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• W2976448900 abstract "This thesis focuses on the effects of pharmacological strategies on thedevelopment of post-traumatic stress disorders (PTSD) in the context of interpersonalviolence. Part 1 reviews research literature examining the effects of pre-assaultsubstance consumption on PTSD symptoms amongst victims of sexual assault.Specifically, it investigates the effects of acute substance intoxication and chronic preassaultproblematic substance use on the severity and course of PTSD symptoms. Thereview highlights characterological self-blame and negative social reactions assignificant mediators of PTSD recovery in the context of pre-assault substanceconsumption.Part 2 comprises an empirical study investigating the effects of a single dose ofhydrocortisone on intrusive and declarative memories using the trauma film paradigmin a sample of female healthy participants. The findings highlight that hydrocortisoneorally administered within the memory consolidation period can effectively reduceintrusive memories. Compared to the placebo group, although declarative memory wasunaffected, the frequency and vividness of intrusive memories were significantlyreduced in the hydrocortisone group. This research project was jointly conducted withanother trainee from University College London (UCL) who investigated the effectsof propranolol on intrusive and declarative memories and used the same placebo group.Part 3, the critical appraisal, sets out a number of reflections on the process ofconducting the research project. The appraisal discusses personal assumptions for this project and how they were challenged and modified. The implications of the currentproject for future work are also considered." @default.
• W2976448900 created "2019-10-03" @default.
• W2976448900 creator A5083882484 @default.
• W2976448900 date "2018-11-12" @default.
• W2976448900 modified "2023-09-23" @default.
• W2976448900 title "Intrusive memories following a single dose of hydrocortisone : examining the effect of hydrocortisone on intrusive memories in healthy volunteers" @default.
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• W2976448900 hasPublicationYear "2018" @default.
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