Matches in SemOpenAlex for { <https://semopenalex.org/work/W297652006> ?p ?o ?g. }
- W297652006 abstract "Introduction: Obesity, which is implicated in the development of the metabolic syndrome (MS) is reaching epidemic proportions worldwide. MS significantly increases the risk of developing cardiovascular disease, which includes coronary artery disease. The current absence of animal models of diet induced obesity and the MS makes the investigation of the cardiovascular consequences of MS virtually impossible. As a result the effects of the MS on cardiac function, morphology and susceptibility to ischaemia are not well understood. Aims: We set out to: 1) develop and characterize a rodent model of dietinduced obesity and the MS, 2) investigate the susceptibility of hearts from these animals to ischaemia/reperfusion induced injury and, 3) determine whether angiotensin II (Ang II) and endothelin-1 (ET-1) plays a role in cardiac remodelling and/or the severity of ischaemia and reperfusion injury in this model. Methods: Male Wistar rats were fed a standard rat chow diet or cafeteria diet (CD) for 16 weeks. After the feeding period rats were sacrificed and blood and myocardial tissue samples were collected to document biochemical changes in these animals. Hearts were perfused on the isolated working rat heart perfusion apparatus to assess myocardial mechanical function before and after ischaemia. In a separate series of experiments, hearts underwent coronary artery ligation to determine the incidence and duration of ventricular arrhythmias during ischaemia and reperfusion, using electrocardiography. To assess a" @default.
- W297652006 created "2016-06-24" @default.
- W297652006 creator A5011521546 @default.
- W297652006 date "2006-03-01" @default.
- W297652006 modified "2023-09-24" @default.
- W297652006 title "A PATHOLOGIC ROLE FOR ANGIOTENSIN II AND ENDOTHELIN-1 IN CARDIAC REMODELLING AND ISCHAEMIA AND REPERFUSION INJURY IN A RAT MODEL OF THE METABOLIC SYNDROME." @default.
- W297652006 cites W123433672 @default.
- W297652006 cites W126320974 @default.
- W297652006 cites W1460290523 @default.
- W297652006 cites W1507896895 @default.
- W297652006 cites W1516536009 @default.
- W297652006 cites W1565056239 @default.
- W297652006 cites W1572515149 @default.
- W297652006 cites W1588608604 @default.
- W297652006 cites W1672412245 @default.
- W297652006 cites W1700458277 @default.
- W297652006 cites W1787646291 @default.
- W297652006 cites W1880366974 @default.
- W297652006 cites W1889464010 @default.
- W297652006 cites W1908031530 @default.
- W297652006 cites W1927710737 @default.
- W297652006 cites W1938254948 @default.
- W297652006 cites W1939182803 @default.
- W297652006 cites W194457679 @default.
- W297652006 cites W1947575656 @default.
- W297652006 cites W1955102539 @default.
- W297652006 cites W1963739832 @default.
- W297652006 cites W1963941982 @default.
- W297652006 cites W1964891036 @default.
- W297652006 cites W1965121402 @default.
- W297652006 cites W1965570459 @default.
- W297652006 cites W1968304085 @default.
- W297652006 cites W1969397192 @default.
- W297652006 cites W1970680837 @default.
- W297652006 cites W1972362606 @default.
- W297652006 cites W1974552698 @default.
- W297652006 cites W1975827954 @default.
- W297652006 cites W1975851642 @default.
- W297652006 cites W1976905266 @default.
- W297652006 cites W1977699391 @default.
- W297652006 cites W1979381792 @default.
- W297652006 cites W1979576695 @default.
- W297652006 cites W1982087424 @default.
- W297652006 cites W1982869578 @default.
- W297652006 cites W1983692570 @default.
- W297652006 cites W1983967616 @default.
- W297652006 cites W1984658117 @default.
- W297652006 cites W1985067278 @default.
- W297652006 cites W1985281315 @default.
- W297652006 cites W1985754874 @default.
- W297652006 cites W1986226642 @default.
- W297652006 cites W1987249743 @default.
- W297652006 cites W1987746625 @default.
- W297652006 cites W1988031820 @default.
- W297652006 cites W1988354683 @default.
- W297652006 cites W1988962204 @default.
- W297652006 cites W1988995587 @default.
- W297652006 cites W1990391683 @default.
- W297652006 cites W1990805315 @default.
- W297652006 cites W1990941703 @default.
- W297652006 cites W1990950873 @default.
- W297652006 cites W1992642803 @default.
- W297652006 cites W1993007579 @default.
- W297652006 cites W1994422148 @default.
- W297652006 cites W1994636585 @default.
- W297652006 cites W1995641249 @default.
- W297652006 cites W1996704811 @default.
- W297652006 cites W1996841345 @default.
- W297652006 cites W1997768837 @default.
- W297652006 cites W1998696106 @default.
- W297652006 cites W1998900331 @default.
- W297652006 cites W1999716591 @default.
- W297652006 cites W2000206374 @default.
- W297652006 cites W2001161479 @default.
- W297652006 cites W2003329663 @default.
- W297652006 cites W2003674138 @default.
- W297652006 cites W2005019022 @default.
- W297652006 cites W2005108752 @default.
- W297652006 cites W2005135935 @default.
- W297652006 cites W2006990113 @default.
- W297652006 cites W2007697890 @default.
- W297652006 cites W2008024908 @default.
- W297652006 cites W2009169807 @default.
- W297652006 cites W2009661186 @default.
- W297652006 cites W2011348280 @default.
- W297652006 cites W2012590883 @default.
- W297652006 cites W2014087082 @default.
- W297652006 cites W2014220396 @default.
- W297652006 cites W2014578041 @default.
- W297652006 cites W2014901805 @default.
- W297652006 cites W2015358422 @default.
- W297652006 cites W2015543195 @default.
- W297652006 cites W2015591615 @default.
- W297652006 cites W2015836575 @default.
- W297652006 cites W2016615402 @default.
- W297652006 cites W2017054020 @default.
- W297652006 cites W2017221955 @default.
- W297652006 cites W2018943342 @default.
- W297652006 cites W2019522333 @default.
- W297652006 cites W2019620417 @default.