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- W2977046384 abstract "Abstract In this contribution, we characterized and synthesized two three-dimensional Cu(II) involving coordination polymers {[Cu(L1)](H2O)1}n (1·H2O) and {[Cu4Li(L2)2(μ3-OH)2(H2O)2](NO3)(H2O)(DMA)2}n (2, DMA = N,N-dimethylacetamide) along with their nanoparticles based on two pyridine-carboxylate ligands 5-(3′,5′-dicarboxylphenyl)nicotic acid (H3L2) as well as 3,3’-(pyridine-3,5-diyl)dibenzoic acid (H2L1) by utilizing solvothermal and sonochemical approaches. In addition, we reported the important role of nanoparticles 1–2 (denoted as 1 NPs and 2 NPs hereafter) on the treatment of human cancer in vivo and in vitro. Through Cell Counting Kit-8 (CCK8) assay, we determined the cell proliferation and cell viability of human oral squamous cell carcinoma cell line (HSC-4). This result cleared that nanoparticles 1 showed a higher anti-cancer activity on HSC-4 cancer cells compared with nanoparticle 2. The reactive oxygen species detection and the Annexin V-FITC/PI assay manifested that nanoparticle 1 could significantly enhance the apoptotic cells numbers via increasing the intracellular ROS accumulation. The in vivo treatment experiment also convinced that nanoparticle 1 reduced the tumor volume and then increase the weight of the mice." @default.
- W2977046384 created "2019-10-03" @default.
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- W2977046384 date "2020-01-01" @default.
- W2977046384 modified "2023-09-25" @default.
- W2977046384 title "RETRACTED: Two new Cu(II) coordination polymer nanostructures induce human oral squamous cell carcinoma apoptotic cell death in vitro and in vivo" @default.
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- W2977046384 doi "https://doi.org/10.1016/j.molstruc.2019.127142" @default.
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