FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977122493> ?p ?o ?g. }

• W2977122493 abstract "Abstract Multifunctional proteins often perform their different functions when localized in different subcellular compartments. However, the mechanisms leading to their localization are largely unknown. Recently, 3’UTRs were found to regulate the cellular localization of newly synthesized proteins through the co-translational formation of 3’UTR-protein complexes. Here, we investigate the formation of 3’UTR-protein complexes involving multifunctional proteins by exploiting large-scale protein-protein and protein-RNA interaction networks. Focusing on 238 human ‘extreme multifunctional’ (EMF) proteins, we predicted 1411 3’UTR-protein complexes involving 128 EMF proteins and evaluated their role in regulating protein cellular localization and multifunctionality. Notably, we find that EMF proteins lacking localization addressing signals, yet present at both the nucleus and cell surface, often form 3’UTR-protein complexes. In addition, they provide EMF proteins with the diversity of interaction partners necessary to their multifunctionality. Archetypal moonlighting proteins are also predicted to form 3’UTR-protein complexes thereby reinforcing our findings. Finally, our results indicate that the formation of 3’UTR-protein complex may be a common phenomenon in human cells, affecting up to 20% of the proteins in the human interactome." @default.
• W2977122493 created "2019-10-03" @default.
• W2977122493 creator A5026984064 @default.
• W2977122493 creator A5060161630 @default.
• W2977122493 creator A5062540718 @default.
• W2977122493 creator A5088078230 @default.
• W2977122493 creator A5088248109 @default.
• W2977122493 date "2019-09-27" @default.
• W2977122493 modified "2023-09-27" @default.
• W2977122493 title "The role of 3’UTR-protein complexes in the regulation of protein multifunctionality and subcellular localization" @default.
• W2977122493 cites W1543610375 @default.
• W2977122493 cites W1969412365 @default.
• W2977122493 cites W1973582015 @default.
• W2977122493 cites W1981768599 @default.
• W2977122493 cites W1990580084 @default.
• W2977122493 cites W1997535872 @default.
• W2977122493 cites W2004351764 @default.
• W2977122493 cites W2012034410 @default.
• W2977122493 cites W2015094506 @default.
• W2977122493 cites W2030141485 @default.
• W2977122493 cites W2034863897 @default.
• W2977122493 cites W2063889859 @default.
• W2977122493 cites W2070268146 @default.
• W2977122493 cites W2079415210 @default.
• W2977122493 cites W2081375228 @default.
• W2977122493 cites W2082815320 @default.
• W2977122493 cites W2091817414 @default.
• W2977122493 cites W2096180769 @default.
• W2977122493 cites W2102619694 @default.
• W2977122493 cites W2118933593 @default.
• W2977122493 cites W2125810455 @default.
• W2977122493 cites W2126456089 @default.
• W2977122493 cites W2130725713 @default.
• W2977122493 cites W2156564520 @default.
• W2977122493 cites W2157459217 @default.
• W2977122493 cites W2163741321 @default.
• W2977122493 cites W2170747616 @default.
• W2977122493 cites W2178279848 @default.
• W2977122493 cites W2261598201 @default.
• W2977122493 cites W2323943568 @default.
• W2977122493 cites W2461965332 @default.
• W2977122493 cites W2604808360 @default.
• W2977122493 cites W2751247278 @default.
• W2977122493 cites W2761314921 @default.
• W2977122493 cites W2765258427 @default.
• W2977122493 cites W2767591791 @default.
• W2977122493 cites W2768885548 @default.
• W2977122493 cites W2785329615 @default.
• W2977122493 cites W2786460713 @default.
• W2977122493 cites W2789894805 @default.
• W2977122493 cites W2888316193 @default.
• W2977122493 cites W2888885392 @default.
• W2977122493 cites W2890344905 @default.
• W2977122493 cites W2897095947 @default.
• W2977122493 cites W2899234492 @default.
• W2977122493 cites W2901758876 @default.
• W2977122493 cites W2918086501 @default.
• W2977122493 cites W2921586121 @default.
• W2977122493 cites W2930785203 @default.
• W2977122493 cites W2969550528 @default.
• W2977122493 cites W4210702584 @default.
• W2977122493 cites W4240629327 @default.
• W2977122493 doi "https://doi.org/10.1101/784702" @default.
• W2977122493 hasPublicationYear "2019" @default.
• W2977122493 type Work @default.
• W2977122493 sameAs 2977122493 @default.
• W2977122493 citedByCount "1" @default.
• W2977122493 countsByYear W29771224932019 @default.
• W2977122493 crossrefType "posted-content" @default.
• W2977122493 hasAuthorship W2977122493A5026984064 @default.
• W2977122493 hasAuthorship W2977122493A5060161630 @default.
• W2977122493 hasAuthorship W2977122493A5062540718 @default.
• W2977122493 hasAuthorship W2977122493A5088078230 @default.
• W2977122493 hasAuthorship W2977122493A5088248109 @default.
• W2977122493 hasBestOaLocation W29771224931 @default.
• W2977122493 hasConcept C104317684 @default.
• W2977122493 hasConcept C105580179 @default.
• W2977122493 hasConcept C140051345 @default.
• W2977122493 hasConcept C185592680 @default.
• W2977122493 hasConcept C190062978 @default.
• W2977122493 hasConcept C22667442 @default.
• W2977122493 hasConcept C2776879804 @default.
• W2977122493 hasConcept C54355233 @default.
• W2977122493 hasConcept C70721500 @default.
• W2977122493 hasConcept C86803240 @default.
• W2977122493 hasConcept C89604277 @default.
• W2977122493 hasConcept C95444343 @default.
• W2977122493 hasConcept C9760119 @default.
• W2977122493 hasConceptScore W2977122493C104317684 @default.
• W2977122493 hasConceptScore W2977122493C105580179 @default.
• W2977122493 hasConceptScore W2977122493C140051345 @default.
• W2977122493 hasConceptScore W2977122493C185592680 @default.
• W2977122493 hasConceptScore W2977122493C190062978 @default.
• W2977122493 hasConceptScore W2977122493C22667442 @default.
• W2977122493 hasConceptScore W2977122493C2776879804 @default.
• W2977122493 hasConceptScore W2977122493C54355233 @default.
• W2977122493 hasConceptScore W2977122493C70721500 @default.
• W2977122493 hasConceptScore W2977122493C86803240 @default.
• W2977122493 hasConceptScore W2977122493C89604277 @default.
• W2977122493 hasConceptScore W2977122493C95444343 @default.

• next