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• W2976386749 endingPage "1009" @default.
• W2976386749 startingPage "1009" @default.
• W2976386749 abstract "The present study aimed to investigate the effect of melatonin (MT) supplementation on in vitro maturation of vitrified mouse germinal vesicle (GV) oocytes. The fresh oocytes were randomly divided into three groups: untreated (control), or vitrified by open-pulled straw method without (vitrification group) or with MT supplementation (vitrification + MT group). After warming, oocytes were cultured in vitro, then the reactive oxygen species (ROS) and glutathione (GSH) levels, mitochondrial membrane potential, ATP levels, spindle morphology, mRNA expression of spindle assembly checkpoint (SAC)-related genes (Mps1, BubR1, Mad1, Mad2), and their subsequent developmental potential in vitro were evaluated. The results showed that vitrification/warming procedures significantly decreased the percentage of GV oocytes developed to metaphase II (MII) stage, the mitochondrial membrane potential, ATP content, and GSH levels, remarkably increased the ROS levels, and significantly impaired the spindle morphology. The expressions of SAC-related genes were also altered in vitrified oocytes. However, when 10−7 mol/L MT was administered during the whole length of the experiment, the percentage of GV oocytes matured to MII stage was significantly increased, and the other indicators were also significantly improved and almost recovered to the normal levels relative to the control. Thus, we speculate that MT might regulate the mitochondrial membrane potential, ATP content, ROS, GSH, and expression of SAC-related genes, potentially increasing the in vitro maturation of vitrified-warmed mouse GV oocytes." @default.
• W2976386749 created "2019-10-03" @default.
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• W2976386749 creator A5090695125 @default.
• W2976386749 date "2019-08-30" @default.
• W2976386749 modified "2023-10-03" @default.
• W2976386749 title "Melatonin Improves In Vitro Development of Vitrified-Warmed Mouse Germinal Vesicle Oocytes Potentially via Modulation of Spindle Assembly Checkpoint-Related Genes" @default.
• W2976386749 cites W1080136797 @default.
• W2976386749 cites W113581348 @default.
• W2976386749 cites W1601279429 @default.
• W2976386749 cites W1795765514 @default.
• W2976386749 cites W1861768187 @default.
• W2976386749 cites W1909004466 @default.
• W2976386749 cites W1966263664 @default.
• W2976386749 cites W1970423327 @default.
• W2976386749 cites W1971022983 @default.
• W2976386749 cites W1974377458 @default.
• W2976386749 cites W1985966233 @default.
• W2976386749 cites W1991762116 @default.
• W2976386749 cites W1997528931 @default.
• W2976386749 cites W2002841191 @default.
• W2976386749 cites W2006325596 @default.
• W2976386749 cites W2008905107 @default.
• W2976386749 cites W2009146209 @default.
• W2976386749 cites W2009455793 @default.
• W2976386749 cites W2010614833 @default.
• W2976386749 cites W2015041153 @default.
• W2976386749 cites W2020137180 @default.
• W2976386749 cites W2026082686 @default.
• W2976386749 cites W2026223997 @default.
• W2976386749 cites W2027686487 @default.
• W2976386749 cites W2042300950 @default.
• W2976386749 cites W2053829558 @default.
• W2976386749 cites W2054886999 @default.
• W2976386749 cites W2058367570 @default.
• W2976386749 cites W2060950890 @default.
• W2976386749 cites W2063539035 @default.
• W2976386749 cites W2069293047 @default.
• W2976386749 cites W2071278012 @default.
• W2976386749 cites W2073929868 @default.
• W2976386749 cites W2079887269 @default.
• W2976386749 cites W2087216852 @default.
• W2976386749 cites W2091365164 @default.
• W2976386749 cites W2097776522 @default.
• W2976386749 cites W2104036748 @default.
• W2976386749 cites W2107277218 @default.
• W2976386749 cites W2108612101 @default.
• W2976386749 cites W2113330309 @default.
• W2976386749 cites W2115719736 @default.
• W2976386749 cites W2119718277 @default.
• W2976386749 cites W2126726494 @default.
• W2976386749 cites W2129434699 @default.
• W2976386749 cites W2138586825 @default.
• W2976386749 cites W2140828323 @default.
• W2976386749 cites W2146041376 @default.
• W2976386749 cites W2147545348 @default.
• W2976386749 cites W2151261872 @default.
• W2976386749 cites W2153957603 @default.
• W2976386749 cites W2161002528 @default.
• W2976386749 cites W2162979714 @default.
• W2976386749 cites W2165835232 @default.
• W2976386749 cites W2181398221 @default.
• W2976386749 cites W2192080449 @default.
• W2976386749 cites W2232023980 @default.
• W2976386749 cites W2252828670 @default.
• W2976386749 cites W2293145779 @default.
• W2976386749 cites W2293379746 @default.
• W2976386749 cites W23079607 @default.
• W2976386749 cites W2402072938 @default.
• W2976386749 cites W2475806116 @default.
• W2976386749 cites W2511808216 @default.
• W2976386749 cites W2531387142 @default.
• W2976386749 cites W2554189630 @default.
• W2976386749 cites W2593681724 @default.
• W2976386749 cites W2594354691 @default.
• W2976386749 cites W2728715382 @default.
• W2976386749 cites W2763086570 @default.
• W2976386749 cites W2768125767 @default.
• W2976386749 cites W2773640064 @default.
• W2976386749 cites W2781731835 @default.
• W2976386749 cites W2791577574 @default.
• W2976386749 cites W2802151370 @default.
• W2976386749 cites W2802232727 @default.
• W2976386749 cites W2891503561 @default.
• W2976386749 cites W2899144263 @default.
• W2976386749 cites W2902395787 @default.
• W2976386749 cites W2904453101 @default.
• W2976386749 cites W2911098601 @default.

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