Matches in SemOpenAlex for { <https://semopenalex.org/work/W2976414363> ?p ?o ?g. }
- W2976414363 endingPage "1317" @default.
- W2976414363 startingPage "1307" @default.
- W2976414363 abstract "Introduction: Calcitonin Gene-Related Peptide (CGRP) plays a crucial role in migraine pathophysiology. A novel specific treatment strategy for the prevention of migraine incorporates monoclonal antibodies (mAbs) against CGRP and its canonical receptor. Eptinezumab, fremanezumab and galcanezumab block CGRP mediated effects by binding to the peptide, while erenumab blocks the CGRP receptor.Areas covered: Following a brief overview of pharmacological characteristics, we will review phase III trials for the use of CGRP mAbs in the prevention of episodic and chronic migraine.Expert opinion: All four CGRP mAbs demonstrated an excellent safety, tolerability and efficacy profile in migraine patients. Across all trials mAbs showed superior efficacy for the reduction of monthly migraine days compared to placebo with a net benefit of 2.8 days. Neither cardiovascular nor immunological safety concerns have emerged from clinical trials. Fremanezumab, galcanezumab, and erenumab are approved in the USA and Europe. Based on trial data there is no reason why these mAbs should not become first-line therapies in future. For now, we advocate for the use of mAbs in migraine prevention for patients who failed a minimum of two standard oral treatments based on the novelty and costs of this approach. mAbs are also effective in patients with medication overuse and with comorbid depression or anxiety disorders. Taken together, mAbs are likely to usher in a new era in migraine prevention and provide significant value to patients." @default.
- W2976414363 created "2019-10-03" @default.
- W2976414363 creator A5031532333 @default.
- W2976414363 creator A5041465970 @default.
- W2976414363 creator A5051082265 @default.
- W2976414363 date "2019-10-03" @default.
- W2976414363 modified "2023-10-01" @default.
- W2976414363 title "Monoclonal antibodies for the prevention of migraine" @default.
- W2976414363 cites W1850605120 @default.
- W2976414363 cites W1891579824 @default.
- W2976414363 cites W1975671174 @default.
- W2976414363 cites W1980275741 @default.
- W2976414363 cites W1987630964 @default.
- W2976414363 cites W2025496772 @default.
- W2976414363 cites W2030751546 @default.
- W2976414363 cites W2031081542 @default.
- W2976414363 cites W2045777987 @default.
- W2976414363 cites W2048132386 @default.
- W2976414363 cites W2080336893 @default.
- W2976414363 cites W2085595272 @default.
- W2976414363 cites W2087994192 @default.
- W2976414363 cites W2097558849 @default.
- W2976414363 cites W2102917831 @default.
- W2976414363 cites W2117253164 @default.
- W2976414363 cites W2148445312 @default.
- W2976414363 cites W2162942726 @default.
- W2976414363 cites W2166206304 @default.
- W2976414363 cites W2283260670 @default.
- W2976414363 cites W2466122216 @default.
- W2976414363 cites W2527824850 @default.
- W2976414363 cites W2554491521 @default.
- W2976414363 cites W2591456584 @default.
- W2976414363 cites W2607327290 @default.
- W2976414363 cites W2608751463 @default.
- W2976414363 cites W2623864543 @default.
- W2976414363 cites W2736411845 @default.
- W2976414363 cites W2762361393 @default.
- W2976414363 cites W2766819558 @default.
- W2976414363 cites W2768357559 @default.
- W2976414363 cites W2770965214 @default.
- W2976414363 cites W2780526171 @default.
- W2976414363 cites W2792811290 @default.
- W2976414363 cites W2793946385 @default.
- W2976414363 cites W2800794691 @default.
- W2976414363 cites W2801341258 @default.
- W2976414363 cites W2803715733 @default.
- W2976414363 cites W2805822893 @default.
- W2976414363 cites W2805937849 @default.
- W2976414363 cites W2811448052 @default.
- W2976414363 cites W2880621648 @default.
- W2976414363 cites W2893863004 @default.
- W2976414363 cites W2895070640 @default.
- W2976414363 cites W2898072840 @default.
- W2976414363 cites W2899074290 @default.
- W2976414363 cites W2899821434 @default.
- W2976414363 cites W2900121305 @default.
- W2976414363 cites W2901687990 @default.
- W2976414363 cites W2920919248 @default.
- W2976414363 cites W2921665697 @default.
- W2976414363 cites W2922174162 @default.
- W2976414363 cites W2935951435 @default.
- W2976414363 cites W2939449854 @default.
- W2976414363 cites W2941010478 @default.
- W2976414363 cites W2944957936 @default.
- W2976414363 cites W2948901586 @default.
- W2976414363 cites W2954464607 @default.
- W2976414363 cites W4235888228 @default.
- W2976414363 cites W4238329561 @default.
- W2976414363 cites W4254363211 @default.
- W2976414363 cites W48934703 @default.
- W2976414363 doi "https://doi.org/10.1080/14712598.2019.1671350" @default.
- W2976414363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31550937" @default.
- W2976414363 hasPublicationYear "2019" @default.
- W2976414363 type Work @default.
- W2976414363 sameAs 2976414363 @default.
- W2976414363 citedByCount "47" @default.
- W2976414363 countsByYear W29764143632019 @default.
- W2976414363 countsByYear W29764143632020 @default.
- W2976414363 countsByYear W29764143632021 @default.
- W2976414363 countsByYear W29764143632022 @default.
- W2976414363 countsByYear W29764143632023 @default.
- W2976414363 crossrefType "journal-article" @default.
- W2976414363 hasAuthorship W2976414363A5031532333 @default.
- W2976414363 hasAuthorship W2976414363A5041465970 @default.
- W2976414363 hasAuthorship W2976414363A5051082265 @default.
- W2976414363 hasConcept C118303440 @default.
- W2976414363 hasConcept C126322002 @default.
- W2976414363 hasConcept C142724271 @default.
- W2976414363 hasConcept C159654299 @default.
- W2976414363 hasConcept C163170386 @default.
- W2976414363 hasConcept C163864487 @default.
- W2976414363 hasConcept C170493617 @default.
- W2976414363 hasConcept C197934379 @default.
- W2976414363 hasConcept C203014093 @default.
- W2976414363 hasConcept C204787440 @default.
- W2976414363 hasConcept C27081682 @default.
- W2976414363 hasConcept C2778375690 @default.
- W2976414363 hasConcept C2778541695 @default.