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• W2976287447 startingPage "3069" @default.
• W2976287447 abstract "Abstract Children are more sensitive than adults to bitterness and thus dislike bitter tastes more than adults do. However, why children are more sensitive to bitterness has never been revealed. To elucidate the effects of age on taste perception, a double‐bottle preference test was first performed with immature and adult rats. Then, RNA‐Seq analysis was performed on tongues obtained from rats of the same ages as those in the double‐bottle test. The immature rats exhibited a lower consumption rate of bitter solution than the adult rats. Bioinformatics analysis yielded 1,347 differentially expressed genes (DEGs) between male adult rats (MARs, 80 days old) and male immature rats (MIRs, 20 days old) and 380 DEGs between female adult rats (FARs, 80 days old) and female immature rats (FIRs, 20 days old). These DEGs were mainly associated with growth, development, differentiation, and extracellular processes, among other mechanisms. According to Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the DEGs were enriched for bitter taste transduction. Specifically, the Gnb3 and TRPM5 genes were downregulated in FARs compared with FIRs and in MARs compared with MIRs, and the protein expression of TRPM5 was significantly downregulated in MARs compared with MIRs. The data presented herein suggest that transcriptional regulation of taste‐associated signal transduction occurs differently in tongue epithelial tissue of rats at different ages, although additional analyses are needed to confirm this conclusion." @default.
• W2976287447 created "2019-10-03" @default.
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• W2976287447 date "2019-09-23" @default.
• W2976287447 modified "2023-10-14" @default.
• W2976287447 title "Transcriptional profiling of genes in tongue epithelial tissue from immature and adult rats by the RNA‐Seq technique" @default.
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• W2976287447 doi "https://doi.org/10.1002/jcp.29211" @default.
• W2976287447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31549403" @default.
• W2976287447 hasPublicationYear "2019" @default.
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