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- W2977363633 abstract "Introduction: Since Gulf War I, the number of patients diagnosed with inflammatory bowel disease (IBD) in our center has increased more than 4-fold. The increased risk of colorectal cancer (CRC), which is directly proportional to the duration and extent of disease, has led to increased frequency of colonoscopy (C-Scope) surveillance with multiple biopsy specimens taken from each segment. Yet, there are no controlled trials to demonstrate that frequent surveillance reduces mortality. The primary aim of this study is to determine the incidence of CRC in two groups of VA patients: (1) those undergoing long-term surveillance for IBD and (2) those undergoing long-term surveillance for colon adenomas removed at screening C-Scope. Methods: The records of all patients diagnosed with IBD whose first C-Scope completed at our institution was between January 1996 and December 2010 were obtained. These were compared with a control group of age-matched patients undergoing surveillance for benign adenoma(s) removed during screening C-Scope in the same period. CRC patients diagnosed within one year of first C-Scope (prevalent) were excluded. Results: A total of 548 IBD patients and 1103 controls were followed for a mean of 8.6 years (1-14.9). The overall 8.6-year incidence of CRC was 0.55% and 0.54% in the IBD and control groups respectively (O.R.=1.01). CRC developed in 6 control and 3 IBD patients, and none of these patients died from CRC. In the 3 IBD patients, the CRC appeared 34, 37, and 39 years after onset of disease, but 17, 6, and 15 years after our first C-Scope. More than 1610 C-Scopes, and more than 19,320 biopsies were performed to detect the 3 IBD CRCs. Conclusion: In patients undergoing surveillance, the incidence of CRC in IBD was nearly identical to the incidence of CRC with benign adenomas (1 in 200 over 8.6 years). The need for such frequent surveillance C-Scopes in patients with IBD needs to be re-assessed.Figure 1" @default.
- W2977363633 created "2019-10-10" @default.
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- W2977363633 date "2015-10-01" @default.
- W2977363633 modified "2023-09-27" @default.
- W2977363633 title "Surveillance Colonoscopy to Detect Colorectal Cancer in Patients With Inflammatory Bowel Disease: Is It Too Frequent?" @default.
- W2977363633 doi "https://doi.org/10.14309/00000434-201510001-01977" @default.
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