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- W2976813426 abstract "Several essential nutrients are required for nucleotide synthesis and DNA replication (folate, vitamin B12, magnesium, zinc, iron), maintenance of DNA methylation and chromosome stability (folate, vitamin B12), prevention of DNA oxidation (vitamin C, vitamin E, zinc, manganese, selenium), and DNA damage sensing and repair (niacin, zinc, iron, magnesium). Deficiency in these micronutrients increases DNA replication stress and genomic instability, exacerbates susceptibility to DNA damage caused by endogenous and environmental genotoxins, and, furthermore, disables normal control of gene expression by epigenetic mechanisms. Furthermore, it has become increasingly evident that severe protein calorie deficiency and excessive caloric intake leading to overweight/obesity are also associated with high augmentation of DNA damage, indicating the important role of appropriate macronutrient intake in genome integrity maintenance. Because DNA damage is the most fundamental pathology at the cellular level, it is essential to start defining dietary reference values based on DNA damage prevention and explore the feasibility of personalized nutrition for maintenance of genome integrity." @default.
- W2976813426 created "2019-10-03" @default.
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- W2976813426 date "2020-01-01" @default.
- W2976813426 modified "2023-09-23" @default.
- W2976813426 title "The Role of Nutrition in DNA Replication, DNA Damage Prevention and DNA Repair" @default.
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- W2976813426 doi "https://doi.org/10.1016/b978-0-12-804572-5.00004-5" @default.
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