FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2976387010> ?p ?o ?g. }

• W2976387010 endingPage "368" @default.
• W2976387010 startingPage "357" @default.
• W2976387010 abstract "Purpose To investigate the role of sex on retinal nerve fiber layer (RNFL) thickness at 768 circumpapillary locations based on OCT findings. Design Population-based cross-sectional study. Participants We investigated 5646 eyes of 5646 healthy participants from the Leipzig Research Centre for Civilization Diseases (LIFE)-Adult Study of a predominantly white population. Methods All participants underwent standardized systemic assessments and ocular imaging. Circumpapillary RNFL (cRNFL) thickness was measured at 768 points equidistant from the optic nerve head using spectral-domain OCT (Spectralis; Heidelberg Engineering, Heidelberg, Germany). To control ocular magnification effects, the true scanning radius was estimated by scanning focus. Student t test was used to evaluate sex differences in cRNFL thickness globally and at each of the 768 locations. Multivariable linear regression and analysis of variance were used to evaluate individual contributions of various factors to cRNFL thickness variance. Main Outcome Measures Difference in cRNFL thickness between males and females. Results Our population consisted of 54.8% females. The global cRNFL thickness was 1 μm thicker in females (P < 0.001). However, detailed analysis at each of the 768 locations revealed substantial location specificity of the sex effects, with RNFL thickness difference ranging from –9.98 to +8.00 μm. Females showed significantly thicker RNFLs in the temporal, superotemporal, nasal, inferonasal, and inferotemporal regions (43.6% of 768 locations), whereas males showed significantly thicker RNFLs in the superior region (13.2%). The results were similar after adjusting for age, body height, and scanning radius. The superotemporal and inferotemporal RNFL peaks shifted temporally in females by 2.4° and 1.9°, respectively. On regions with significant sex effects, sex explained more RNFL thickness variance than age, whereas the major peak locations and interpeak angle explained most of the RNFL thickness variance unexplained by sex. Conclusions Substantial sex effects on cRNFL thickness were found at 56.8% of all 768 circumpapillary locations, with specific patterns for different sectors. Over large regions, sex was at least as important in explaining the cRNFL thickness variance as was age, which is well established to have a substantial impact on cRNFL thickness. Including sex in the cRNFL thickness norm could therefore improve glaucoma diagnosis and monitoring. To investigate the role of sex on retinal nerve fiber layer (RNFL) thickness at 768 circumpapillary locations based on OCT findings. Population-based cross-sectional study. We investigated 5646 eyes of 5646 healthy participants from the Leipzig Research Centre for Civilization Diseases (LIFE)-Adult Study of a predominantly white population. All participants underwent standardized systemic assessments and ocular imaging. Circumpapillary RNFL (cRNFL) thickness was measured at 768 points equidistant from the optic nerve head using spectral-domain OCT (Spectralis; Heidelberg Engineering, Heidelberg, Germany). To control ocular magnification effects, the true scanning radius was estimated by scanning focus. Student t test was used to evaluate sex differences in cRNFL thickness globally and at each of the 768 locations. Multivariable linear regression and analysis of variance were used to evaluate individual contributions of various factors to cRNFL thickness variance. Difference in cRNFL thickness between males and females. Our population consisted of 54.8% females. The global cRNFL thickness was 1 μm thicker in females (P < 0.001). However, detailed analysis at each of the 768 locations revealed substantial location specificity of the sex effects, with RNFL thickness difference ranging from –9.98 to +8.00 μm. Females showed significantly thicker RNFLs in the temporal, superotemporal, nasal, inferonasal, and inferotemporal regions (43.6% of 768 locations), whereas males showed significantly thicker RNFLs in the superior region (13.2%). The results were similar after adjusting for age, body height, and scanning radius. The superotemporal and inferotemporal RNFL peaks shifted temporally in females by 2.4° and 1.9°, respectively. On regions with significant sex effects, sex explained more RNFL thickness variance than age, whereas the major peak locations and interpeak angle explained most of the RNFL thickness variance unexplained by sex. Substantial sex effects on cRNFL thickness were found at 56.8% of all 768 circumpapillary locations, with specific patterns for different sectors. Over large regions, sex was at least as important in explaining the cRNFL thickness variance as was age, which is well established to have a substantial impact on cRNFL thickness. Including sex in the cRNFL thickness norm could therefore improve glaucoma diagnosis and monitoring." @default.
• W2976387010 created "2019-10-03" @default.
• W2976387010 creator A5002394702 @default.
• W2976387010 creator A5016092761 @default.
• W2976387010 creator A5018641933 @default.
• W2976387010 creator A5025964385 @default.
• W2976387010 creator A5027776523 @default.
• W2976387010 creator A5033292535 @default.
• W2976387010 creator A5041546200 @default.
• W2976387010 creator A5047341378 @default.
• W2976387010 creator A5047837989 @default.
