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- W2977308886 abstract "Purpose: Although the major burden of heartburn and acid reflux in gastroesophageal reflux disease (GERD) occurs during the awake period, studies of antisecretory drugs used to predict efficacy for the treatment of GERD typically report gastric pH data for 24 hours. This analysis explores the effects of esomeprazole 20 mg on intragastric pH during the 14-hour awake “daytime” period using data from three previously published studies.1-3 Methods: In one double-blind1 and two open-label2,3 randomized studies, intragastric pH was monitored for 24 hours on day five of treatment with esomeprazole, both in patients with GERD and healthy volunteers. Post-hoc analyses to determine acid control over the 14-hour daytime period in patients treated with esomeprazole 20 mg were conducted. The mean percentage of time with pH >4 and the proportion of subjects with pH >4 for ≥8 hours during treatment with esomeprazole 20 mg were calculated in each study. Results: The results are presented in the Table.Table: Table. Intragastric acid control during the 14-Hour daytime period with esomeprazole 20 mgConclusion: Esomeprazole 20 mg provides intragastric pH control throughout at least half of the 14-hour awake period of the day, despite the challenge of food-stimulated acid secretion. Additional analyses of the effects of esomeprazole 20 mg and other proton pump inhibitors on daytime control of gastric pH are warranted because acid control during the awake period is most relevant for the treatment of frequent heartburn." @default.
- W2977308886 created "2019-10-10" @default.
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- W2977308886 date "2013-10-01" @default.
- W2977308886 modified "2023-09-26" @default.
- W2977308886 title "New Analyses of Daytime Acid Control with Esomeprazole 20 mg" @default.
- W2977308886 doi "https://doi.org/10.14309/00000434-201310001-00126" @default.
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