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• W2976647519 endingPage "7946" @default.
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• W2976647519 abstract "Human trials combining external radiotherapy (RT) and metallic nanoparticles are currently underway in cancer patients. For internal RT, in which a radioisotope such as radioiodine is systemically administered into patients, there is also a need for enhancing treatment efficacy, decreasing radiation-induced side effects and overcoming radio-resistance. However, if strategies vectorising radioiodine through nanocarriers have been documented, sensitizing the neoplasm through the use of nanotherapeutics easily translatable to the clinic in combination with the standard systemic radioiodine treatment has not been assessed yet.The present study explored the potential of hybrid poly(methacrylic acid)-grafted gold nanoparticles to improve the performances of systemic 131I-mediated RT on cancer cells and in tumor-bearing mice. Such nanoparticles were chosen based on their ability previously described by our group to safely withstand irradiation doses while exhibiting good biocompatibility and enhanced cellular uptake.In vitro clonogenic assays performed on melanoma and colorectal cancer cells showed that poly(methacrylic acid)-grafted gold nanoparticles (PMAA-AuNPs) could efficiently lead to a marked tumor cell mortality when combined to a low activity of radioiodine, which alone appeared to be essentially ineffective on tumor cells. In vivo, tumor enrichment with PMAA-AuNPs significantly enhanced the killing potential of a systemic radioiodine treatment.This is the first report of a simple and reliable nanomedicine-based approach to reduce the dose of radioiodine required to reach curability. In addition, these results open up novel perspectives for using high-Z metallic NPs in additional molecular radiation therapy demonstrating heterogeneous dose distributions." @default.
• W2976647519 created "2019-10-03" @default.
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• W2976647519 date "2019-09-01" @default.
• W2976647519 modified "2023-10-15" @default.
• W2976647519 title "<p>Improving ¹³¹I Radioiodine Therapy By Hybrid Polymer-Grafted Gold Nanoparticles</p>" @default.
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• W2976647519 cites W1975657900 @default.
• W2976647519 cites W1984185945 @default.
• W2976647519 cites W1984801309 @default.
• W2976647519 cites W1989965771 @default.
• W2976647519 cites W1996830477 @default.
• W2976647519 cites W2003846651 @default.
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• W2976647519 cites W2038196783 @default.
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• W2976647519 cites W2130266193 @default.
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• W2976647519 cites W2132317474 @default.
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• W2976647519 doi "https://doi.org/10.2147/ijn.s211496" @default.
• W2976647519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6777639" @default.
• W2976647519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31686819" @default.
• W2976647519 hasPublicationYear "2019" @default.
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