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• W2977188712 abstract "To study the effect of dehydroepiandrosterone (DHEA) supplementation in infertile women with expected normal ovarian response before intracytoplasmic sperm injection (ICSI) procedure. Randomized, double-blind, placebo-controlled study. All women attended the ART unit for first planned fresh embryo transfer ICSI cycles with expected normo-ovarian response were invited to participate in the study. Women were randomized in a 1:1 ratio to either group I (DHEA group) received two capsules of DHEA 25 mg (DHEA®, MRM Co., USA) or group II (placebo group) received two placebo capsules has the same shape, color and consistency starting eight weeks before the date of controlled ovarian hyperstimulation (COH) and continued throughout the whole stimulation period till the HCG triggering day. The primary outcome of the study was the mean antral follicle count (AFC) after eight weeks of treatment. The secondary outcomes included the duration of gonadotrophins stimulation in days, the dose of gonadotropins, the number and quality of retrieved oocytes, the endometrial thickness at hCG triggering day, the fertilization rate, implantation rate, clinical pregnancy rate (CBR) and the adverse effects of the medications. We randomly assigned 108 women into both groups (54 in each arm). No significant difference between both groups regarding the baseline demographic characteristics or serum AMH levels. The mean basal AFC after eight weeks of DHEA supplementation was (10.2±4.4 vs. 13.8±5.3, respectively, p<0.001), while no significant difference in the placebo group (10.4±4.5 vs. 10.7±4.6.respectively, p=0.24). No significant difference in the total gonadotropin doses in both groups (p=0.64). DHEA group had statistically significant higher total number of retrieved oocytes (15.3±6.20 vs. 12.9±5.70, p=0.001), and the percentage of good quality oocytes (70.6% vs. 52.3%, p=0.007). No difference between both groups regarding the fertilization rate (62.4% vs.51.7%, p=0.13), implantation rate (23.1% vs 20.4%, p=0.27), and the clinical pregnancy rate (37.0% vs. 35.2%. p=0.41). Regarding adverse effects, no patients reported major adverse effects during the study period. Only two patients from the DHEA group complained of hot flushes after four weeks of the supplement not interfering with their daily activities. The use of DHEA in anticipated normal responders eight weeks before ICSI could be valuable in increasing the AFC, the number and quality of the retrieved oocytes relative to placebo, however no improvement in the fertilization, implantation, and clinical pregnancy rates." @default.
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• W2977188712 date "2019-09-01" @default.
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• W2977188712 title "Effect of dehydroepiandrosterone (DHEA) supplementation on intracytoplasmic sperm injection outcome in infertile women with anticipated normo-ovarian response" @default.
• W2977188712 doi "https://doi.org/10.1016/j.fertnstert.2019.07.211" @default.
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