Matches in SemOpenAlex for { <https://semopenalex.org/work/W2976938963> ?p ?o ?g. }
- W2976938963 endingPage "1472" @default.
- W2976938963 startingPage "1466" @default.
- W2976938963 abstract "Non-steroidal anti-inflammatory drugs (NSAIDs), including cyclooxygenase-2 (COX-2)-selective NSAIDs, are associated with adverse effects on bone tissue. These drugs are frequently the treatment of choice but are the least studied with respect to their repercussion on bone. The objective of this study was to determine the effects of celecoxib on cultured human osteoblasts. Human osteoblasts obtained by primary culture from bone samples were treated with celecoxib at doses of 0.75, 2, or 5μM for 24 h. The MTT technique was used to determine the effect on proliferation; flow cytometry to establish the effect on cell cycle, cell viability, and antigenic profile; and real-time polymerase chain reaction to measure the effect on gene expressions of the differentiation markers RUNX2, alkaline phosphatase (ALP), osteocalcin (OSC), and osterix (OSX). Therapeutic doses of celecoxib had no effect on osteoblast cell growth or antigen expression but had a negative impact on the gene expression of RUNX2 and OSC, although there was no significant change in the expression of ALP and OSX. Celecoxib at therapeutic doses has no apparent adverse effects on cultured human osteoblasts and only inhibits the expression of some differentiation markers. These characteristics may place this drug in a preferential position among NSAIDs used for analgesic and anti-inflammatory therapy during bone tissue repair." @default.
- W2976938963 created "2019-10-03" @default.
- W2976938963 creator A5005185363 @default.
- W2976938963 creator A5012263923 @default.
- W2976938963 creator A5016601720 @default.
- W2976938963 creator A5064093059 @default.
- W2976938963 creator A5075919613 @default.
- W2976938963 creator A5079868464 @default.
- W2976938963 creator A5084564981 @default.
- W2976938963 date "2019-01-01" @default.
- W2976938963 modified "2023-10-17" @default.
- W2976938963 title "Effects of Therapeutic Doses of Celecoxib on Several Physiological Parameters of Cultured Human Osteoblasts" @default.
- W2976938963 cites W1837763023 @default.
- W2976938963 cites W1892257529 @default.
- W2976938963 cites W1899691624 @default.
- W2976938963 cites W1964474592 @default.
- W2976938963 cites W1970477396 @default.
- W2976938963 cites W1973862091 @default.
- W2976938963 cites W1975810099 @default.
- W2976938963 cites W1980673876 @default.
- W2976938963 cites W1988170766 @default.
- W2976938963 cites W1998425265 @default.
- W2976938963 cites W2014363460 @default.
- W2976938963 cites W2033918073 @default.
- W2976938963 cites W2049085196 @default.
- W2976938963 cites W2052590294 @default.
- W2976938963 cites W2057870483 @default.
- W2976938963 cites W2090200021 @default.
- W2976938963 cites W2091947254 @default.
- W2976938963 cites W2093489016 @default.
- W2976938963 cites W2094932501 @default.
- W2976938963 cites W2100157099 @default.
- W2976938963 cites W2110032258 @default.
- W2976938963 cites W2111653126 @default.
- W2976938963 cites W2132356666 @default.
- W2976938963 cites W2147585077 @default.
- W2976938963 cites W2164708919 @default.
- W2976938963 cites W2168420558 @default.
- W2976938963 cites W2171324851 @default.
- W2976938963 cites W2327897293 @default.
- W2976938963 cites W2396245955 @default.
- W2976938963 cites W2558470394 @default.
- W2976938963 cites W2734471535 @default.
- W2976938963 cites W2746637066 @default.
- W2976938963 cites W2790926654 @default.
- W2976938963 cites W2802875128 @default.
- W2976938963 cites W2887227889 @default.
- W2976938963 cites W2898700653 @default.
- W2976938963 cites W2979763352 @default.
- W2976938963 doi "https://doi.org/10.7150/ijms.37857" @default.
- W2976938963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6818209" @default.
- W2976938963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31673238" @default.
- W2976938963 hasPublicationYear "2019" @default.
- W2976938963 type Work @default.
- W2976938963 sameAs 2976938963 @default.
- W2976938963 citedByCount "5" @default.
- W2976938963 countsByYear W29769389632020 @default.
- W2976938963 countsByYear W29769389632021 @default.
- W2976938963 countsByYear W29769389632022 @default.
- W2976938963 countsByYear W29769389632023 @default.
- W2976938963 crossrefType "journal-article" @default.
- W2976938963 hasAuthorship W2976938963A5005185363 @default.
- W2976938963 hasAuthorship W2976938963A5012263923 @default.
- W2976938963 hasAuthorship W2976938963A5016601720 @default.
- W2976938963 hasAuthorship W2976938963A5064093059 @default.
- W2976938963 hasAuthorship W2976938963A5075919613 @default.
- W2976938963 hasAuthorship W2976938963A5079868464 @default.
- W2976938963 hasAuthorship W2976938963A5084564981 @default.
- W2976938963 hasBestOaLocation W29769389631 @default.
- W2976938963 hasConcept C131075544 @default.
- W2976938963 hasConcept C1491633281 @default.
- W2976938963 hasConcept C160160445 @default.
- W2976938963 hasConcept C181199279 @default.
- W2976938963 hasConcept C185592680 @default.
- W2976938963 hasConcept C197934379 @default.
- W2976938963 hasConcept C202751555 @default.
- W2976938963 hasConcept C203014093 @default.
- W2976938963 hasConcept C2776363554 @default.
- W2976938963 hasConcept C2776467144 @default.
- W2976938963 hasConcept C2778260815 @default.
- W2976938963 hasConcept C2780783641 @default.
- W2976938963 hasConcept C502942594 @default.
- W2976938963 hasConcept C53227056 @default.
- W2976938963 hasConcept C553184892 @default.
- W2976938963 hasConcept C55493867 @default.
- W2976938963 hasConcept C62112901 @default.
- W2976938963 hasConcept C71924100 @default.
- W2976938963 hasConcept C98274493 @default.
- W2976938963 hasConceptScore W2976938963C131075544 @default.
- W2976938963 hasConceptScore W2976938963C1491633281 @default.
- W2976938963 hasConceptScore W2976938963C160160445 @default.
- W2976938963 hasConceptScore W2976938963C181199279 @default.
- W2976938963 hasConceptScore W2976938963C185592680 @default.
- W2976938963 hasConceptScore W2976938963C197934379 @default.
- W2976938963 hasConceptScore W2976938963C202751555 @default.
- W2976938963 hasConceptScore W2976938963C203014093 @default.
- W2976938963 hasConceptScore W2976938963C2776363554 @default.
- W2976938963 hasConceptScore W2976938963C2776467144 @default.