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- W297663463 abstract "The role of conjugated linoleic acid (CLA) in regulating body weight and composition and obesity-linked type 2 diabetes appears to be complex. It is estimated that type 2 diabetes affects 7% of the population of the United States with the incidence of this disease increasing worldwide. In contrast to the conditions of normoglycemia or impaired glucose tolerance (IGT) associated with obesity, type 2 diabetes mellitus is distinguishable because it involves both insulin resistance and dysfunctional β-cells of the pancreas. Although CLA improves impaired glucose tolerance and insulin levels in diabetic rats, chronic feeding with CLA modestly increases fasting serum glucose and/or insulin in nondiabetic swine and mice. Further studies are required to understand the mechanisms and long-term implications of supplementation in humans for the prevention or treatment of type 2 diabetes. Although obesity is prevalent among individuals with IGT and type 2 diabetes, regional adipose tissue distribution may be a better correlative with insulin resistance." @default.
- W297663463 created "2016-06-24" @default.
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- W297663463 date "2020-03-05" @default.
- W297663463 modified "2023-09-24" @default.
- W297663463 title "Conjugated Linoleic Acids in Type 2 Diabetes Mellitus: Implications and Potential Mechanisms" @default.
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- W297663463 doi "https://doi.org/10.4324/9780429270703-19" @default.
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