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• W2977123826 abstract "Abstract Three-dimensional (3D) tissue-engineered models of the blood-brain barrier (BBB) recapitulate in vivo shear stress, cylindrical geometry, and cell-ECM interactions. Here we address four issues associated with BBB models: cell source, barrier function, cryopreservation, and matrix stiffness. We reproduce a directed differentiation of brain microvascular endothelial cells (dhBMECs) from two fluorescently labeled human induced pluripotent stem cell lines (hiPSCs) and demonstrate physiological permeability of Lucifer yellow over six days. Microvessels formed from cryopreserved dhBMECs show expression of BBB markers and maintain physiological barrier function comparable to non-cryopreserved cells. Microvessels displaying physiological barrier function are formed in collagen I hydrogels with stiffness matching that of human brain. The dilation response of microvessels was linear with increasing transmural pressure and was dependent on matrix stiffness. Together these results advance capabilities for tissue-engineered BBB models." @default.
• W2977123826 created "2019-10-03" @default.
• W2977123826 creator A5040999341 @default.
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• W2977123826 date "2019-09-27" @default.
• W2977123826 modified "2023-10-03" @default.
• W2977123826 title "Tissue-engineered blood-brain barrier models via directed differentiation of human induced pluripotent stem cells" @default.
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• W2977123826 doi "https://doi.org/10.1038/s41598-019-50193-1" @default.
• W2977123826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6764995" @default.
• W2977123826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31562392" @default.
• W2977123826 hasPublicationYear "2019" @default.
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