FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977263721> ?p ?o ?g. }

• W2977263721 abstract "Background Vitamin D deficiency during pregnancy increases the risk of pre‐eclampsia, gestational diabetes, preterm birth, and low birthweight. In a previous Cochrane Review we found that supplementing pregnant women with vitamin D alone compared to no vitamin D supplementation may reduce the risk of pre‐eclampsia, gestational diabetes, and low birthweight and may increase the risk of preterm births if it is combined with calcium. However the effects of different vitamin D regimens are not yet clear. Objectives To assess the effects and safety of different regimens of vitamin D supplementation alone or in combination with calcium or other vitamins, minerals or nutrients during pregnancy, specifically doses of 601 international units per day (IU/d) or more versus 600 IU/d or less; and 4000 IU/d or more versus 3999 IU/d or less. Search methods We searched the Cochrane Pregnancy and Childbirth’s Trials Register, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP) (12 July 2018), and the reference lists of retrieved studies. Selection criteria Randomised trials evaluating the effect of different vitamin D regimens (dose, frequency, duration, and time of commencement of supplementation during pregnancy), alone or in combination with other nutrients on pregnancy and neonatal health outcomes. We only included trials that compared 601 IU/d or more versus 600 IU/d or less and 4000 IU/d or more versus 3999 IU/d or less. We did not include in the analysis groups that received no vitamin D, as that comparison is assessed in another Cochrane Review. Data collection and analysis Two review authors independently: i) assessed the eligibility of studies against the inclusion criteria; ii) extracted data from included studies, and iii) assessed the risk of bias of the included studies. Our primary maternal outcomes were: pre‐eclampsia, gestational diabetes, and any adverse effects; our primary infant outcomes were preterm birth and low birthweight. Data were checked for accuracy. The certainty of the evidence was assessed using the GRADE approach. Main results In this review, we included data from 30 trials involving 7289 women. We excluded 11 trials, identified 16 ongoing/unpublished trials and two trials are awaiting classification. Overall risk of bias for the trials was mixed. Comparison 1. 601 IU/d or more versus 600 IU/d or less of vitamin D alone or with any other nutrient (19 trials; 5214 participants) Supplementation with 601 IU/d or more of vitamin D during pregnancy may make little or no difference to the risk of pre‐eclampsia (risk ratio (RR) 0.96, 95% confidence interval (CI) 0.65 to 1.42); 5 trials; 1553 participants,low‐certainty evidence), may reduce the risk of gestational diabetes (RR 0.54, 95% CI 0.34 to 0.86; 5 trials; 1846 participants; moderate‐certainty evidence), may make little or no difference to the risk of preterm birth (RR 1.25, 95% CI 0.92 to 1.69; 4 trials; 2294 participants; low‐certainty evidence); and may make little or no difference to the risk of low birthweight (RR 0.90, 95% CI 0.66 to 1.24; 4 trials; 1550 participants; very low‐certainty evidence) compared to women receiving 600 IU/d or less. Comparison 2. 4000 IU or more versus 3999 IU or less of vitamin D alone (15 trials; 4763 participants) Supplementation with 4000 IU/d or more of vitamin D during pregnancy may make little or no difference to the risk of: pre‐eclampsia (RR 0.87, 95% CI 0.62 to 1.22; 4 trials, 1903 participants, low‐certainty evidence); gestational diabetes (RR 0.89, 95% CI 0.56 to 1.42; 5 trials, 2276 participants; low‐certainty evidence); preterm birth (RR 0.85, 95% CI 0.64 to 1.12; 6 trials, 2948 participants, low‐certainty evidence); and low birthweight (RR 0.92, 95% CI 0.49 to 1.70; 2 trials; 1099 participants; low‐certainty evidence) compared to women receiving 3999 IU/d or less. Adverse events (such as hypercalcaemia, hypocalcaemia, hypercalciuria, and hypovitaminosis D) were reported differently in most trials; however, in general, there was little to no side effects reported or similar cases between groups. Authors' conclusions Supplementing pregnant women with more than the current vitamin D recommendation may reduce the risk of gestational diabetes; however, it may make little or no difference to the risk of pre‐eclampsia, preterm birth and low birthweight. Supplementing pregnant women with more than the current upper limit for vitamin D seems not to increase the risk of the outcomes evaluated. In general, the GRADE was considered low certainty for most of the primary outcomes due to serious risk of bias and imprecision of results. With respect to safety, it appears that vitamin D supplementation is a safe intervention during pregnancy, although the parameters used to determine this were either not reported or not consistent between trials. Future trials should be consistent in their reports of adverse events. There are 16 ongoing trials that when published, will increase the body of knowledge." @default.
• W2977263721 created "2019-10-10" @default.
