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- W2977320171 abstract "V poslednĂ dobÄ se dĂky screeningovĂŠmu vyĹĄetĹenĂ plazmatickĂŠho vĂĄpnĂku setkĂĄvĂĄme stĂĄle ÄastÄji s tzv. asymptomatickou formou primĂĄrnĂ hyperparatyreĂłzy (PHPT). Tato forma se v ekonomicky vyspÄlĂ˝ch zemĂch podĂlĂ vĂce neĹž z 80 % na celkovĂŠm vĂ˝skytu hyperparatyreĂłzy. A i kdyĹž tito pacienti nemajĂ vĂ˝raznĂŠ klinickĂŠ obtĂĹže, je nutno cĂlenÄ pĂĄtrat po orgĂĄnovĂŠm postiĹženĂ. I mĂrnĂŠ formy PHPT jsou totiĹž kromÄ Ăşbytku kostnĂho minerĂĄlu spojeny se zvýťenĂ˝m rizikem obratlovĂ˝ch zlomenin. Rozsah vyĹĄetĹenĂ i doporuÄenĂ, kterĂŠ pacienty odeslat k paratyroidektomii, vychĂĄzĂ z doporuÄenĂ expertnĂho panelu z roku 2014. Vedle hyperkalcemickĂŠ formy existuje tzv. normokalcemickĂĄ varianta PHPT, kterĂĄ by mohla bĂ˝t v populaci jeĹĄtÄ ÄastÄjĹĄĂ podobou onemocnÄnĂ. Vedle kalcemie by tak souÄĂĄstĂ screeningu mÄl bĂ˝t ideĂĄlnÄ i parathormon. NezvýťenĂŠ, ale ve vztahu k hyperkalcemii neadekvĂĄtnÄ vysokĂŠ hodnoty parathormonu charakterizujĂ tzv. normohormonĂĄlnĂ PHPT. PĹi podezĹenĂ na hereditĂĄrnĂ formu PHPT je indikovĂĄno genetickĂŠ vyĹĄetĹenĂ. I kdyĹž se v poslednĂch letech definujĂ novĂŠ klinickĂŠ formy onemocnÄnĂ, pĹedstavuje paratyroidektomie stĂĄle jedinĂŠ kurativnĂ ĹeĹĄenĂ, kterĂŠ je spojeno zejmĂŠna s vĂ˝znamnĂ˝m osteoprotektivnĂm efektem." @default.
- W2977320171 created "2019-10-10" @default.
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- W2977320171 date "2017-09-01" @default.
- W2977320171 modified "2023-10-18" @default.
- W2977320171 title "Primary hyperparathyroidism - new clinical forms of the disease" @default.
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- W2977320171 doi "https://doi.org/10.36290/vnl.2017.120" @default.
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