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- W2977255649 abstract "Extracellular matrices (ECMs) derived from tissues and decellularized are widely used as biomaterials in tissue engineering applications because they encompass tissue-specific biological and physical cues. In this study, we utilized a solubilized decellularized tissue (dECM) obtained from skeletal muscle to fabricate a nanofibrous structure using the electrospinning technique. The dECM was chemically modified by methacrylate reaction (dECM-MA) to improve the structural stability before electrospinning. The electrospun dECM-MA nanofibers were combined with microscale fibrillated poly(lactide-co-glycolide) (PLGA) constructs fabricated by three-dimensional printing and fibrillation/leaching of poly(vinyl alcohol) to promote skeletal muscle cell orientation and maturation. Using the electrostatic force-assisted fiber-alignment method, a multiscale composite scaffold consisting of fibrillated PLGA and aligned dECM-MA nanofibers was fabricated. The multiscale dECM-MA/PLGA composite scaffold significantly promoted the cellular orientation and myotube formation of human muscle progenitor cells compared to control scaffolds. The results suggested the potential use of the multiscale dECM-MA/PLGA composite scaffold, which contains the biochemical and topographical cues, for bioengineering a skeletal muscle tissue construct." @default.
- W2977255649 created "2019-10-10" @default.
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- W2977255649 date "2019-10-04" @default.
- W2977255649 modified "2023-10-16" @default.
- W2977255649 title "Effect of Hierarchical Scaffold Consisting of Aligned dECM Nanofibers and Poly(lactide-<i>co</i>-glycolide) Struts on the Orientation and Maturation of Human Muscle Progenitor Cells" @default.
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- W2977255649 doi "https://doi.org/10.1021/acsami.9b12639" @default.
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