Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977184446> ?p ?o ?g. }
- W2977184446 endingPage "863" @default.
- W2977184446 startingPage "855" @default.
- W2977184446 abstract "Introduction: Chronic inflammatory diseases, including retinal diseases that are a major cause of vision loss, are associated with activation of the nucleotide-binding domain and leucine-rich repeat containing (NLR) protein-3 (NLRP3) inflammasome pathway. In chronic disease, the inflammasome becomes self-perpetuating, indicating a common pathway in such diseases irrespective of underlying etiology, and implying a shared solution is feasible. Connexin43 hemichannels correlate directly with NLRP3 inflammasome complex assembly (shown here in models of retinal disease). Connexin43 hemichannel-mediated ATP release is proposed to be the principal activator signal for inflammasome complex assembly in primary signal-sensitized cells. Connexin hemichannel block on its own is sufficient to inhibit the inflammasome pathway. Areas covered: We introduce chronic retinal disease, discuss available preclinical models and examine findings from these models regarding the targeting of connexin43 hemichannels and its effects on the inflammasome. Expert opinion: In over 25 animal disease models, connexin hemichannel regulation has shown therapeutic benefit, and one oral connexin hemichannel blocker, tonabersat (Xiflam), is Phase II ready with safety evidence in over 1000 patients. Regulating the connexin hemichannel provides a means to move quickly into clinical trials designed to ameliorate the progression of devastating chronic diseases of the eye, but also elsewhere in the body." @default.
- W2977184446 created "2019-10-03" @default.
- W2977184446 creator A5003040257 @default.
- W2977184446 creator A5020069021 @default.
- W2977184446 creator A5046539019 @default.
- W2977184446 creator A5050135304 @default.
- W2977184446 creator A5060064141 @default.
- W2977184446 date "2019-10-03" @default.
- W2977184446 modified "2023-10-16" @default.
- W2977184446 title "Targeting connexin hemichannels to control the inflammasome: the correlation between connexin43 and NLRP3 expression in chronic eye disease" @default.
- W2977184446 cites W1525399598 @default.
- W2977184446 cites W1526048391 @default.
- W2977184446 cites W1765830470 @default.
- W2977184446 cites W1981000098 @default.
- W2977184446 cites W1984671810 @default.
- W2977184446 cites W1984989438 @default.
- W2977184446 cites W1986662591 @default.
- W2977184446 cites W1989149160 @default.
- W2977184446 cites W2017079337 @default.
- W2977184446 cites W2032534351 @default.
- W2977184446 cites W2032552223 @default.
- W2977184446 cites W2037159369 @default.
- W2977184446 cites W2057299439 @default.
- W2977184446 cites W2069035576 @default.
- W2977184446 cites W2076258116 @default.
- W2977184446 cites W2085123274 @default.
- W2977184446 cites W2087917186 @default.
- W2977184446 cites W2092689006 @default.
- W2977184446 cites W2095238429 @default.
- W2977184446 cites W2106994851 @default.
- W2977184446 cites W2109127883 @default.
- W2977184446 cites W2120276758 @default.
- W2977184446 cites W2120666811 @default.
- W2977184446 cites W2120742009 @default.
- W2977184446 cites W2124017577 @default.
- W2977184446 cites W2137650873 @default.
- W2977184446 cites W2151388300 @default.
- W2977184446 cites W2153399820 @default.
- W2977184446 cites W2159269404 @default.
- W2977184446 cites W2160121103 @default.
- W2977184446 cites W2160226180 @default.
- W2977184446 cites W2170730572 @default.
- W2977184446 cites W2191954390 @default.
- W2977184446 cites W2199100869 @default.
- W2977184446 cites W2237292159 @default.
- W2977184446 cites W2461766912 @default.
- W2977184446 cites W2473514416 @default.
- W2977184446 cites W2481882640 @default.
- W2977184446 cites W2493585470 @default.
- W2977184446 cites W2538444480 @default.
- W2977184446 cites W2558979571 @default.
- W2977184446 cites W2620198502 @default.
- W2977184446 cites W2727006191 @default.
- W2977184446 cites W2742915095 @default.
- W2977184446 cites W2754310746 @default.
- W2977184446 cites W2766474851 @default.
- W2977184446 cites W2768605638 @default.
- W2977184446 cites W2782184507 @default.
- W2977184446 cites W2790638053 @default.
- W2977184446 cites W2794262191 @default.
- W2977184446 cites W2883053154 @default.
- W2977184446 cites W2883164760 @default.
- W2977184446 cites W2886924097 @default.
- W2977184446 cites W2888132367 @default.
- W2977184446 cites W2891189084 @default.
- W2977184446 cites W2905338245 @default.
- W2977184446 cites W2917624803 @default.
- W2977184446 cites W2941091513 @default.
- W2977184446 cites W2944565286 @default.
- W2977184446 cites W3188379877 @default.
- W2977184446 cites W829002595 @default.
- W2977184446 doi "https://doi.org/10.1080/14728222.2019.1673368" @default.
- W2977184446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31554417" @default.
- W2977184446 hasPublicationYear "2019" @default.
- W2977184446 type Work @default.
- W2977184446 sameAs 2977184446 @default.
- W2977184446 citedByCount "27" @default.
- W2977184446 countsByYear W29771844462020 @default.
- W2977184446 countsByYear W29771844462021 @default.
- W2977184446 countsByYear W29771844462022 @default.
- W2977184446 countsByYear W29771844462023 @default.
- W2977184446 crossrefType "journal-article" @default.
- W2977184446 hasAuthorship W2977184446A5003040257 @default.
- W2977184446 hasAuthorship W2977184446A5020069021 @default.
- W2977184446 hasAuthorship W2977184446A5046539019 @default.
- W2977184446 hasAuthorship W2977184446A5050135304 @default.
- W2977184446 hasAuthorship W2977184446A5060064141 @default.
- W2977184446 hasConcept C158157758 @default.
- W2977184446 hasConcept C169760540 @default.
- W2977184446 hasConcept C203014093 @default.
- W2977184446 hasConcept C2776914184 @default.
- W2977184446 hasConcept C2777209026 @default.
- W2977184446 hasConcept C2780228694 @default.
- W2977184446 hasConcept C2780827179 @default.
- W2977184446 hasConcept C55493867 @default.
- W2977184446 hasConcept C71924100 @default.
- W2977184446 hasConcept C79879829 @default.
- W2977184446 hasConcept C86803240 @default.