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• W2976409404 abstract "Event Abstract Back to Event A systematic review and meta-analysis of delay to radical cystectomy and the effect on survival in bladder cancer patients Beth Russell1*, Fredrik Liedberg2, 3, Muhammad S. Khan4, Rajesh Nair4, Ramesh Thurairaja4, Sachin Malde4, Pardeep Kumar5 and Richard T. Bryan6 1 King's College London, United Kingdom 2 Department of Urology, Skåne University Hospital, Sweden 3 Department of Translational Medicine, Faculty of Medicine, Lund University, Sweden 4 Guy's Hospital, United Kingdom 5 Royal Marsden NHS Foundation Trust, United Kingdom 6 University of Birmingham, United Kingdom Background The complexity of bladder cancer (BC) diagnosis and staging results in delays to definitive treatment of muscle-invasive bladder cancer (MIBC) by radical cystectomy (RC). It remains unclear whether these delays influence outcomes. This review aimed to assess the impact of delays to RC on survival by systematic review and meta-analysis using currently available data. Methods Medline (PubMed) and Ovid Gateway (Embase and Ovid) were searched using protocol-driven search terms. The identified studies were then assessed according to inclusion and exclusion criteria. Meta-analyses were conducted based on type of delay (BC diagnosis to RC; transurethral resection (TURBT) to RC). Random-effects models were used whereby the presence of a delay (as defined by each study) was the exposure variable and overall survival was the outcome of interest, for which pooled HRs were calculated. Results Seventeen studies were eligible for inclusion, of which six were subsequently included in the meta-analysis. The studies varied greatly in how delays were defined. When studying total delay between BC diagnosis and RC, the meta-analysis revealed a pooled HR for overall death of 1.32 (95% CI: 1.13-1.54) when comparing those with a longer delay to those with a shorter delay (as defined by each study). For delay between TURBT and RC, we found a pooled HR of 1.17 (95% CI: 0.89-1.52) for death from all causes. The main limitation in the meta-analyses was study heterogeneity. Conclusions This review highlights the importance of treating those patients requiring RC without delay. Several factors impact delay, such as other medical conditions and scheduling, and these must be monitored by medical practitioners in order to minimise unnecessary delays to improve survival. Acknowledgements We would like to thank the Dianne and Graham Roberts Charitable Settlement and Fight Bladder Cancer for their support and input into this review. Keywords: Bladder cancer (BCa), radical cystectomy (RC), Survival, Delay, Systematic review Conference: Bladder Cancer Translational Research Meeting, London, United Kingdom, 29 Mar - 29 Mar, 2019. Presentation Type: Oral Topic: Optimisation of diagnostic pathways Citation: Russell B, Liedberg F, Khan MS, Nair R, Thurairaja R, Malde S, Kumar P and Bryan RT (2019). A systematic review and meta-analysis of delay to radical cystectomy and the effect on survival in bladder cancer patients. Front. Oncol. Conference Abstract: Bladder Cancer Translational Research Meeting. doi: 10.3389/conf.fonc.2019.01.00007 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Feb 2019; Published Online: 27 Sep 2019. * Correspondence: Miss. Beth Russell, King's College London, London, United Kingdom, beth.russell@kcl.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Beth Russell Fredrik Liedberg Muhammad S Khan Rajesh Nair Ramesh Thurairaja Sachin Malde Pardeep Kumar Richard T Bryan Google Beth Russell Fredrik Liedberg Muhammad S Khan Rajesh Nair Ramesh Thurairaja Sachin Malde Pardeep Kumar Richard T Bryan Google Scholar Beth Russell Fredrik Liedberg Muhammad S Khan Rajesh Nair Ramesh Thurairaja Sachin Malde Pardeep Kumar Richard T Bryan PubMed Beth Russell Fredrik Liedberg Muhammad S Khan Rajesh Nair Ramesh Thurairaja Sachin Malde Pardeep Kumar Richard T Bryan Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2976409404 title "A systematic review and meta-analysis of delay to radical cystectomy and the effect on survival in bladder cancer patients" @default.
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