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- W2977103681 abstract "To compare the outcomes of in vitro fertilization (IVF) and fresh embryo transfer (ET) using corifollitropin alfa in ultrashort GnRHa protocol and GnRH antagonist protocol. A retrospective observational analysis conducted in a university-affiliated infertility center. A total of 245 unselected patients undergoing IVF/fresh ET were enrolled between January 1 and December 31, 2017, including 135 treated with ultrashort GnRHa protocol and 110 treated with antagonist protocol. The primary outcomes were the duration of stimulation, dosage of additional gonadotropin for ovarian hyper stimulation, number of total injections and outpatient department (OPD) visits before ovulation triggering, ovarian response, and ovarian hyper stimulation syndrome (OHSS) rate. The secondary outcomes were rates of pregnancy, clinical pregnancy, and live birth. Patients treated with ultrashort GnRHa required lesser additional gonadotropin, fewer total injections, but had better ovarian responses, including more oocytes retrieved, more metaphase II oocytes, and more blastocysts than those treated with antagonist did. A premature LH surge occurred only in six patients treated with antagonist protocol. The OHSS rate was similar in the two groups. The rates of pregnancy (37.0% vs. 43.6%), clinical pregnancy (25.2% vs. 34.6%), and live birth (19.3% vs. 30.0%) did not differ significantly between the two groups.Tabled 1Ultrashort (n= 135)Antagonist (n= 110)P valueAge (years)37.04 ± 4.2836.56 ± 4.260.382BMI (kg/m2)21.69 ± 2.9522.24 ± 3.550.189AMH (ng/mL)2.58 ± 1.922.19 ± 2.210.142Stimulation days10.30 ± 1.528.88 ± 1.30<0.001∗∗∗No. of OPD visits before triggering2.04 ± 0.741.70 ± 0.64<0.001∗∗∗Additional FSH dosage (IU)637.78 ± 537.63802.95 ± 435.970.010∗No. of shots before triggering6.63 ± 1.888.62 ± 2.81<0.001∗∗∗LH (mIU/mL) before triggering1.12 ± 0.774.12 ± 6.81<0.001∗∗∗Premature LH surge rate0% (0)5.45% (6)0.006∗∗Max. E2 level (pg/mL)2333.87 ± 1441.061903.43 ± 1028.720.009∗∗No. of oocytes retrieved12.52 ± 8.129.40 ± 7.030.002∗∗MII rate (%)73.38 ± 20.4568.40 ± 15.010.642Fertilization rate (%)71.99 ± 19.6271.41 ± 20.690.821Blastocyst rate (%)33.81 ± 31.9621.05 ± 31.260.002∗∗Pregnancy rate (%)37.0443.640.294Clinical pregnancy rate (%)25.1934.550.110Live birth rate (%)19.2630.000.051Cumulative pregnancy rate (%)47.2451.380.527OHSS rate (%)1.4800.200 Open table in a new tab In unselected patients using corifollitropin alfa, the ultrashort GnRHa protocol needed low dose of additional gonadotropin and fewer injections but produced similar pregnancy outcomes than antagonist protocol did, suggesting that the ultrashort GnRHa protocol could be an alternative." @default.
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- W2977103681 date "2019-09-01" @default.
- W2977103681 modified "2023-10-18" @default.
- W2977103681 title "Corifollitropin alfa in the ultrashort gonadotropin-releasing hormone agonist (GnRHa) protocol: a novel patient-friendly alternative" @default.
- W2977103681 doi "https://doi.org/10.1016/j.fertnstert.2019.07.697" @default.
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