FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2976706468> ?p ?o ?g. }

• W2976706468 endingPage "5661" @default.
• W2976706468 startingPage "5653" @default.
• W2976706468 abstract "Oxidative stress has been considered a major contributing factor to traumatic brain injury (TBI). Formononetin, a phytoestrogen that belongs to the flavonoid family, is extracted from plants and herbs such as the red clover. Growing evidence demonstrates that formononetin has antioxidant properties. Therefore, formononetin has potential use in treating oxidative stress injuries in TBI. In this study, the neuroprotective and antioxidant effects of formononetin against TBI, as well as the related probable mechanisms, were investigated. The TBI model was produced in male Wistar rats through Feeney's weight-drop model. At 1 day after TBI, the neurological function score and brain water content were assessed. TUNEL assay was used to determine neuronal apoptosis. The expression levels of miR-155, HO-1, and BACH1 were measured by RT-PCR and western blotting. Consequently, our findings showed that formononetin pretreatment for 5 days significantly improved the neurological scores, reduced brain edema and inhibited neuronal apoptosis in rats after TBI. MiR-155 was substantially decreased and BACH1 expression was significantly increased in the TBI model, while pretreatment with formononetin dramatically up-regulated the expression levels of miR-155 and HO-1 and down-regulated the protein expression of BACH1 in rats after TBI. In summary, formononetin has been shown to have neuroprotective effects, and the mechanisms of this effect may be associated with its inhibition of oxidative stress and activation of Nrf2-dependent antioxidant pathways in TBI." @default.
• W2976706468 created "2019-10-03" @default.
• W2976706468 creator A5021052031 @default.
• W2976706468 creator A5035113720 @default.
• W2976706468 creator A5045085415 @default.
• W2976706468 creator A5051155849 @default.
• W2976706468 creator A5058072464 @default.
• W2976706468 creator A5060229752 @default.
• W2976706468 creator A5066102428 @default.
• W2976706468 creator A5082830532 @default.
• W2976706468 date "2017-01-01" @default.
• W2976706468 modified "2023-10-11" @default.
• W2976706468 title "Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury in rats." @default.
• W2976706468 cites W1836802760 @default.
• W2976706468 cites W1973559709 @default.
• W2976706468 cites W1980686102 @default.
• W2976706468 cites W1994724667 @default.
• W2976706468 cites W2006989513 @default.
• W2976706468 cites W2009828929 @default.
• W2976706468 cites W2015392958 @default.
• W2976706468 cites W2047261980 @default.
• W2976706468 cites W2047913600 @default.
• W2976706468 cites W2068961255 @default.
• W2976706468 cites W2070497752 @default.
• W2976706468 cites W2071425128 @default.
• W2976706468 cites W2075886553 @default.
• W2976706468 cites W2080356582 @default.
• W2976706468 cites W2087251269 @default.
• W2976706468 cites W2125619731 @default.
• W2976706468 cites W2212210925 @default.
• W2976706468 cites W2219080167 @default.
• W2976706468 cites W2233210435 @default.
• W2976706468 cites W2235837253 @default.
• W2976706468 cites W2278150775 @default.
• W2976706468 cites W2279967268 @default.
• W2976706468 cites W2301476344 @default.
• W2976706468 cites W2322027732 @default.
• W2976706468 cites W2431176315 @default.
• W2976706468 cites W2566762230 @default.
• W2976706468 cites W2586825713 @default.
• W2976706468 cites W2588744471 @default.
• W2976706468 cites W2590302834 @default.
• W2976706468 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5752915" @default.
• W2976706468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29312517" @default.
• W2976706468 hasPublicationYear "2017" @default.
• W2976706468 type Work @default.
• W2976706468 sameAs 2976706468 @default.
• W2976706468 citedByCount "10" @default.
• W2976706468 countsByYear W29767064682018 @default.
• W2976706468 countsByYear W29767064682019 @default.
• W2976706468 countsByYear W29767064682022 @default.
• W2976706468 countsByYear W29767064682023 @default.
• W2976706468 crossrefType "journal-article" @default.
• W2976706468 hasAuthorship W2976706468A5021052031 @default.
• W2976706468 hasAuthorship W2976706468A5035113720 @default.
• W2976706468 hasAuthorship W2976706468A5045085415 @default.
• W2976706468 hasAuthorship W2976706468A5051155849 @default.
• W2976706468 hasAuthorship W2976706468A5058072464 @default.
• W2976706468 hasAuthorship W2976706468A5060229752 @default.
• W2976706468 hasAuthorship W2976706468A5066102428 @default.
• W2976706468 hasAuthorship W2976706468A5082830532 @default.
• W2976706468 hasConcept C118552586 @default.
• W2976706468 hasConcept C126322002 @default.
• W2976706468 hasConcept C134018914 @default.
• W2976706468 hasConcept C181199279 @default.
• W2976706468 hasConcept C185592680 @default.
• W2976706468 hasConcept C190283241 @default.
• W2976706468 hasConcept C196795494 @default.
• W2976706468 hasConcept C25498285 @default.
• W2976706468 hasConcept C2776151105 @default.
• W2976706468 hasConcept C2776217839 @default.
• W2976706468 hasConcept C2776578907 @default.
• W2976706468 hasConcept C2778004101 @default.
• W2976706468 hasConcept C2778298627 @default.
• W2976706468 hasConcept C2779219270 @default.
• W2976706468 hasConcept C2780955279 @default.
• W2976706468 hasConcept C2781017439 @default.
• W2976706468 hasConcept C55493867 @default.
• W2976706468 hasConcept C71924100 @default.
• W2976706468 hasConcept C98274493 @default.
• W2976706468 hasConceptScore W2976706468C118552586 @default.
• W2976706468 hasConceptScore W2976706468C126322002 @default.
• W2976706468 hasConceptScore W2976706468C134018914 @default.
• W2976706468 hasConceptScore W2976706468C181199279 @default.
• W2976706468 hasConceptScore W2976706468C185592680 @default.
• W2976706468 hasConceptScore W2976706468C190283241 @default.
• W2976706468 hasConceptScore W2976706468C196795494 @default.
• W2976706468 hasConceptScore W2976706468C25498285 @default.
• W2976706468 hasConceptScore W2976706468C2776151105 @default.
• W2976706468 hasConceptScore W2976706468C2776217839 @default.
• W2976706468 hasConceptScore W2976706468C2776578907 @default.
• W2976706468 hasConceptScore W2976706468C2778004101 @default.
• W2976706468 hasConceptScore W2976706468C2778298627 @default.
• W2976706468 hasConceptScore W2976706468C2779219270 @default.
• W2976706468 hasConceptScore W2976706468C2780955279 @default.
• W2976706468 hasConceptScore W2976706468C2781017439 @default.
• W2976706468 hasConceptScore W2976706468C55493867 @default.
• W2976706468 hasConceptScore W2976706468C71924100 @default.

• next