223855 hasConceptScore W2976223855C114851261 @default.
• W2976223855 hasConceptScore W2976223855C121608353 @default.
• W2976223855 hasConceptScore W2976223855C126322002 @default.
• W2976223855 hasConceptScore W2976223855C20418707 @default.
• W2976223855 hasConceptScore W2976223855C2777292972 @default.
• W2976223855 hasConceptScore W2976223855C2909706936 @default.
• W2976223855 hasConceptScore W2976223855C502942594 @default.
• W2976223855 hasConceptScore W2976223855C530470458 @default.
• W2976223855 hasConceptScore W2976223855C62478195 @default.
• W2976223855 hasConceptScore W2976223855C71924100 @default.
• W2976223855 hasConceptScore W2976223855C75217442 @default.
• W2976223855 hasConceptScore W2976223855C86554907 @default.
• W2976223855 hasConceptScore W2976223855C86803240 @default.
• W2976223855 hasConceptScore W2976223855C89423630 @default.
• W2976223855 hasConceptScore W2976223855C95444343 @default.
• W2976223855 hasConceptScore W2976223855C96232424 @default.
• W2976223855 hasConceptScore W2976223855C98274493 @default.
• W2976223855 hasLocation W29762238551 @default.
• W2976223855 hasLocation W29762238552 @default.
• W2976223855 hasLocation W29762238553 @default.
• W2976223855 hasLocation W29762238554 @default.
• W2976223855 hasOpenAccess W2976223855 @default.
• W2976223855 hasPrimaryLocation W29762238551 @default.
• W2976223855 hasRelatedWork W1406632 @default.
• W2976223855 hasRelatedWork W1582696369 @default.

• next