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- W2976585114 abstract "Programmed Death-1 (PD1) and PD-ligand (PDL)-1 have been reported to participate in the regulation of T cells homeostasis and peripheral tolerance and have an important role in fetomaternal tolerance during pregnancy. PD1 blockade leads to CD4+ T (especially Th1, Th17 cells) activation and proliferation, which in turn increases embryo resorption and reduces litter size in a mouse model. The goal of this study was to investigate the expression of PD1/PDL1 on CD4+ T cells of peripheral blood in women with recurrent pregnancy loss (RPL). A prospective cohort study. Forty-five women with RPL and 12 fertile women who had at least one or more live-born infants were enrolled in this pilot study. The expression of PD1/PDL1 on CD4+ T cells in the peripheral blood, including Th1, Th17, and Treg cells were analyzed by flow cytometry. The expression of PD1/PDL1 was tested using monoclonal antibodies (mAB) to CD279 (PD1) and CD274 (PDL1). The expression of Tregs was tested using mABs to CD45, CD3, CD4, CD25, and CD127. The expression of Th1 cells was tested using mAB to CD45, CD3, CD8, IFN-g or TNF-a. The expression of Th17 cells was tested using mAB to CD45, CD3, CD8, and IL-17. The proportions of PD1+ Th17 cells (CD4+IL17+CD279+ cells out of total CD4+T cells) were significantly lower in the RPL group than controls (P<0.05). However, there are no differences in PD1+ Th1 (CD4+TNF-a+ CD279+ and CD4+IFN-g+CD279+) and Treg (CD4+CD25+CD127+CD279+) cells between the RPL group and controls. The proportions of PDL1+ Th1 (CD4+IFN-gCD274+ and CD4+TNF-a+CD274+), Th17 (CD4+IL-17+CD274+), and Treg (CD4+CD25+CD127+CD274+) cells are not different between the RPL group and controls (P>0.05, respectively). In Th1 and Th17 cells, the proportions of PDL1+ (CD274+) cells were significantly higher than those of PD1+ (CD279+) cells in both the RPL group and controls (P<0.01 respectively). However, there were no differences in PDL1+ and PD1+ Treg cells in both groups. Decreased expression of PD1 on Th17 cells may lead to enhanced Th17 immunity and result in the imbalance between Treg and Th17 cells in women with RPL." @default.
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- W2976585114 date "2019-09-01" @default.
- W2976585114 modified "2023-10-18" @default.
- W2976585114 title "Decreased expression of PD1 in peripheral blood Th17 cells in women with unexplained recurrent pregnancy loss" @default.
- W2976585114 doi "https://doi.org/10.1016/j.fertnstert.2019.07.1162" @default.
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