• W2976387010 creator A5070233343 @default.
• W2976387010 creator A5072983273 @default.
• W2976387010 date "2020-03-01" @default.
• W2976387010 modified "2023-10-17" @default.
• W2976387010 title "Sex-Specific Differences in Circumpapillary Retinal Nerve Fiber Layer Thickness" @default.
• W2976387010 cites W1588434295 @default.
• W2976387010 cites W1599257541 @default.
• W2976387010 cites W1979321850 @default.
• W2976387010 cites W1985991393 @default.
• W2976387010 cites W1986860014 @default.
• W2976387010 cites W1994646223 @default.
• W2976387010 cites W2004301216 @default.
• W2976387010 cites W2004831648 @default.
• W2976387010 cites W2009348736 @default.
• W2976387010 cites W2015739996 @default.
• W2976387010 cites W2020731581 @default.
• W2976387010 cites W2021456784 @default.
• W2976387010 cites W2041002427 @default.
• W2976387010 cites W2043163806 @default.
• W2976387010 cites W2049782634 @default.
• W2976387010 cites W2062781757 @default.
• W2976387010 cites W2069087843 @default.
• W2976387010 cites W2071921468 @default.
• W2976387010 cites W2080872867 @default.
• W2976387010 cites W2081463022 @default.
• W2976387010 cites W2084414024 @default.
• W2976387010 cites W2090404086 @default.
• W2976387010 cites W2091832434 @default.
• W2976387010 cites W2109439880 @default.
• W2976387010 cites W2114259959 @default.
• W2976387010 cites W2116153835 @default.
• W2976387010 cites W2128304593 @default.
• W2976387010 cites W2158147305 @default.
• W2976387010 cites W2158770960 @default.
• W2976387010 cites W2166964727 @default.
• W2976387010 cites W2325153139 @default.
• W2976387010 cites W2342592237 @default.
• W2976387010 cites W2418802570 @default.
• W2976387010 cites W2581618655 @default.
• W2976387010 cites W2752747624 @default.
• W2976387010 cites W2763820101 @default.
• W2976387010 cites W2782844214 @default.
• W2976387010 cites W2898639674 @default.
• W2976387010 cites W2903546628 @default.
• W2976387010 cites W2912995336 @default.
• W2976387010 cites W2913473870 @default.
• W2976387010 doi "https://doi.org/10.1016/j.ophtha.2019.09.019" @default.
• W2976387010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7039768" @default.
• W2976387010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31732228" @default.
• W2976387010 hasPublicationYear "2020" @default.
• W2976387010 type Work @default.
• W2976387010 sameAs 2976387010 @default.
• W2976387010 citedByCount "31" @default.
• W2976387010 countsByYear W29763870102020 @default.
• W2976387010 countsByYear W29763870102021 @default.
• W2976387010 countsByYear W29763870102022 @default.
• W2976387010 countsByYear W29763870102023 @default.
• W2976387010 crossrefType "journal-article" @default.
• W2976387010 hasAuthorship W2976387010A5002394702 @default.
• W2976387010 hasAuthorship W2976387010A5016092761 @default.
• W2976387010 hasAuthorship W2976387010A5018641933 @default.
• W2976387010 hasAuthorship W2976387010A5025964385 @default.
• W2976387010 hasAuthorship W2976387010A5027776523 @default.
• W2976387010 hasAuthorship W2976387010A5033292535 @default.
• W2976387010 hasAuthorship W2976387010A5041546200 @default.
• W2976387010 hasAuthorship W2976387010A5047341378 @default.
• W2976387010 hasAuthorship W2976387010A5047837989 @default.
• W2976387010 hasAuthorship W2976387010A5070233343 @default.
• W2976387010 hasAuthorship W2976387010A5072983273 @default.
• W2976387010 hasBestOaLocation W29763870102 @default.
• W2976387010 hasConcept C118487528 @default.
• W2976387010 hasConcept C2780592520 @default.
• W2976387010 hasConcept C2780827179 @default.
• W2976387010 hasConcept C2908647359 @default.
• W2976387010 hasConcept C71924100 @default.
• W2976387010 hasConcept C99454951 @default.
• W2976387010 hasConceptScore W2976387010C118487528 @default.
• W2976387010 hasConceptScore W2976387010C2780592520 @default.
• W2976387010 hasConceptScore W2976387010C2780827179 @default.
• W2976387010 hasConceptScore W2976387010C2908647359 @default.
• W2976387010 hasConceptScore W2976387010C71924100 @default.
• W2976387010 hasConceptScore W2976387010C99454951 @default.
• W2976387010 hasFunder F4320306811 @default.
• W2976387010 hasFunder F4320308990 @default.
• W2976387010 hasFunder F4320320300 @default.
• W2976387010 hasFunder F4320332161 @default.
• W2976387010 hasFunder F4320335322 @default.

• next