Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977263104> ?p ?o ?g. }
- W2977263104 endingPage "202" @default.
- W2977263104 startingPage "101" @default.
- W2977263104 abstract "Solute carrier (SLC) family transporters utilize an electrochemical potential difference or an ion gradient generated by primary active transporters for transporting their substrates across biological membranes. These transporters are categorized as facilitated transporters or secondary active transporters. More than 300 SLC transporters have been identified. SLC transporters related to drug transport mainly include SLC21 gene subfamily (organic anion-transporting polypeptides, OATPs), SLC22A gene subfamily (organic anion transporters, OATs; organic cation transporters, OCTs; or organic cation/carnitine transporters, OCTNs), SLC15A gene subfamily (peptide transporters, PEPTs), and SLC47A gene subfamily (multidrug and toxin extrusion, MATEs). In general, OCTs transport organic cations, OATPs transport large and fairly hydrophobic organic anions, OATs transport the smaller and more hydrophilic organic anions, and PEPTs are responsible for the uptake of di-/tripeptides and peptide-like drugs. MATEs are responsible for efflux of organic cations. These transporters also transport some endogenous substances, indicating that the dysfunction of SLCs not only disrupts homeostasis but also largely impacts on the disposition of their substrate drugs. This chapter will discuss these SLC family transporters, with an emphasis on tissue distribution, substrate specificity, transporter physiology, and clinical significance." @default.
- W2977263104 created "2019-10-10" @default.
- W2977263104 creator A5000665985 @default.
- W2977263104 date "2019-01-01" @default.
- W2977263104 modified "2023-10-16" @default.
- W2977263104 title "SLC Family Transporters" @default.
- W2977263104 cites W127809968 @default.
- W2977263104 cites W1482529442 @default.
- W2977263104 cites W1486376079 @default.
- W2977263104 cites W1486779292 @default.
- W2977263104 cites W1489183668 @default.
- W2977263104 cites W1508816133 @default.
- W2977263104 cites W1526492675 @default.
- W2977263104 cites W1550259003 @default.
- W2977263104 cites W1560686237 @default.
- W2977263104 cites W1565580371 @default.
- W2977263104 cites W1570757468 @default.
- W2977263104 cites W1576609740 @default.
- W2977263104 cites W1594154614 @default.
- W2977263104 cites W1598177340 @default.
- W2977263104 cites W1604547439 @default.
- W2977263104 cites W1647299452 @default.
- W2977263104 cites W170029080 @default.
- W2977263104 cites W1702196320 @default.
- W2977263104 cites W1728668287 @default.
- W2977263104 cites W1760656356 @default.
- W2977263104 cites W1783939843 @default.
- W2977263104 cites W1786595753 @default.
- W2977263104 cites W1801619426 @default.
- W2977263104 cites W1849840699 @default.
- W2977263104 cites W1868407335 @default.
- W2977263104 cites W1881803822 @default.
- W2977263104 cites W1893126297 @default.
- W2977263104 cites W1906327586 @default.
- W2977263104 cites W1943960200 @default.
- W2977263104 cites W1958953874 @default.
- W2977263104 cites W1963684723 @default.
- W2977263104 cites W1963760050 @default.
- W2977263104 cites W1964511612 @default.
- W2977263104 cites W1964530424 @default.
- W2977263104 cites W1966706151 @default.
- W2977263104 cites W1966774219 @default.
- W2977263104 cites W1966859174 @default.
- W2977263104 cites W1966866937 @default.
- W2977263104 cites W1967255647 @default.
- W2977263104 cites W1967401158 @default.
- W2977263104 cites W1968008268 @default.
- W2977263104 cites W1968731447 @default.
- W2977263104 cites W1969300589 @default.
- W2977263104 cites W1969416320 @default.
- W2977263104 cites W1969724420 @default.
- W2977263104 cites W1970369624 @default.
- W2977263104 cites W1971007225 @default.
- W2977263104 cites W1971435003 @default.
- W2977263104 cites W1971580188 @default.
- W2977263104 cites W1971901938 @default.
- W2977263104 cites W1972016245 @default.
- W2977263104 cites W1972101105 @default.
- W2977263104 cites W1973508181 @default.
- W2977263104 cites W1973810935 @default.
- W2977263104 cites W1974283364 @default.
- W2977263104 cites W1974574813 @default.
- W2977263104 cites W1975051553 @default.
- W2977263104 cites W1975322245 @default.
- W2977263104 cites W1975600234 @default.
- W2977263104 cites W1977469555 @default.
- W2977263104 cites W1977916977 @default.
- W2977263104 cites W1978556818 @default.
- W2977263104 cites W1979107541 @default.
- W2977263104 cites W1980916618 @default.
- W2977263104 cites W1980984502 @default.
- W2977263104 cites W1983184704 @default.
- W2977263104 cites W1983508148 @default.
- W2977263104 cites W1984565251 @default.
- W2977263104 cites W1984849493 @default.
- W2977263104 cites W1985875694 @default.
- W2977263104 cites W1986561666 @default.
- W2977263104 cites W1987131013 @default.
- W2977263104 cites W1987857738 @default.
- W2977263104 cites W1988347181 @default.
- W2977263104 cites W1988590162 @default.
- W2977263104 cites W1988642118 @default.
- W2977263104 cites W1988755578 @default.
- W2977263104 cites W1988914651 @default.
- W2977263104 cites W1989471847 @default.
- W2977263104 cites W1989664121 @default.
- W2977263104 cites W1989971260 @default.
- W2977263104 cites W1989987462 @default.
- W2977263104 cites W1990212853 @default.
- W2977263104 cites W1991103860 @default.
- W2977263104 cites W1991204820 @default.
- W2977263104 cites W1991896541 @default.
- W2977263104 cites W1991922944 @default.
- W2977263104 cites W1993263958 @default.
- W2977263104 cites W1994088225 @default.
- W2977263104 cites W1994255375 @default.
- W2977263104 cites W1994260622 @default.
- W2977263104 cites W1995408306 @default.