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• W2977322013 abstract "Barrigenol-like triterpenoids (BATs) showed promising anti-tumor, anti-inflammatory and anti-Alzheimer's activities, while, the inhibitory strength was usually affected by their states with aglycones or glycosides. In order to find more BATs as new anti-tumor agents with much more efficiency, the chemical and pharmaceutical studies were carried out on the acid hydrolysate product (AHP) of Semen Aesculi crude extract. Thirteen BATs, including three new aglycones (1-3), two new glycosides (4, 5) and eight known glycosides (6-13) were obtained. Compound 1, as the main product in AHP, with a tigloyl unit linked at the C-16 position was an unusual aglycone. All compounds exhibited various degrees of inhibitory activity against human breast cell line (MCF-7) and cervical cancer cell line (HeLa) growth, moreover, new aglycones 1 and 2, and the known glycoside 6 (escin Ia) and 9 were found to exhibit potent inhibitory activity which were similar to the positive control (doxorubicin hydrochloride). Compound 1, named 16-tigloyl-O-protoaescigenin, could suppress tumor progression and decreased lung metastasis focuses in mice, and no pathological change was observed at the end of the treatment course. Besides that, the hemolysis experiment between 1 and 6 revealed that the hemolysis toxicity of 1 was much less than that of 6. According to these results, 16-tigloyl-O-protoaescigenin, with the powerful anti-tumor activity and cancer cell apoptosis induction, might be considered as a new promising anti-tumor agent." @default.
• W2977322013 created "2019-10-10" @default.
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• W2977322013 date "2019-01-01" @default.
• W2977322013 modified "2023-09-27" @default.
• W2977322013 title "16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity <i>in vivo</i> and <i>in vitro</i>" @default.
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• W2977322013 doi "https://doi.org/10.1039/c9ra06015d" @default.
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• W2977322013 hasPublicationYear "2019" @default.
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