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• W2976474865 endingPage "1552" @default.
• W2976474865 startingPage "1539" @default.
• W2976474865 abstract "Several HOX genes are aberrantly expressed in a wide range of cancers interfering with their development and resistance to treatment. This seems to be often caused by alterations in the methylation profiles of their promoters. The role of HOX gene products in cancer is highly ‘tissue specific’, relying ultimately on their ability to regulate oncogenes or tumor-suppressor genes, directly as transcriptional regulators or indirectly interfering with the levels of epigenetic regulators. Nowadays, different strategies have been tested the use of HOX genes as therapeutic targets for cancer diagnosis and treatment. Here, we trace the history of the research concerning the involvement of HOX genes in cancer, their connection with epigenetic regulation and their potential use as therapeutic targets." @default.
• W2976474865 created "2019-10-03" @default.
• W2976474865 creator A5048435470 @default.
• W2976474865 creator A5067994069 @default.
• W2976474865 date "2019-10-01" @default.
• W2976474865 modified "2023-09-30" @default.
• W2976474865 title "<i>HOX</i> genes as transcriptional and epigenetic regulators during tumorigenesis and their value as therapeutic targets" @default.
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