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- W2977252819 endingPage "4789" @default.
- W2977252819 startingPage "4777" @default.
- W2977252819 abstract "The Gram-negative bacterium Helicobacter pylori is the most common bacterial pathogen in humans, infecting 24-79% of the population at any time. Standard eradication protocols involve multi-target therapy including combinations of antibiotics, which has promoted the emergence of resistant strains. To address this challenge, we prepared antibiotic-free colloidal nanoparticles designed to interfere with the adhesion mechanisms of H. pylori and thus prevent both the onset and recurrence of infection. Our colloidal particles comprised a nanocapsule (NC) formulation based on an oil-core nanoemulsion co-stabilized with lysozyme and lecithin, coated with negatively charged low-molecular-weight (DexS40-NC) or high-molecular-weight (DexS500-NC) dextran sulfate, or positively charged chitosan (CSHMC+30-NC). The oil core of all NC formulations was also loaded with curcumin, a model lipophilic phytochemical substance with well-documented anti-inflammatory and anti-tumor activities. Our proof-of-principle experiments showed that the DexS40-NC formulation inhibited the adhesion of H. pylori to AGS stomach cells in a dose-dependent manner. DexS40-NC achieved more potent inhibition than DexS500-NC or uncoated control nanoemulsions, whereas the effect of CSHMC+30-NC was not clear-cut given the ability of this formulation to aggregate bacteria. DexS40-NC, unlike DexS500-NC, showed no cytotoxic effects against AGS, Caco-2, or MDCK cell lines. DexS40-NC is, therefore, a promising candidate for further development as an alternative or complementary therapy against H. pylori infections." @default.
- W2977252819 created "2019-10-10" @default.
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- W2977252819 creator A5087484634 @default.
- W2977252819 date "2019-10-03" @default.
- W2977252819 modified "2023-10-16" @default.
- W2977252819 title "Low-Molecular-Weight Dextran Sulfate Nanocapsules Inhibit the Adhesion of <i>Helicobacter pylori</i> to Gastric Cells" @default.
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- W2977252819 doi "https://doi.org/10.1021/acsabm.9b00523" @default.
- W2977252819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35021478" @default.
- W2977252819 hasPublicationYear "2019" @default.
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