FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2977303612> ?p ?o ?g. }

• W2977303612 abstract "Abstract Background Low‐grade inflammation may be involved in the pathogenesis of functional dyspepsia (FD). We hypothesis that altered gastric permeability is involved in the onset and persistence of this disorder. Therefore, our aim was to evaluate gastric mucosal integrity and mast cell numbers in patients with FD. Methods We enrolled 58 patients with FD fulfilling the Rome III criteria ( H Pylori negative), 20 inflammatory control subjects ( H Pylori positive), and 20 healthy controls ( H Pylori negative). Probe‐based confocal endomicroscopy was performed using intravenous fluorescein to assess the paracellular fluorescein leakage and cell shedding. Mast cells were identified with quantitative immunohistochemistry on mucosal biopsies. Key Results Endomicroscopic score of paracellular permeability was significantly higher in H pylori‐ negative FD patients compared with healthy controls (1.45 ± 1.27 vs 3.69 ± 3.18, P = .006). However, FD patients and healthy controls did not show differences in cell shedding score (0.75 ± 0.79 vs 1.29 ± 1.14, P = .069). Mast cell numbers were significantly increased compared with healthy control samples (18.91 ± 5.47 vs 14.1 ± 3.88, P < .001). The magnitude of increase in permeability was positively correlated with mast cell numbers of FD patients ( r s = .6588, P < .0001), but not dyspepsia symptom scores. Conclusion and Inferences Impaired gastric barrier function is present in FD patients. This might provide a new pathophysiological mechanism and therapeutical target in FD." @default.
• W2977303612 created "2019-10-10" @default.
• W2977303612 creator A5001223001 @default.
• W2977303612 creator A5011016505 @default.
• W2977303612 creator A5023057525 @default.
• W2977303612 creator A5049078993 @default.
• W2977303612 creator A5064468525 @default.
• W2977303612 creator A5073177187 @default.
• W2977303612 date "2019-10-01" @default.
• W2977303612 modified "2023-10-16" @default.
• W2977303612 title "Impaired gastric mucosal integrity identified by confocal endomicroscopy in <i>Helicobacter pylori</i> ‐negative functional dyspepsia" @default.
• W2977303612 cites W1571278720 @default.
• W2977303612 cites W1964606763 @default.
• W2977303612 cites W1976947921 @default.
• W2977303612 cites W1983867214 @default.
• W2977303612 cites W1993145105 @default.
• W2977303612 cites W1993184653 @default.
• W2977303612 cites W1995215780 @default.
• W2977303612 cites W1998434532 @default.
• W2977303612 cites W2006194008 @default.
• W2977303612 cites W2015811249 @default.
• W2977303612 cites W2034282428 @default.
• W2977303612 cites W2046395686 @default.
• W2977303612 cites W2080924216 @default.
• W2977303612 cites W2086305769 @default.
• W2977303612 cites W2105637059 @default.
• W2977303612 cites W2112129392 @default.
• W2977303612 cites W2118191160 @default.
• W2977303612 cites W2138925273 @default.
• W2977303612 cites W2147141154 @default.
• W2977303612 cites W2149848289 @default.
• W2977303612 cites W2152336072 @default.
• W2977303612 cites W2155454428 @default.
• W2977303612 cites W2159024772 @default.
• W2977303612 cites W2160919674 @default.
• W2977303612 cites W2161238054 @default.
• W2977303612 cites W2166650939 @default.
• W2977303612 cites W2167062644 @default.
• W2977303612 cites W2411834688 @default.
• W2977303612 cites W2564573905 @default.
• W2977303612 cites W2891458669 @default.
• W2977303612 cites W4249534836 @default.
• W2977303612 doi "https://doi.org/10.1111/nmo.13719" @default.
• W2977303612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31574212" @default.
• W2977303612 hasPublicationYear "2019" @default.
• W2977303612 type Work @default.
• W2977303612 sameAs 2977303612 @default.
• W2977303612 citedByCount "8" @default.
• W2977303612 countsByYear W29773036122020 @default.
• W2977303612 countsByYear W29773036122022 @default.
• W2977303612 countsByYear W29773036122023 @default.
• W2977303612 crossrefType "journal-article" @default.
• W2977303612 hasAuthorship W2977303612A5001223001 @default.
• W2977303612 hasAuthorship W2977303612A5011016505 @default.
• W2977303612 hasAuthorship W2977303612A5023057525 @default.
• W2977303612 hasAuthorship W2977303612A5049078993 @default.
• W2977303612 hasAuthorship W2977303612A5064468525 @default.
• W2977303612 hasAuthorship W2977303612A5073177187 @default.
• W2977303612 hasConcept C10162356 @default.
• W2977303612 hasConcept C126322002 @default.
• W2977303612 hasConcept C142724271 @default.
• W2977303612 hasConcept C203014093 @default.
• W2977303612 hasConcept C2776409635 @default.
• W2977303612 hasConcept C2776914184 @default.
• W2977303612 hasConcept C2779726688 @default.
• W2977303612 hasConcept C2780942790 @default.
• W2977303612 hasConcept C2781071285 @default.
• W2977303612 hasConcept C71924100 @default.
• W2977303612 hasConcept C90924648 @default.
• W2977303612 hasConceptScore W2977303612C10162356 @default.
• W2977303612 hasConceptScore W2977303612C126322002 @default.
• W2977303612 hasConceptScore W2977303612C142724271 @default.
• W2977303612 hasConceptScore W2977303612C203014093 @default.
• W2977303612 hasConceptScore W2977303612C2776409635 @default.
• W2977303612 hasConceptScore W2977303612C2776914184 @default.
• W2977303612 hasConceptScore W2977303612C2779726688 @default.
• W2977303612 hasConceptScore W2977303612C2780942790 @default.
• W2977303612 hasConceptScore W2977303612C2781071285 @default.
• W2977303612 hasConceptScore W2977303612C71924100 @default.
• W2977303612 hasConceptScore W2977303612C90924648 @default.
• W2977303612 hasFunder F4320313681 @default.
• W2977303612 hasFunder F4320321001 @default.
• W2977303612 hasFunder F4320333255 @default.
• W2977303612 hasIssue "1" @default.
• W2977303612 hasLocation W29773036121 @default.
• W2977303612 hasOpenAccess W2977303612 @default.
• W2977303612 hasPrimaryLocation W29773036121 @default.
• W2977303612 hasRelatedWork W1987712008 @default.
• W2977303612 hasRelatedWork W206400756 @default.
• W2977303612 hasRelatedWork W2069137464 @default.
• W2977303612 hasRelatedWork W2151605680 @default.
• W2977303612 hasRelatedWork W2336604641 @default.
• W2977303612 hasRelatedWork W2408733078 @default.
• W2977303612 hasRelatedWork W2417694848 @default.
• W2977303612 hasRelatedWork W2564435762 @default.
• W2977303612 hasRelatedWork W3153220433 @default.
• W2977303612 hasRelatedWork W54128201 @default.
• W2977303612 hasVolume "32" @default.
• W2977303612 isParatext "false" @default.
• W2977303612 isRetracted "false" @default.

• next