Matches in SemOpenAlex for { <https://semopenalex.org/work/W2976430235> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2976430235 endingPage "e17343" @default.
- W2976430235 startingPage "e17343" @default.
- W2976430235 abstract "Glecaprevir/pibrentasvir, a pan-genotypic and ribavirin-free direct acting antiviral agent regimen, has shown significant efficacy and very few serious complications. However, as the drug metabolizes in the liver, it is not recommended in patients with decompensated liver cirrhosis. Herein, we report the case of a patient with compensated liver cirrhosis who developed severe jaundice after glecaprevir/pibrentasvir medication.A 77-year-old man diagnosed with chronic hepatitis C-related compensated liver cirrhosis visited hospital due to severe jaundice after 12 weeks of glecaprevir/pibrentasvir medication.On the laboratory work-up, the total/direct bilirubin level was markedly elevated to 21.56/11.68 from 1.81 mg/dL; the alanine aminotransferase and aspartate aminotransferase levels were within the normal range. We checked the plasma drug concentration level of glecaprevir, and 18,500 ng/mL was detected, which was more than 15 times higher than the drug concentration level verified in normal healthy adults.Glecaprevir/pibrentasvir was abruptly stopped and after 6 days, the drug concentration level decreased to 35 ng/mL and the serum total/direct bilirubin decreased to 7.49/4.06 mg/dL.Three months after drug cessation, the serum total bilirubin level normalized to 1.21 mg/dL and HCV RNA was not detected.We report what is likely the first known case of severe jaundice after medication with glecaprevir/pibrentasvir in a patient with compensated liver cirrhosis. Clinicians should bear potential hyperbilirubinemia in mind when treating chronic hepatitis C with this regimen and should monitor the patient closely during follow-up laboratory exams, especially in elderly cirrhotic patients." @default.
- W2976430235 created "2019-10-03" @default.
- W2976430235 creator A5004314713 @default.
- W2976430235 creator A5016229974 @default.
- W2976430235 creator A5044479047 @default.
- W2976430235 creator A5047544881 @default.
- W2976430235 creator A5049189117 @default.
- W2976430235 creator A5054883403 @default.
- W2976430235 date "2019-09-01" @default.
- W2976430235 modified "2023-10-16" @default.
- W2976430235 title "A case report of glecaprevir/pibrentasvir-induced severe hyperbilirubinemia in a patient with compensated liver cirrhosis" @default.
- W2976430235 cites W1518370339 @default.
- W2976430235 cites W2049758833 @default.
- W2976430235 cites W2073816672 @default.
- W2976430235 cites W2086045517 @default.
- W2976430235 cites W2110962551 @default.
- W2976430235 cites W2129900097 @default.
- W2976430235 cites W2145933460 @default.
- W2976430235 cites W2185218296 @default.
- W2976430235 cites W2321640241 @default.
- W2976430235 cites W2419279616 @default.
- W2976430235 cites W2502200093 @default.
- W2976430235 cites W2741659988 @default.
- W2976430235 cites W2743670322 @default.
- W2976430235 cites W2746084941 @default.
- W2976430235 cites W2890778396 @default.
- W2976430235 cites W2896190011 @default.
- W2976430235 cites W4211138079 @default.
- W2976430235 cites W4293284804 @default.
- W2976430235 doi "https://doi.org/10.1097/md.0000000000017343" @default.
- W2976430235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6775421" @default.
- W2976430235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31574875" @default.
- W2976430235 hasPublicationYear "2019" @default.
- W2976430235 type Work @default.
- W2976430235 sameAs 2976430235 @default.
- W2976430235 citedByCount "8" @default.
- W2976430235 countsByYear W29764302352019 @default.
- W2976430235 countsByYear W29764302352021 @default.
- W2976430235 countsByYear W29764302352022 @default.
- W2976430235 countsByYear W29764302352023 @default.
- W2976430235 crossrefType "journal-article" @default.
- W2976430235 hasAuthorship W2976430235A5004314713 @default.
- W2976430235 hasAuthorship W2976430235A5016229974 @default.
- W2976430235 hasAuthorship W2976430235A5044479047 @default.
- W2976430235 hasAuthorship W2976430235A5047544881 @default.
- W2976430235 hasAuthorship W2976430235A5049189117 @default.
- W2976430235 hasAuthorship W2976430235A5054883403 @default.
- W2976430235 hasBestOaLocation W29764302351 @default.
- W2976430235 hasConcept C126322002 @default.
- W2976430235 hasConcept C2776029263 @default.
- W2976430235 hasConcept C2777214474 @default.
- W2976430235 hasConcept C2777513400 @default.
- W2976430235 hasConcept C2778456037 @default.
- W2976430235 hasConcept C2781413609 @default.
- W2976430235 hasConcept C71924100 @default.
- W2976430235 hasConcept C90924648 @default.
- W2976430235 hasConceptScore W2976430235C126322002 @default.
- W2976430235 hasConceptScore W2976430235C2776029263 @default.
- W2976430235 hasConceptScore W2976430235C2777214474 @default.
- W2976430235 hasConceptScore W2976430235C2777513400 @default.
- W2976430235 hasConceptScore W2976430235C2778456037 @default.
- W2976430235 hasConceptScore W2976430235C2781413609 @default.
- W2976430235 hasConceptScore W2976430235C71924100 @default.
- W2976430235 hasConceptScore W2976430235C90924648 @default.
- W2976430235 hasIssue "39" @default.
- W2976430235 hasLocation W29764302351 @default.
- W2976430235 hasLocation W29764302352 @default.
- W2976430235 hasLocation W29764302353 @default.
- W2976430235 hasLocation W29764302354 @default.
- W2976430235 hasLocation W29764302355 @default.
- W2976430235 hasOpenAccess W2976430235 @default.
- W2976430235 hasPrimaryLocation W29764302351 @default.
- W2976430235 hasRelatedWork W117349202 @default.
- W2976430235 hasRelatedWork W1550484024 @default.
- W2976430235 hasRelatedWork W1994748347 @default.
- W2976430235 hasRelatedWork W2089432473 @default.
- W2976430235 hasRelatedWork W2373473064 @default.
- W2976430235 hasRelatedWork W2376727204 @default.
- W2976430235 hasRelatedWork W2735540560 @default.
- W2976430235 hasRelatedWork W3000131867 @default.
- W2976430235 hasRelatedWork W3030708540 @default.
- W2976430235 hasRelatedWork W3032495226 @default.
- W2976430235 hasVolume "98" @default.
- W2976430235 isParatext "false" @default.
- W2976430235 isRetracted "false" @default.
- W2976430235 magId "2976430235" @default.
- W2976430235 workType "article" @default.