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- W2976516069 abstract "Endometrial polyps (EP) and redundant endometrium (RE) are often detected incidentally during routine transvaginal ultrasonography. Several studies on the expression of hormone receptors, oncogenes and antimitotic proteins have been conducted to elucidate the molecular mechanisms underlying EP, however, no studies have been reported on the biology of RE. We explored whether the expression of different endometrial markers could vary in patients with EP and RE and what is their role the etiology and pathogenesis of endometrial pathology. Pilot experimental study. We examined the expression of estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), insulin-like growth factor receptor 1 (IGFR-1), B-cell lymphoma 2 (bcl-2), Ki67, HOXA10 and thyroid receptor beta 1 (TR beta 1) in EP and RE. We obtained endometrial specimens from 16 patients aged 20-45 years, that presented to our center between September 2017 and May 2018 who were undergoing hysteroscopy for benign gynecologic pathology (EP, RE or submucosal fibroids). Fragments of the endometrial samples were processed for real-time RT-PCR analyses for the expression of the above-mentioned markers. The main outcome measure was tissue expression of these markers and comparison between EP and RE. We performed ANOVA for analysis among the 3 groups. Our results were summarized as median and quartiles (Q1, Q3) and we used SPSS v25 for Windows (SPSS, Chicago, IL); a p<0.05 defined significance. 8 patients had RE, 5 had EP, 1 RE plus EP, 2 had normal endometrium. Compared to EP, RE showed increased blc2 and Insulin-R but similar Ki67,IGF-R1 and HOXA10 expression. Compared to normal endometrium, RE showed increased bcl2, IGF-R1 and Insulin-R expression, while Ki67 was decreased and HOXA10 unchanged.Tabled 1VariableRedundant EndometriumMedian (Q1, Q3)PolypMedian (Q1, Q3)NormalMedian (Q1, Q3)p-value RE vs Polypp-value RE vs normalBCL2 (fg/ug RNA)0.263 (0.16, 0.32)0.082 (0.07, 0.09)0.068 (0.06, 0.07)0.02710.0184HOXA-10 (fg/ug RNA)35.05 (28.8, 43.7)35.33 (29.2, 48.9)40.56 (40.4, 41.7)nsnsKi67 (fg/ug RNA)1.45 (1.1, 2.3)2.51 (2.5, 7.3)5.72 (4.5, 5.9)ns0.0009IGF1-R (fg/ug RNA)6.25 (4.5, 7.0)4.42 (3.9, 5.8)2.61 (2.6, 2.8)ns0.0184Insulin-R (fg/ug RNA)53.33 (47.6, 58.6)39.69 (26.8, 44.4)15.6 (15.4, 16.0)0.03180.0002 Open table in a new tab RE showed biochemical characteristics similar to endometrial polyps, both stemming from environmental factors. Cell differentiation seemed more enhanced than replication. Similarly to EP, RE could be detrimental for embryo implantation, especially when extensive. This should be of consideration in women undergoing fertility treatments." @default.
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- W2976516069 date "2019-09-01" @default.
- W2976516069 modified "2023-10-18" @default.
- W2976516069 title "Redundant endometrium and endometrial polyps: is there a link?" @default.
- W2976516069 doi "https://doi.org/10.1016/j.fertnstert.2019.07.959" @default.
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