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- W2977303957 endingPage "580" @default.
- W2977303957 startingPage "549" @default.
- W2977303957 abstract "ATP-binding cassette (ABC) transporters are involved in active pumping of many diverse substrates through the cellular membrane. The transport mediated by these proteins modulates the pharmacokinetics of many drugs and xenobiotics. These transporters are involved in the pathogenesis of several human diseases. The overexpression of certain transporters by cancer cells has been identified as a key factor in the development of resistance to chemotherapeutic agents. In this chapter, the localization of ABC transporters in the human body, their physiological roles, and their roles in the development of multidrug resistance (MDR) are reviewed. Specifically, P-glycoprotein (P-GP), multidrug resistance-associated proteins (MRPs), and breast cancer resistance protein (BCRP/ABCG2) are described in more detail. The potential of ABC transporters as therapeutic targets to overcome MDR and strategies for this purpose are discussed as well as various explanations for the lack of efficacy of ABC drug transporter inhibitors to increase the efficiency of chemotherapy." @default.
- W2977303957 created "2019-10-10" @default.
- W2977303957 creator A5003110066 @default.
- W2977303957 creator A5004261103 @default.
- W2977303957 creator A5050548288 @default.
- W2977303957 creator A5050699960 @default.
- W2977303957 creator A5081938413 @default.
- W2977303957 date "2019-01-01" @default.
- W2977303957 modified "2023-10-14" @default.
- W2977303957 title "ABC Transporter-Mediated Multidrug-Resistant Cancer" @default.
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