• W2977263721 creator A5004981735 @default.
• W2977263721 creator A5017323942 @default.
• W2977263721 creator A5021497729 @default.
• W2977263721 creator A5030619199 @default.
• W2977263721 creator A5058475886 @default.
• W2977263721 creator A5071445106 @default.
• W2977263721 creator A5077498948 @default.
• W2977263721 creator A5078865306 @default.
• W2977263721 date "2019-10-03" @default.
• W2977263721 modified "2023-10-03" @default.
• W2977263721 title "Regimens of vitamin D supplementation for women during pregnancy" @default.
• W2977263721 cites W1519913046 @default.
• W2977263721 cites W1568134808 @default.
• W2977263721 cites W1575470777 @default.
• W2977263721 cites W1848443055 @default.
• W2977263721 cites W1911104948 @default.
• W2977263721 cites W1959947954 @default.
• W2977263721 cites W1960532056 @default.
• W2977263721 cites W1965964040 @default.
• W2977263721 cites W1967945945 @default.
• W2977263721 cites W1968205238 @default.
• W2977263721 cites W1978632146 @default.
• W2977263721 cites W1982121536 @default.
• W2977263721 cites W1983305453 @default.
• W2977263721 cites W1985225077 @default.
• W2977263721 cites W1988182228 @default.
• W2977263721 cites W1995585139 @default.
• W2977263721 cites W1999365413 @default.
• W2977263721 cites W2000422963 @default.
• W2977263721 cites W2005416498 @default.
• W2977263721 cites W2016190732 @default.
• W2977263721 cites W2023050477 @default.
• W2977263721 cites W2024330935 @default.
• W2977263721 cites W2027685025 @default.
• W2977263721 cites W2029119723 @default.
• W2977263721 cites W2034353352 @default.
• W2977263721 cites W2034653050 @default.
• W2977263721 cites W2035514750 @default.
• W2977263721 cites W2036058662 @default.
• W2977263721 cites W2036604633 @default.
• W2977263721 cites W2041314664 @default.
• W2977263721 cites W2051909250 @default.
• W2977263721 cites W2055999471 @default.
• W2977263721 cites W2064931540 @default.
• W2977263721 cites W2065679711 @default.
• W2977263721 cites W2067687117 @default.
• W2977263721 cites W2073314039 @default.
• W2977263721 cites W2078035241 @default.
• W2977263721 cites W2079433091 @default.
• W2977263721 cites W2085063771 @default.
• W2977263721 cites W2085133492 @default.
• W2977263721 cites W2085717886 @default.
• W2977263721 cites W2089668510 @default.
• W2977263721 cites W2097984614 @default.
• W2977263721 cites W2098224961 @default.
• W2977263721 cites W2098252119 @default.
• W2977263721 cites W2100473295 @default.
• W2977263721 cites W2101197395 @default.
• W2977263721 cites W2103544702 @default.
• W2977263721 cites W2106449126 @default.
• W2977263721 cites W2107808646 @default.
• W2977263721 cites W2110788986 @default.
• W2977263721 cites W2118540989 @default.
• W2977263721 cites W2124148711 @default.
• W2977263721 cites W2127560747 @default.
• W2977263721 cites W2132096646 @default.
• W2977263721 cites W2136083733 @default.
• W2977263721 cites W2138328097 @default.
• W2977263721 cites W2140060839 @default.
• W2977263721 cites W2141190891 @default.
• W2977263721 cites W2142763314 @default.
• W2977263721 cites W2144943649 @default.
• W2977263721 cites W2146660377 @default.
• W2977263721 cites W2147466732 @default.
• W2977263721 cites W2148351787 @default.
• W2977263721 cites W2154682059 @default.
• W2977263721 cites W2163507707 @default.
• W2977263721 cites W2173235304 @default.
• W2977263721 cites W2199767455 @default.
• W2977263721 cites W2233830625 @default.
• W2977263721 cites W2254958366 @default.
• W2977263721 cites W2263094600 @default.
• W2977263721 cites W2276518919 @default.
• W2977263721 cites W2298209477 @default.
• W2977263721 cites W2304475729 @default.
• W2977263721 cites W2318159813 @default.
• W2977263721 cites W2324748752 @default.
• W2977263721 cites W2325817714 @default.
• W2977263721 cites W2327249454 @default.
• W2977263721 cites W2330239303 @default.
• W2977263721 cites W2337534241 @default.
• W2977263721 cites W2341226486 @default.
• W2977263721 cites W2460879546 @default.
• W2977263721 cites W2467808580 @default.
• W2977263721 cites W2468618061 @default.
• W2977263721 cites W2469987520 @default.
• W2977263721 cites W2471446272 @default.
• W2977263721 cites W2475154392 @default.

• next