Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977144312> ?p ?o ?g. }
- W2977144312 abstract "Abstract A C9orf72 repeat expansion is the most common cause of both frontotemporal dementia and motor neuron disease. The expansion is translated to produce dipeptide repeat proteins (DPRs), which are toxic in vivo and in vitro. However, the mechanisms underlying DPR toxicity remain unclear. Mouse models which express DPRs at repeat lengths found in human disease are urgently required to investigate this. We aimed to generate transgenic mice expressing DPRs at repeat lengths of >1000 using alternative codon sequences, to reduce the repetitive nature of the insert. We found that although these inserts did integrate into the mouse genome, the alternative codon sequences did not protect from instability between generations. Our findings suggest that stable integration of long DPR sequences may not be possible. Administration of viral vectors after birth may be a more effective delivery method for long repeats." @default.
- W2977144312 created "2019-10-03" @default.
- W2977144312 creator A5008522814 @default.
- W2977144312 creator A5015982152 @default.
- W2977144312 creator A5016957771 @default.
- W2977144312 creator A5054635855 @default.
- W2977144312 date "2019-12-01" @default.
- W2977144312 modified "2023-09-27" @default.
- W2977144312 title "CRISPR/Cas9 does not facilitate stable expression of long C9orf72 dipeptides in mice" @default.
- W2977144312 cites W1533438796 @default.
- W2977144312 cites W1673222863 @default.
- W2977144312 cites W1837901569 @default.
- W2977144312 cites W1975315797 @default.
- W2977144312 cites W1984538960 @default.
- W2977144312 cites W2013397952 @default.
- W2977144312 cites W2038735530 @default.
- W2977144312 cites W2041964860 @default.
- W2977144312 cites W2044403261 @default.
- W2977144312 cites W2048181153 @default.
- W2977144312 cites W2054542675 @default.
- W2977144312 cites W2061487513 @default.
- W2977144312 cites W2073190029 @default.
- W2977144312 cites W2077463950 @default.
- W2977144312 cites W2083209381 @default.
- W2977144312 cites W2088483634 @default.
- W2977144312 cites W2095507785 @default.
- W2977144312 cites W2099232044 @default.
- W2977144312 cites W2123859383 @default.
- W2977144312 cites W2137039075 @default.
- W2977144312 cites W2150523249 @default.
- W2977144312 cites W2154945114 @default.
- W2977144312 cites W2163737705 @default.
- W2977144312 cites W2176639363 @default.
- W2977144312 cites W2187620259 @default.
- W2977144312 cites W2189443629 @default.
- W2977144312 cites W2286099491 @default.
- W2977144312 cites W2308742329 @default.
- W2977144312 cites W2338545563 @default.
- W2977144312 cites W2340195634 @default.
- W2977144312 cites W2534434026 @default.
- W2977144312 cites W2606009055 @default.
- W2977144312 cites W2787234767 @default.
- W2977144312 cites W2791520406 @default.
- W2977144312 cites W2809559846 @default.
- W2977144312 cites W2890455870 @default.
- W2977144312 cites W2906203237 @default.
- W2977144312 cites W2914644978 @default.
- W2977144312 cites W2946246317 @default.
- W2977144312 cites W2953775971 @default.
- W2977144312 doi "https://doi.org/10.1016/j.neurobiolaging.2019.09.010" @default.
- W2977144312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31676125" @default.
- W2977144312 hasPublicationYear "2019" @default.
- W2977144312 type Work @default.
- W2977144312 sameAs 2977144312 @default.
- W2977144312 citedByCount "3" @default.
- W2977144312 countsByYear W29771443122020 @default.
- W2977144312 countsByYear W29771443122022 @default.
- W2977144312 crossrefType "journal-article" @default.
- W2977144312 hasAuthorship W2977144312A5008522814 @default.
- W2977144312 hasAuthorship W2977144312A5015982152 @default.
- W2977144312 hasAuthorship W2977144312A5016957771 @default.
- W2977144312 hasAuthorship W2977144312A5054635855 @default.
- W2977144312 hasConcept C102230213 @default.
- W2977144312 hasConcept C104317684 @default.
- W2977144312 hasConcept C105580179 @default.
- W2977144312 hasConcept C127413603 @default.
- W2977144312 hasConcept C132455925 @default.
- W2977144312 hasConcept C141231307 @default.
- W2977144312 hasConcept C142724271 @default.
- W2977144312 hasConcept C144501496 @default.
- W2977144312 hasConcept C149364088 @default.
- W2977144312 hasConcept C166252455 @default.
- W2977144312 hasConcept C180754005 @default.
- W2977144312 hasConcept C20580545 @default.
- W2977144312 hasConcept C2777898937 @default.
- W2977144312 hasConcept C2778641062 @default.
- W2977144312 hasConcept C2779134260 @default.
- W2977144312 hasConcept C2779483572 @default.
- W2977144312 hasConcept C2780098074 @default.
- W2977144312 hasConcept C54355233 @default.
- W2977144312 hasConcept C70721500 @default.
- W2977144312 hasConcept C71924100 @default.
- W2977144312 hasConcept C78519656 @default.
- W2977144312 hasConcept C86803240 @default.
- W2977144312 hasConcept C98108389 @default.
- W2977144312 hasConceptScore W2977144312C102230213 @default.
- W2977144312 hasConceptScore W2977144312C104317684 @default.
- W2977144312 hasConceptScore W2977144312C105580179 @default.
- W2977144312 hasConceptScore W2977144312C127413603 @default.
- W2977144312 hasConceptScore W2977144312C132455925 @default.
- W2977144312 hasConceptScore W2977144312C141231307 @default.
- W2977144312 hasConceptScore W2977144312C142724271 @default.
- W2977144312 hasConceptScore W2977144312C144501496 @default.
- W2977144312 hasConceptScore W2977144312C149364088 @default.
- W2977144312 hasConceptScore W2977144312C166252455 @default.
- W2977144312 hasConceptScore W2977144312C180754005 @default.
- W2977144312 hasConceptScore W2977144312C20580545 @default.
- W2977144312 hasConceptScore W2977144312C2777898937 @default.
- W2977144312 hasConceptScore W2977144312C2778641062 @default.
- W2977144312 hasConceptScore W2977144312C2779134260 @default.